A5013186172- Optical Imaging and Spectroscopy Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Photoacoustic and Ultrasonic Imaging
- Non-Invasive Vital Sign Monitoring
- Thermoregulation and physiological responses
- Water Quality Monitoring and Analysis
- Climate Change and Health Impacts
- Infrared Thermography in Medicine
- VLSI and Analog Circuit Testing
- VLSI and FPGA Design Techniques
- Embedded Systems Design Techniques
- Spectroscopy and Chemometric Analyses
- Calibration and Measurement Techniques
Athinoula A. Martinos Center for Biomedical Imaging
2024
Massachusetts Institute of Technology
2023-2024
Boston University
2023-2024
Harvard University
2024
Massachusetts General Hospital
2024
MIT Lincoln Laboratory
2023
SignificanceThe non-invasive measurement of cerebral blood flow based on diffuse optical techniques has seen increased interest as a research tool for perfusion monitoring in critical care and functional brain imaging. Diffuse correlation spectroscopy (DCS) speckle contrast (SCOS) are two such that measure complementary aspects the fluctuating intensity signal, with DCS quantifying temporal fluctuations signal SCOS spatial blurring pattern. With increasing use these techniques, thorough...
Cerebral blood flow (CBF) dysregulation is correlated with pathologies including ischemic stroke and Alzheimer's disease. Portable real-time CBF monitoring, spatial specificity, would aid neuroscience research clinical decision-making. Recently, speckle contrast optical spectroscopy (SCOS) enabled non-invasive human measurement, demonstrating a higher signal-to-noise ratio (SNR) compared to traditional methods. This work advances the SCOS state-of-the-art by developing high-density,...
Abstract Speckle contrast optical spectroscopy (SCOS) is an emerging camera-based technique that can measure human cerebral blood flow (CBF) with high signal-to-noise ratio (SNR). At low photon flux levels typically encountered in CBF measurements, camera noise and nonidealities could significantly impact SCOS measurement SNR accuracy. Thus, a guide for characterizing, selecting, optimizing measurements crucial the development of next-generation devices monitoring brain function. Here, we...
Functional near-infrared spectroscopy (fNIRS) and diffuse correlation (DCS) have shown promise as non-invasive optical methods for cerebral functional imaging. DCS approaches currently limited sensitivity in adults. fNIRS is also limited, particularly high-detector-density applications. Sensitivity can be improved using temporal discrimination (TD), where the laser excitation of short (~400ps) duration detector rejects early photons that not penetrated into brain while maintain high to those...
Speckle contrast optical spectroscopy (SCOS) is an emerging camera-based technique that can measure human cerebral blood flow (CBF) noninvasively with high signal-to-noise ratio (SNR). A noise correction procedure has previously been developed to improve SCOS measurement accuracy, which requires precise characterization of camera properties. Here, we provide guidance on choosing and characterizing a for SCOS, considering factors such as linearity, read noise, gain. We then validate...
We have developed the fiber-based speckle contrast optical spectroscopy (SCOS) system to measure human cerebral blood flow (CBF) and brain functions, demonstrated that SCOS outperforms traditional diffuse correlation (DCS) systems.
This paper outlines an FPGA VLSI design methodology that was used to realize a fully functioning chip in 130nm CMOS with improved routability and memory robustness. The architectural space exploration synthesis capability were enabled by the Verilog-to-Routing CAD tool. capabilities of this tool extended enable bitstream generation deployment. To validate architecture implementation, Chisel (Constructing Hardware Embedded Scala Language) model created rapidly verify microarchitectural...
We have developed a camera characterization protocol to estimate the parameters needed for estimation of fundamental speckle contrast in photon-starved optical spectroscopy (SCOS) systems.