A5068927878- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- T-cell and B-cell Immunology
- Pancreatic function and diabetes
- Heme Oxygenase-1 and Carbon Monoxide
- CO2 Reduction Techniques and Catalysts
- Cardiomyopathy and Myosin Studies
- RNA Interference and Gene Delivery
- Congenital Heart Disease Studies
- Cancer Research and Treatments
- 3D Printing in Biomedical Research
- Glioma Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Diabetes and associated disorders
- Cardiovascular Effects of Exercise
- Metal-Catalyzed Oxygenation Mechanisms
Whitman College
2025
City Of Hope National Medical Center
2022-2023
City of Hope
2021-2023
Beckman Research Institute
2021
Providence St. Mary Medical Center
2019
Massachusetts General Hospital
2015
Abstract Chimeric antigen receptor (CAR) T cells mediate potent antigen-specific antitumor activity; however, their indirect effects on the endogenous immune system are not well characterized. Remarkably, we demonstrate that CAR T-cell treatment of mouse syngeneic glioblastoma (GBM) activates intratumoral myeloid and induces memory responses coupled with feed-forward propagation responses. IFNγ production by responsiveness host critical for tumor landscape remodeling to promote a more...
Islet transplantation represents a potentially curative approach for individuals with Type I Diabetes. The requirement systemic immune suppression to control immune-mediated rejection of transplanted islets and the limited human islet supply represent significant roadblocks progress this approach. microencapsulation in alginate offers protection absence immunosuppression, but does not support long-term survival. chemokine, CXCL12, can repel effector T cells while recruiting...
Chimeric antigen receptor (CAR) T cell immunotherapy is emerging as a powerful strategy for cancer therapy; however, an important safety consideration the potential off-tumor recognition of normal tissue. This particularly ligand-based CARs are optimized clinical translation. Our group has developed and clinically translated IL13(E12Y) CAR targeting IL13Rα2 treatment glioblastoma (GBM). There remains limited understanding how IL13-ligand design impacts activity selectivity intended...
Short hairpin RNAs (shRNAs) have emerged as a powerful tool for gene knockdown in various cellular systems, including chimeric antigen receptor (CAR) T cells. However, the elements of shRNAs that are crucial their efficacy developing shRNA-containing CAR cells remain unclear. In this study, we evaluated impact different shRNA elements, promoter strength, orientation, multiple shRNAs, self-targeting, and sense antisense sequence composition on efficiency target Our findings highlight...
Abstract CAR T cell therapy is emerging as a promising strategy to treat cancer and may offer new therapeutic options for individuals diagnosed with glioblastoma (GBM) other solid tumors. While early clinical studies evaluating in GBM have established evidence of safety bioactivity, objective responses been limited. It remains unclear whether productive tumors requires solely engagement tumor antigen, or if it also necessitates the stimulation patient's endogenous immune response. Focusing...
<div>Abstract<p>Chimeric antigen receptor (CAR) T cells mediate potent antigen-specific antitumor activity; however, their indirect effects on the endogenous immune system are not well characterized. Remarkably, we demonstrate that CAR T-cell treatment of mouse syngeneic glioblastoma (GBM) activates intratumoral myeloid and induces memory responses coupled with feed-forward propagation responses. IFNγ production by responsiveness host critical for tumor landscape remodeling to...
<p>Supplementary Figures S1-S19</p>
<div>Abstract<p>Chimeric antigen receptor (CAR) T cells mediate potent antigen-specific antitumor activity; however, their indirect effects on the endogenous immune system are not well characterized. Remarkably, we demonstrate that CAR T-cell treatment of mouse syngeneic glioblastoma (GBM) activates intratumoral myeloid and induces memory responses coupled with feed-forward propagation responses. IFNγ production by responsiveness host critical for tumor landscape remodeling to...
<p>Supplementary Figures S1-S19</p>
<h3>Background</h3> Chimeric antigen receptor-(CAR) T cell therapy is seeing encouraging progress in solid tumors, however, factors such as the suppressive tumor microenvironment (TME) hinder its effectiveness.<sup>1</sup> We recently completed a phase I trial of IL13Rα2-targeted CAR-T cells for recurrent glioblastomas (GBM) and other high-grade gliomas, largest clinical study to date (NCT02208362).<sup>2–5</sup> Samples from this were evaluated TGFβ, an immunosuppressive cytokine highly...
Hypertrophic obstructive cardiomyopathy (HOCM) is a genetic condition most commonly characterized by hypertrophy of the ventricular septum, which leads to left ventricle outflow obstruction. Due severity condition, it often diagnosed in adolescents, especially those who exercise. We describe case 53-year-old male, previously undiagnosed with hypertrophic (HCM), became dyspneic during bike race. He was found have elevated troponin, pulmonary edema, and HOCM. The late presentation case, an...