A5102924317- Inorganic and Organometallic Chemistry
- Organometallic Complex Synthesis and Catalysis
- Synthesis and characterization of novel inorganic/organometallic compounds
- Magnetism in coordination complexes
- Crystal structures of chemical compounds
- Asymmetric Synthesis and Catalysis
- Metal complexes synthesis and properties
- Toxin Mechanisms and Immunotoxins
- Aldose Reductase and Taurine
- Hemoglobinopathies and Related Disorders
- Clostridium difficile and Clostridium perfringens research
- Diet, Metabolism, and Disease
- Iron Metabolism and Disorders
- Asymmetric Hydrogenation and Catalysis
- Crystallography and molecular interactions
- Polyoxometalates: Synthesis and Applications
- Chemical Synthesis and Reactions
- Trace Elements in Health
- Cancer, Hypoxia, and Metabolism
- Porphyrin and Phthalocyanine Chemistry
- Mitochondrial Function and Pathology
- Amino Acid Enzymes and Metabolism
- Organometallic Compounds Synthesis and Characterization
- Organic Chemistry Cycloaddition Reactions
- Metabolism and Genetic Disorders
University of Hull
2021
University College London
2018
Roche (United Kingdom)
2016-2017
California Institute of Technology
1997-2007
Howard Hughes Medical Institute
2002-2005
University of Pennsylvania
1996-1997
Johnson Foundation
1996
University of California, Los Angeles
1991-1994
Lawrence Berkeley National Laboratory
1992
Fusion Academy
1992
The comparison of monomeric and dimeric diphtheria toxin (DT) reveals a mode for protein association which we call domain swapping. structure DT has been extensively refined against data to 2.0-A resolution three-residue loop corrected as compared with our published 2.5-A-resolution structure. also determined, at 2.3-A resolution. Monomeric is Y-shaped molecule three domains: catalytic (C), transmembrane (T), receptor binding (R). Upon freezing in phosphate buffer, forms long-lived,...
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells and nonprostatic solid tumor neovasculature a target for anticancer imaging therapeutic agents. PSMA acts as glutamate carboxypeptidase (GCPII) on small molecule substrates, including folate, the drug methotrexate, neuropeptide N -acetyl- l -aspartyl- -glutamate. Here we present 3.5-Å crystal structure of ectodomain, which reveals homodimer with structural similarity to transferrin receptor, receptor...
The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, (Tf) and HFE, the protein mutated in hereditary hemochromatosis. A second Tf, TfR2, was recently identified found to be functional uptake transfected cells (Kawabata, H., Germain, R. S., Vuong, P. T., Nakamaki, Said, J. W., Koeffler, H. (2000) Biol. Chem. 275, 16618-16625). TfR2 has a pattern of expression regulation that is distinct from TfR, mutations have been recognized as cause non-HFE linked form...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemically Nonrigid Organometallic Compounds. I. π-Cyclopentadienyliron Dicarbonyl σ-Cyclopentadiene1M. J. Bennett Jr., F. A. Cotton, Davison, W. Faller, S. Lippard, and M. MorehouseCite this: Am. Chem. Soc. 1966, 88, 19, 4371–4376Publication Date (Print):October 1, 1966Publication History Published online1 May 2002Published inissue 1 October...
Abstract The structure of toxic monomeric diphtheria toxin (DT) was determined at 2.3 Å resolution by molecular replacement based on the domain structures in dimeric DT and refined to an R factor 20.7%. model consists 2 monomers asymmetric unit (1,046 amino acid residues), including bound adenylyl 3′‐5′ uridine 3′ monophosphate molecules 396 water molecules. 3 domains are virtually identical DT; however, is compact globular as compared “open” monomer within (Bennett MJ, Choe S, Eisenberg D,...
Abstract The refined structure of dimeric diphtheria toxin (DT) at 2.0 Å resolution, based on 37,727 unique reflections ( F > 1σ( )), yields a final R factor 19.5% with model obeying standard geometry. consists 523 amino acid residues, 1 molecule the bound dinucleotide inhibitor adenylyl 3′‐5′ uridine 3′ monophosphate (ApUp), and 405 well‐ordered water molecules. 2.0‐Å reveals that binding motif for ApUp includes residues in catalytic receptor‐binding domains is different from Rossmann...
Huntington's disease and several other neurological diseases are caused by expanded polyglutamine [poly(Gln)] tracts in different proteins. Mechanisms for (>36 Gln residues) poly(Gln) toxicity include the formation of aggregates that recruit sequester essential cellular proteins [Preisinger, E., Jordan, B. M., Kazantsev, A. & Housman, D. (1999) Phil. Trans. R. Soc. London B 354, 1029–1034; Chen, S., Berthelier, V., Yang, W. Wetzel, (2001) J. Mol. Biol. 311, 173–182] functional...
Background: Mammalian 3α-hydroxysteroid dehydrogenases (3α-HSDs) modulate the activities of steroid hormones by reversibly reducing their C3 ketone groups. In target tissues, 3α-HSDs act on 5α-dihydrotestosterone, a potent male sex hormone (androgen) implicated in benign prostate hyperplasia and cancer. Rat liver 3α-HSD belongs to aldo-keto reductase (AKR) superfamily provides model for mammalian 3α-, 17β- 20α-HSDs, which share >65% sequence identity. The determination structure complex with...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and x-ray structure of di-.mu.-hydrido-octacarbonyldirheniumM. J. Bennett, W. A. G. Graham, K. Hoyano, L. HutcheonCite this: Am. Chem. Soc. 1972, 94, 17, 6232–6233Publication Date (Print):August 1, 1972Publication History Published online1 May 2002Published inissue 1 August 1972https://pubs.acs.org/doi/10.1021/ja00772a072https://doi.org/10.1021/ja00772a072research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal structure of cesium tetrakis(hexafluoroacetylacetonato)yttrate(III). Novel stereoisomer having dodecahedral eight-coordinationM. J. Bennett, F. A. Cotton, P. Legzdins, and S. LippardCite this: Inorg. Chem. 1968, 7, 9, 1770–1776Publication Date (Print):September 1, 1968Publication History Published online1 May 2002Published inissue 1 September...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal and molecular structure of W2(CO)8H2{Si(C2H5)2}2. Compound containing a hydrogen-bridged transition metal-silicon bondM. J. Bennett K. A. SimpsonCite this: Am. Chem. Soc. 1971, 93, 26, 7156–7160Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/ja00755a008https://doi.org/10.1021/ja00755a008research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal and molecular structure of trirhenium nonaiodideM. J. Bennett, F. A. Cotton, Bruce M. FoxmanCite this: Inorg. Chem. 1968, 7, 8, 1563–1569Publication Date (Print):August 1, 1968Publication History Published online1 May 2002Published inissue 1 August 1968https://pubs.acs.org/doi/10.1021/ic50066a017https://doi.org/10.1021/ic50066a017research-articleACS PublicationsRequest reuse permissionsArticle Views159Altmetric-Citations51LEARN ABOUT THESE...
Rat liver 3α-hydroxysteroid/dihydrodiol dehydrogenase (3α-HSD) inactivates circulating steroid hormones and is involved in polycyclic aromatic hydrocarbon (PAH) carcinogenesis. It the only HSD of known structure aldo−keto reductase (AKR) superfamily may provide a paradigm for other mammalian HSDs this family. The 3α-HSD·NADP+ binary complex has been determined at 2.7 Å resolution refined to crystallographic R-factor 23.4% with good geometry. model similar complexes AKR that NADP+ binds...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeterodimetallic cycloheptatrienyl complexes of the transition metals: synthesis, properties, and structureM. J. Bennett, L. Pratt, K. A. Simpson, LiShingMan, Josef TakatsCite this: Am. Chem. Soc. 1976, 98, 16, 4810–4817Publication Date (Print):August 1, 1976Publication History Published online1 May 2002Published inissue 1 August 1976https://pubs.acs.org/doi/10.1021/ja00432a021https://doi.org/10.1021/ja00432a021research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLithium dimesitylborohydride bis(dimethoxyethane). New crystalline reagent for stereoselective reduction of ketonesJohn Hooz, S. Akiyama, F. J. Cedar, M. Bennett, and R. TuggleCite this: Am. Chem. Soc. 1974, 96, 1, 274–276Publication Date (Print):January 1974Publication History Published online1 May 2002Published inissue 1 January 1974https://pubs.acs.org/doi/10.1021/ja00808a057https://doi.org/10.1021/ja00808a057research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Rhenium-to-Rhenium Triple BondM. J. Bennett, F. A. Cotton, and R. WaltonCite this: Am. Chem. Soc. 1966, 88, 16, 3866–3867Publication Date (Print):August 1, 1966Publication History Published online1 May 2002Published inissue 1 August 1966https://pubs.acs.org/doi/10.1021/ja00968a039https://doi.org/10.1021/ja00968a039research-articleACS PublicationsRequest reuse permissionsArticle Views241Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular oxygen as a bridging ligand in transition metal complexM. J. Bennett and P. B. DonaldsonCite this: Am. Chem. Soc. 1971, 93, 13, 3307–3308Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/ja00742a048https://doi.org/10.1021/ja00742a048research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations46LEARN ABOUT THESE...