Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators their counter-regulatory molecules may be fundamental for determining the outcome of immune pathology periodontal disease. Transforming growth factor-β (TGF-β) vascular endothelial factor (VEGF) represent a family polypeptide proteins involved in regulation responses, especially rheumatic relationship these factors periodontitis has resulted new field osteoimmunology provides...

Integrins are heterodimeric cell surface membrane proteins linking the extracellular matrix to actin. α7B integrin is detected in proliferating and adult myofibers, whereas α7A plays a role regenerating muscle fibers with minor function mature fibers. The expression levels of β1A appear be very low, β1D appears predominant form muscle. Considering important features masseter we have studied specimens surgical patients posterior right crossbite comparing them left side specimens. Our results...

Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators their counter-regulatory molecules may be fundamental for determining the outcome of immune pathology periodontal disease. Cytokines play crucial roles in maintenance tissue homeostasis, a process which requires delicate anabolic catabolic activities. In particular, two families growth factors-such as transforming factor-β1 (TGF-β1) vascular endothelial factor (VEGF) are thought to...

Spinal cord injury (SCI) is a complex clinical and progressive condition characterized by neuronal loss, axonal destruction demyelination. In the last few years, adenosine receptors have been studied as target for many diseases, including neurodegenerative conditions. The aim of this study was to investigate effects an receptor agonist, PDRN, in experimental model SCI. Moreover, since stimulation may also activate Wnt pathway, we wanted PDRN on signaling following trauma induced extradural...

Varicocele is one of the main causes infertility in men. Oxidative stress and consequently apoptosis activation contribute to varicocele pathogenesis, worsening its prognosis. Natural products, such as lycopene, showed antioxidant anti-inflammatory effects several experimental models, also testes. In this study we investigated lycopene an model varicocele. Male rats (n = 14) underwent sham operations were administered with vehicle 7) or 7; 1 mg/kg i.p., daily). Another group animals surgical...

Cannabinoid receptors, which are widely distributed in the body, have been considered as possible pharmacological targets for management of several tumors. type 2 receptors (CB2Rs) belong to G protein-coupled receptor family and mainly expressed hematopoietic immune cells, such B-cells, T-cells, macrophages; thus, CB2R activation might be useful treating cancers affecting plasma multiple myeloma (MM). Previous studies shown that stimulation may anti-proliferative effects; therefore, purpose...

Many bioactive natural compounds are being increasingly used for therapeutics and nutraceutical applications to counteract male infertility, particularly varicocele. The roles of selenium Polydeoxyribonucleotide (PDRN) were investigated in an experimental model varicocele, with particular regard the role NLRP3 inflammasome. Male rats underwent sham operation daily administered vehicle, seleno-L-methionine (Se), PDRN, association Se-PDRN. Another group operated After twenty-eight days,...

In the present study, inkjet-printing (IJP) technique is used for development of a planar microwave sensor aimed at dielectric characterization biological samples. The proposed consists two capacitively coupled split-ring resonators (SRRs) fabricated using microstrip technology. A silver-based conductive ink deposited by IJP on conventional 1.6-mm-thick FR4 substrate, thus creating resonant structure. experimental analysis carried out considering water–ethanol mixture as test solution in...

The potential contribution of plasmacytoid dendritic cells (pDCs) in the presentation tumor cell Ags remains unclear, and some controversies exist with regard to ability pDCs phagocytose cell-derived particulate cross-present them MHC class I-restricted T lymphocytes. In this study, we show that human pDCs, although inefficient internalization membrane fragments by phagocytosis, can efficiently acquire patches associated molecules from cancer different histotypes. transfer occurred a very...

Cardiac fibrosis is a common pathological feature of different cardiovascular diseases, characterized by the aberrant deposition extracellular matrix (ECM) proteins in cardiac interstitium, myofibroblast differentiation and increased fibrillar collagen stimulated transforming growth factor (TGF)-β activation. Biglycan (BGN), small leucine-rich proteoglycan (SLRPG) integrated within ECM, plays key role assembly phenotypic control fibroblasts. Moreover, BGN critically involved remodeling...

Background/Objectives: Anterior disc displacement without reduction (ADDwoR) is a temporomandibular joint (TMJ) disorder characterized by progressive dysfunction and potential complications. Persistent leads to abnormal mechanical stress, predisposing the TMJ structural degeneration, including perforation. This case report aimed examine histological immunofluorescence characteristics of perforated tissue elucidate mechanisms contributing its pathology. Methods: A 50-year-old patient with...

Lycopene is a carotenoid found in tomatoes that has potent antioxidant activity. The Mediterranean diet particularly rich lycopene, which well-known beneficial effects on cardiovascular health. We tested the of lycopene extract group 20 ApoE knockout mice, fed with high fat western for 14 weeks. Starting from week 3 and up to 14, mice were randomly divided into two groups received (n = 10) by oral suspension every day at human equivalent dose 60 mg/day (0.246 mg/mouse/day), or vehicle...

Unilateral posterior crossbite is a widespread, asymmetric malocclusion characterized by an inverse relationship of the upper and lower buccal dental cusps, in molar premolar regions, on one side only arch. Patients with unilateral exhibit altered chewing cycles masseter results to be less active respect contralateral one. Few studies about morphological features masticatory muscle disorders exist most these have been performed animal models. The aim present study was evaluate protein...

Osteonecrosis of the jaw (ONJ) is an adverse effect bisphosphonate treatment that has become subject increasing investigations, in particular due to its poorly understood pathogenesis. Several experimental studies on animal models have been conducted; however, majority these replicate human ONJ following tooth extraction, and describe alterations bone gingival epithelium when necrosis manifested. The aim present study was analyze rat mandibular during 45 days zoledronate (which a agent),...

<p>Bone graft are used in dentistry for the reconstruction of severely atrophic jaws. Fresh frozen bone has no osteogenic property but it osteoconductive and osteoinductive properties because its matrix contains growth factors such as vascular endothelial factor. The purpose present study was to evaluate morphological protein expression characteristics fresh before after six months patients who needed maxillary reconstruction. After 6 month we observed presence viable evidenced by full...

The orthodontic tooth movement is the last step of several biological processes that take place after application external forces. During this process, dental pulp tissue subjected to structural and protein expression modifications in order maintain their integrity functional morphology. purpose present work was perform an vivo study, evaluating human patients have undergone due pre-calibrated light force for 30 days. Dental samples were extracted from molars premolars control group 7 days...

The sarcoglycan complex, consisting of α-, β-, γ-, δ- and ε-sarcoglycans, is a multimember transmembrane system providing mechanosignaling connection from the cytoskeleton to extracellular matrix. Whereas expression α- γ-sarcoglycan restricted striated muscle, other sarcoglycans are widely expressed. Although many studies have investigated in all muscle types, insufficient data available on distribution complex nonmuscle tissue. On this basis, we used immunohistochemical RT-PCR techniques...

The sarcoglycan complex consists of a group single-pass transmembrane glycoproteins that are essential to maintain the integrity muscle membranes. Any mutation in each gene causes series recessive autosomal dystrophin-positive muscular dystrophies. Negative fibres for sarcoglycans have never been found healthy humans and animals. In this study, we investigated whether social ranking has an influence on expression skeletal muscles baboons. Biopsies masseter sternocleidomastoid were processed...

Diffusion tensor imaging (DTI) is a non-invasive MR technique widely employed to study muscle anatomy. DTI parameters have been used investigate microstructural changes dependent on demographic factors or transient condition such as exercise. The present aimed at investigating the diffusion of human calf muscles after 3-months strength training protocol.Ten young men were trained for improving size and medial (GCM), lateral gastrocnemius (GCL) soleus (SL) three times week, with least 24...

Endocan is a small soluble proteoglycan (PG) known to be involved in inflammation and angiogenesis. Increased endocan expression was found the synovia of arthritic patients chondrocytes stimulated with IL-1ß. Considering these findings, we aimed investigate effects knockdown on modulation pro-angiogenic molecules model IL-1ß-induced human articular chondrocytes. Endocan, VEGF-A, MMP-9, MMP-13, VEGFR-2 measured both normal NF-kB activation were also measured. Results have shown that endocan,...

The inkjet printing (IJP) is a highly attractive technology, consisting in the deposition of ink layers on flexible or rigid substrates. IJP technology used present study to develop planar microstrip sensor aimed at dielectric characterization biological samples, such as cell cultures. In this contribution we focused constant solution under test (i.e., real part complex relative permittivity). proposed consists two capacitive coupled ring resonators, which are achieved by silver-based...

Regular training programs are a concrete means to prevent and/or reduce functional decline due aging. A multisensory approach seems obtain better results in the elderly with regard both balance and quality of life. Forty subjects (age 65±10 years, height 165±4 cm, weight 73.0±4.6 kg) were randomized into two groups (GrHu GrCl). Participants GrHu group received 3 months postural training, sessions per week, use approach. Those GrCl classical rehabilitation protocol that included isotonic for...

A unilateral posterior crossbite is a malocclusion where the low activity of affected masseter muscle compensated by contralateral hypertrophy. It still unknown if, in same condition, myogenesis with new fibre formation takes place. Aim: aim present study was to evaluate expression markers, such as Myf5 and MyoD, muscles patients. Materials methods: biopsies from fifteen surgical patients crossbites have been analysed immunofluorescence reactions. The results show MyoD but not ipsilateral...

Obesity is considered one of the main risk factors for cardiovascular diseases. The browning process has been recently recognized as a promising anti-obesity therapy. Lycopene (LYC) and Garcinia cambogia fruit extract (GE) might be important resources drugs; therefore, aim this study was to investigate effects LYC GE on 3T3-L1 adipocytes Zucker rats. Mouse pre-adipocytes were differentiated in mature then treated with (0.5 μM), (30 mg/mL) or + 24 h. Moreover, male Crl:ZUC-Leprfa rats...