A5070029054- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Chronic Myeloid Leukemia Treatments
- Cytomegalovirus and herpesvirus research
- Antifungal resistance and susceptibility
- Chronic Lymphocytic Leukemia Research
- Renal Transplantation Outcomes and Treatments
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Fungal Infections and Studies
- Glycosylation and Glycoproteins Research
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- Childhood Cancer Survivors' Quality of Life
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- RNA Interference and Gene Delivery
- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
University Niccolò Cusano
2024-2025
University of Perugia
2015-2024
Ospedale Santa Maria
2011-2023
Bernstein Center for Computational Neuroscience Tübingen
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Perugia
2021
European Society for Blood and Marrow Transplantation
2014
European Society for Organ Transplantation
2009-2013
Istituti di Ricovero e Cura a Carattere Scientifico
2007
Institute of Neurobiology and Molecular Medicine
2004-2006
Weizmann Institute of Science
2002-2005
T cells that accompany allogeneic hematopoietic grafts for treating leukemia enhance engraftment and mediate the graft-versus-leukemia effect. Unfortunately, alloreactive also cause graft-versus-host disease (GVHD). cell depletion prevents GVHD but increases risk of graft rejection leukemic relapse. In human transplants, we show donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate relapse protect patients against GVHD. mice, pretransplant infusion NK obviated need...
In this study we tried to achieve successful transplantation in patients with acute leukemia the use of hematopoietic stem cells from donors who shared only one HLA haplotype recipient (a “full-haplotype mismatch”). To prevent graft failure, large doses T-cell–depleted were transplanted after a conditioning regimen enhanced myeloablation and immunosuppression was administered recipient.
Purpose Establishment of hematopoietic stem-cell (HSC) transplantation from mismatched relatives is feasible for patients with acute leukemia. As our original method graft processing was unsuitable large-scale clinical studies, we use automated devices CD34+ cell purification. Patients and Methods Sixty-seven myeloid leukemia (AML; 19 complete remission [CR] 1, 14 CR 2, nine > 25 in relapse) 37 lymphoid (ALL; eight two 13 were conditioned total-body irradiation, thiotepa, fludarabine,...
NK cells use a variety of receptors to detect abnormal cells, including tumors and their metastases. However, in the case melanoma, it remains be determined what specific molecular interactions are involved whether control metastatic progression and/or route dissemination. Here we show that human melanoma cell lines derived from LN metastases express ligands for natural cytotoxicity (NCRs) DNAX accessory molecule-1 (DNAM-1), two emerging key cancer recognition, but not group 2 member D...
The soluble pattern-recognition receptor known as long pentraxin 3 (PTX3) has a nonredundant role in antifungal immunity. contribution of single-nucleotide polymorphisms (SNPs) PTX3 to the development invasive aspergillosis is unknown.
<h2>Abstract</h2> Matching for HLA class I alleles, including HLA-C, is an important criterion outcome of unrelated donor transplantation. However, haplotype-mismatched transplantations myeloid malignancies, mismatched killer immunoglobulin-like receptor (KIR) ligands in the graft-versus-host (GVH) direction, associated with lower rates disease (GVHD), relapse, and mortality. This study investigated effect KIR ligand mismatching on The outcomes after 1571 malignancies where donor–recipient...