A5103032745- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- Acute Lymphoblastic Leukemia research
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Leptospirosis research and findings
- Galectins and Cancer Biology
- Biomarkers in Disease Mechanisms
- Immune Response and Inflammation
- RNA modifications and cancer
- Chronic Myeloid Leukemia Treatments
- Diabetes and associated disorders
- Chemokine receptors and signaling
- Mesenchymal stem cell research
- Circadian rhythm and melatonin
- Protein Tyrosine Phosphatases
- Skin Protection and Aging
- Monoclonal and Polyclonal Antibodies Research
- Infectious Diseases and Mycology
Cancer Institute (WIA)
2020
CRUK Lung Cancer Centre of Excellence
2016-2020
University College London
2014-2019
Centre for Immunity, Infection and Evolution
2019
The Royal Free Hospital
2015-2016
Science for Life Laboratory
2014
Uppsala University
2014
Hospital de Santa Maria
2014
University of Lisbon
2014
The soluble pattern-recognition receptor known as long pentraxin 3 (PTX3) has a nonredundant role in antifungal immunity. contribution of single-nucleotide polymorphisms (SNPs) PTX3 to the development invasive aspergillosis is unknown.
G-SCF–mobilized CD34 + monocytes inhibit graft-versus-host disease by the production of nitric oxide and induction regulatory T cells.
A dense population of embryo-derived Langerhans cells (eLCs) is maintained within the sealed epidermis without contribution from circulating cells. When this network perturbed by transient exposure to ultraviolet light, short-term LCs are temporarily reconstituted an initial wave monocytes but thought be superseded more permanent repopulation with undefined LC precursors. However, extent which process relevant immunopathological processes that damage integrity not known. Using a model...
A key predictor for the success of gene-modified T cell therapies cancer is persistence transferred cells in patient. The propensity less differentiated memory to expand and survive efficiently has therefore made them attractive candidates clinical application. We hypothesized that redirecting specialized niches BM support differentiation would confer increased therapeutic efficacy. show overexpression chemokine receptor CXCR4 CD8+ (TCXCR4) enhanced their migration toward vascular-associated...
Acute graft-versus-host disease (GVHD) is initially triggered by alloreactive T cells, which damage peripheral tissues and lymphoid organs. Subsequent transition to chronic GVHD involves the emergence of autoimmunity, although underlying mechanisms driving this process are unclear. Here, we tested hypothesis that acute blocks tolerance autoreactive cells impairing lymph node (LN) display tissue–restricted antigens (PTAs). At initiation GVHD, LN fibroblastic reticular (FRCs) rapidly reduced...
Graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic stem cell transplantation induced by the influx donor-derived effector T cells (TE) into peripheral tissues. Current treatment strategies rely on targeting systemic cells; however, precise location and nature instructions that program TE to become pathogenic trigger injury are unknown. We therefore used weighted gene coexpression network analysis construct an unbiased spatial map differentiation during...
Abstract A key challenge in the field of T-cell immunotherapy for cancer is creating a suitable platform promoting differentiation effector cells while at same time enabling self-renewal needed long-term memory. Although transfer less differentiated memory T increases efficacy through greater expansion and persistence vivo, capacity such to sustain functions within immunosuppressive tumor microenvironments may still be limiting. We have therefore directly compared impact versus therapeutic...
Abstract Background Constitutive activation of the ERK pathway, occurring in vast majority melanocytic neoplasms, has a pivotal role melanoma development. Different mechanisms underlie this different tumour settings. The Grey phenotype horses, caused by 4.6 kb duplication intron 6 Syntaxin 17 ( STX17 ), is associated with very high incidence cutaneous melanoma, but molecular mechanism behind melanomagenesis remains unknown. Here, we investigated involvement pathway development horses....
Dendritic cells (DCs) play a vital role in innate and adaptive immunities. Inducible depletion of CD11c(+) DCs engineered to express high-affinity diphtheria toxin receptor has been powerful tool dissect DC function vivo. However, despite reports showing that loss induces transient monocytosis, the monocyte population emerges potential impact monocytes on studies have not investigated. We found from CD11c.DTR mice induced expansion variant CD64(+) Ly6C(+) spleen blood was distinct...
It is not known why only certain tissues are prone to GVHD injury following allogeneic hematopoietic stem cell transplantation despite widespread antigen expression. Clinical patterns of also diverse, with individual organs showing highly variable responses immunosuppressive therapy. Although it that T effector pathways can have distinct effects upon target organs, there has been no unbiased or systems-wide approach defining the cellular and molecular mechanisms underlying tissue-specific...
<p>Supplementary methods for flow cytometry and retroviral construct generation. Supplementary Figure 1. Expression of activated caspase-3 in CD8+ T cells overexpressing RHEB or PRAS40. 2. CD25 CD69 3. killer cell lectin-like receptor subfamily G member 1 4. Recall immunity is impaired 5. GFP induction with Doxycycline transduced iGFP iPRAS vectors. 6. Levels phosphorylated S6 after stimulation pMP71-PRAS40 pMP71-vector control. 7. Frequency expressing shRNAs against mTOR Raptor...
<p>Supplementary methods for flow cytometry and retroviral construct generation. Supplementary Figure 1. Expression of activated caspase-3 in CD8+ T cells overexpressing RHEB or PRAS40. 2. CD25 CD69 3. killer cell lectin-like receptor subfamily G member 1 4. Recall immunity is impaired 5. GFP induction with Doxycycline transduced iGFP iPRAS vectors. 6. Levels phosphorylated S6 after stimulation pMP71-PRAS40 pMP71-vector control. 7. Frequency expressing shRNAs against mTOR Raptor...
<div>Abstract<p>A key challenge in the field of T-cell immunotherapy for cancer is creating a suitable platform promoting differentiation effector cells while at same time enabling self-renewal needed long-term memory. Although transfer less differentiated memory T increases efficacy through greater expansion and persistence <i>in vivo</i>, capacity such to sustain functions within immunosuppressive tumor microenvironments may still be limiting. We have therefore...
<div>Abstract<p>A key challenge in the field of T-cell immunotherapy for cancer is creating a suitable platform promoting differentiation effector cells while at same time enabling self-renewal needed long-term memory. Although transfer less differentiated memory T increases efficacy through greater expansion and persistence <i>in vivo</i>, capacity such to sustain functions within immunosuppressive tumor microenvironments may still be limiting. We have therefore...
Abstract Embryo-derived Langerhans cells (eLC) are maintained within the sealed epidermis without contribution from circulating cells. When network is perturbed by transient exposure to ultra-violet light, short-term LC temporarily reconstituted an initial wave of monocytes, but thought be superseded more permanent repopulation with undefined precursors. However, extent which this mechanism relevant immune-pathological processes that damage population integrity not known. Using a model...