A5076890130- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Adipose Tissue and Metabolism
- Chronic Kidney Disease and Diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Body Composition Measurement Techniques
- Attention Deficit Hyperactivity Disorder
- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Diabetes Management and Education
- Thermoregulation and physiological responses
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Health and Lifestyle Studies
- Hemodynamic Monitoring and Therapy
University of California, San Francisco
2022-2025
San Francisco VA Health Care System
2024-2025
University of California San Francisco Medical Center
2024
San Francisco VA Medical Center
2024
Universidad Anáhuac
2017-2021
Washington University in St. Louis
2020
Background: Individual kidney tubule biomarkers are associated with risks for chronic disease (CKD) progression and mortality in persons diabetes. Integrating multiple using a latent variable method of exploratory factor analysis could define distinct dimensions health, their associations adverse outcomes. Methods: We conducted 17 candidate urine plasma 1,256 participants diabetes estimated glomerular filtration rate (eGFR) <60ml/min/1.73 m 2 from the Chronic Renal Insufficiency Cohort...
Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements adiponectin/leptin ratio (ALR), adipo-insulin index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping direct F/P differential...
Cardiovascular disease (CVD) and type 2 diabetes (T2D) are increasing worldwide. This is mainly due to an unhealthy nutrition, implying that variation in CVD risk may be the capacity manage a nutritional load. We examined genomic basis of postprandial metabolism. Our main purpose was introduce GEMM Family Study (Genetics Metabolic Diseases Mexico) as multi-center study carrying out ongoing recruitment healthy urban adults. Each participant received mixed meal challenge provided 5-hours’ time...
Overweight children and childhood obesity are a public health problem in Mexico. Obesity is traditionally assessed using body mass index (BMI), but an excess of adiposity does not necessarily reflect high BMI. Thus, composition indexes better alternative. Our objective was to generate percentile curves from Mexico City. A total 2026 boys 1488 girls aged 6 12 years old were studied Body weight, height, BMI calculation measured. Total fat percentage (TBFP) derived the skinfold thicknesses,...
This study aimed to evaluate markers of the CLOCK gene rs1801260 and rs4864548 in Mexican adolescents, addressing clinical biological aspects previously associated with ADHD. 347 adolescents were assessed for mental disorders, metabolic disruption related conditions, circadian preference, as well genotyping CLOCK. We found a significant association between ADHD AA AG genotypes rs1801260. Also, we identified group that total Triiodothyronine Thyroxine values respectively 10 ng/dl units 0.58...
We previously reported preliminary characterization of adipose tissue (AT) dysfunction through the adiponectin/leptin ratio (ALR) and fasting/postprandial (F/P) gene expression in subcutaneous (SQ) biopsies obtained from participants GEMM study, a precision medicine research project. Here we present integrative data replication previous findings an increased number symptom-free (SF) adults (N = 124) to improve early biomarkers for cardiovascular (CV)/immunometabolic risk SF with AT...
Abstract Obesity remains as a global epidemic characterized by progressive metabolic dysregulation in glucose homeostasis. Along with genetic association the development of T2D, epigenetic regulation has been suggested significant contributor altered gene expression. Recent studies have described DNA methylation changes insulin-sensitive tissues involved T2D pathogenesis, however dynamics on early stages to alterations is still unclear. We investigated potential signatures 34 asymptomatic...