A5014616863- Wound Healing and Treatments
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
- Body Contouring and Surgery
- Antimicrobial Peptides and Activities
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Osteoarthritis Treatment and Mechanisms
- Nonmelanoma Skin Cancer Studies
- Diagnosis and Treatment of Venous Diseases
- Periodontal Regeneration and Treatments
- Health, Work, and Social Studies in Poland
- Orthopedic Surgery and Rehabilitation
- Antioxidant Activity and Oxidative Stress
- MicroRNA in disease regulation
- Leech Biology and Applications
- Surgical Sutures and Adhesives
- Bone fractures and treatments
- 3D Printing in Biomedical Research
- Diabetic Foot Ulcer Assessment and Management
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Global Healthcare and Medical Tourism
- Cutaneous Melanoma Detection and Management
Gdańsk Medical University
2010-2024
Non-healing wounds and skin losses constitute significant challenges for modern medicine pharmacology. Conventional methods of wound treatment are effective in basic healthcare; however, they insufficient managing chronic large defects, so novel, alternative therapy sought. Among the potentially innovative procedures, use substitutes may be a promising therapeutic method. Skin heterogeneous group materials that used to heal close temporarily or permanently fulfill functions skin....
Objective: This study evaluated the use of novel peptides derived from platelet-derived growth factor (PDGF-BB) as potential wound healing stimulants. One compounds (named PDGF2) was subjected for further research after cytotoxicity and proliferation assays on human skin cells. Further investigation included evaluation of: migration chemotaxis cells, immunological allergic safety, transcriptional analyses adipose-derived stem cells (ASCs) dermal fibroblasts stimulated with PDGF2, dorsal...
Abstract Adipose-derived stem cells (ASCs) have become an important research model in regenerative medicine. However, there are controversies regarding the impact of prolonged cell culture on ASCs phenotype and their differentiation potential. Hence, we studied 10 clinical replicates from plastic oncological surgery patients, six-passage FBS supplemented cultures. We quantified basic mesenchymal surface marker transcripts encoded proteins after each passage. In parallel, investigated...
Introduction Only in 2023 solid organs were transplanted 1400 patients Poland. Nonmelanoma skin cancer such as squamous cell carcinoma (SCC) or basal (BCC) is the most common malignancy organ transplant recipients (SOTR). The aim of study to present cases and discuss possible course after transplantation. Case presentation involved 3 transplantation treated for Department Plastic Surgery University Gdańsk years 2020-2023. Each patient an example a different disease. In case with...
ESC (epidermal stem cells) play a central role in the regeneration of human epidermis. These cells are also responsible for wound healing and neoplasm formation. Efficient isolation allows their use medicine pharmacy as well basic science. Cultured keratinocytes may be used biological dressing burn injuries, chronic wounds hereditary disorders. Therefore, characterization have been goals biomedical Here, we present flow cytometric method analysis candidates. The strategy presented combines...
Regeneration and wound healing are vital to tissue homeostasis organism survival. One of the biggest challenges today’s science medicine is finding methods factors stimulate these processes in human body. Effective solutions promote regenerative responses will accelerate advances engineering, medicine, transplantology, a number other clinical specialties. In this study, we assessed potential efficacy synthetic hexapeptide, RDKVYR, for stimulation repair healing. The hexapeptide marketed...
Background: Wound healing complications affect numerous patients each year, creating significant economic and medical challenges. Currently, available methods are not fully effective in the treatment of chronic or complicated wounds; thus, new constantly sought. Our previous studies showed that a peptide designated as PDGF2 derived from PDGF-BB could be promising drug candidate for wound RADA16-I can serve release system bioactive peptides healing. Based on that, this work, we designed...
Abstract Tocopherols and tocotrienols have been extensively studied owing to their anticancer potential, especially against breast cancer. Therefore, the aim of this study was quantitatively determine tocochromanols in human adipose tissue with use HPLC–FLD. The sample preparation procedure included homogenization solvent extraction isopropanol–ethanol–0.1% formic acid mixture prior solid‐phase extraction. After implementation central composite design, satisfactory separation all eight...
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Skin aging and human body are natural processes that occur in every organism. The observed changes include loss of hydration elasticity, as well thinning the skin, resulting visible wrinkles, lowering tip nose, fat tissue temples cheeks, sagging lateral parts muscle bone atrophy. Preventing aging, slowing down degenerative soft tissues, addressing their initial signs focus aesthetic medicine. It is a branch medicine offers non-surgical procedures, yet they still invasive. article discusses...
Degloving injuries are traumatic avulsions usually resulting in large areas of soft tissue defects. The injury involves separation skin and subcutaneous from fascia muscles. complex nature these requires a patient-oriented multidisciplinary surgical approach wide variety therapeutic options. Negative pressure wound therapy can be benefit at every stage the long-lasting treatment.
 In this paper, we present case 29-year-old male after an occupational accident with conveyor belt leading...