A5081124399- Genetic Associations and Epidemiology
- Machine Learning in Bioinformatics
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Gut microbiota and health
- Aquaculture disease management and microbiota
- Ion-surface interactions and analysis
- Autism Spectrum Disorder Research
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Child Nutrition and Feeding Issues
- Mass Spectrometry Techniques and Applications
- Neuroendocrine regulation and behavior
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Alzheimer's disease research and treatments
- Climate Change and Health Impacts
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- Metabolomics and Mass Spectrometry Studies
- Ion Transport and Channel Regulation
Foshan Maternity and Child Health Care Hospital
2009-2025
Universiti Putra Malaysia
2025
Henan Psychiatric Hospital
2019-2024
Xinxiang Medical University
2019-2024
Henan Academy of Sciences
2024
Guangdong Medical College
2024
Guangzhou Medical University
2011-2024
Huazhong University of Science and Technology
2020-2024
Fudan University
2021-2023
Sun Yat-sen University
2021-2023
Abstract Establishing an RNA-associated interaction repository facilitates the system-level understanding of RNA functions. However, as these interactions are distributed throughout various resources, essential prerequisite for effectively applying data requires that they deposited together and annotated with confidence scores. Hence, we have updated database RNAInter (RNA Interactome Database) to version 4.0, which is freely accessible at http://www.rnainter.org or...
Recent advances in spatial transcriptomics (ST) have brought unprecedented opportunities to understand tissue organization and function context. However, it is still challenging precisely dissect domains with similar gene expression histology situ. Here, we present DeepST, an accurate universal deep learning framework identify domains, which performs better than the existing state-of-the-art methods on benchmarking datasets of human dorsolateral prefrontal cortex. Further testing a breast...
Abstract Background Dietary and gastrointestinal (GI) problems have been frequently reported in autism spectrum disorder (ASD). However, the relative contributions of autism-linked traits to dietary GI children with ASD are poorly understood. This study firstly compared intake symptoms between typically developing (TDC), then quantified intake, within group. Methods A sample 121 age-matched TDC were eligible for this study. The indicators included food groups intakes, variety, diet quality....
Abstract Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to complicated gene regulatory mechanisms complexity of linkage disequilibrium (LD), biological by which exert their effects on depression remain largely unknown. Here, we perform a transcriptome-wide study (TWAS) integrating GWAS summary statistics from 807,553 individuals (246,363...
Heavy metal cadmium (Cd) pollution is a serious problem affecting the sustainable development of aquaculture and safety aquatic foods. Research about use probiotics to attenuate toxic damage caused by Cd
Probiotics have been widely used in aquaculture and may serve as a potential alternative to antibiotics. Diverse sources of probiotics different effects on the host, application native isolated from target fish play better role. This study was conducted evaluate probiotic bacteria gut common carp (Cyprinus carpio L.). Based morphological, 16 S rRNA sequencing whole-genome analysis, an strain that simultaneously produces protease, mannanase, amylase, cellulose identified Bacillus velezensis...
Schizophrenia is characterized by several core behavioral features, in which the gastrointestinal symptoms are frequently reported. Maternal immune activation (MIA) has been developed a rodent model to study neurodevelopmental disorders such as schizophrenia. However, changes gut environment of MIA rats remain largely unknown.10 mg/kg polyinosinic:polycytidylic acid (Poly I:C) on gestational day 9 was intravenously administered induce order assess behavior, intestinal barrier and microbiota...
The ongoing pandemic of COVID-19 is still affecting our life, but the effects lockdown measures on gestational diabetes mellitus (GDM) in pregnant women remain unclear.To investigate association between and GDM.Medical records 140844 during 2015-2020 were extracted from 5 hospitals Guangdong Province, China. Pregnant who underwent Level I (1/23 - 2/24/2020) pregnancy defined as exposed group (N=20472) same calendar months 2015-2019 2/24) unexposed (N=120372). Subgroup analyses used to...
Renal fibrosis commonly occurs in the process of chronic kidney diseases. Here, we explored role Jumonji domain containing 3 (Jmjd3)/interferon regulatory factor 4 (IRF4) axis activation myeloid fibroblasts and transition M2 macrophages into myofibroblasts (M2MMT) fibrosis. In mice, Jmjd3 IRF4 were highly induced interstitial cells kidneys with folic acid or obstructive injury. deletion inhibitor reduced levels injured kidneys. Myeloid depletion impaired bone marrow-derived M2MMT...
As a means to aid in the investigation of viral infection mechanisms and identification more effective antivirus targets, availability source which continually collects updates information on virus host ncRNA-associated interaction resources is essential. Here, we update ViRBase database version 3.0 (http://www.virbase.org/ or http://www.rna-society.org/virbase/). This represents major revision: (i) total number entries now greater than 820,000, an approximately 70-fold increment, involving...
Antipsychotic drug treatment for schizophrenia (SZ) can alter brain structure and function, but it is unclear if specific regional changes are associated with outcome. Therefore, we examined the effects of antipsychotic on grey matter (GM) density, white (WM) functional connectivity (FC) as well associations between efficacy. SZ patients (n = 163) health controls (HCs) 131) were by structural magnetic resonance imaging (sMRI) at baseline, a subset 77) re-examined after 8 weeks...
Renal fibrosis is an important pathological biomarker of chronic kidney disease (CKD). Stimulator interferon genes/TANK binding kinase 1 (STING/TBK1) axis has been identified as the main regulator innate immune response and closely related to fibrotic disorder. However, role STING/TBK1 signaling pathway in still unknown. In this study, we investigated effect pharmacological inhibition on renal induced by folic acid (FA). mice, TBK1 was significantly activated interstitial cells FA-injured...
Children with autism spectrum disorder (ASD) are at high risk of experiencing externalizing and internalizing problems. This study aimed to reveal how maternal parenting styles autistic traits influence behavioral problems in children ASD.This recruited 70 2-5 years ASD 98 typically developing (TD) children. The Parental Behavior Inventory (PBI) Autism Spectrum Quotient (AQ) were used collect the traits, respectively. children's reported by mothers using Strengths Difficulties Questionnaire...