A5073787078- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Abdominal Surgery and Complications
- Cardiac Arrest and Resuscitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Kidney Disease and Diabetes
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Airway Management and Intubation Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Eicosanoids and Hypertension Pharmacology
- Inflammasome and immune disorders
- Organ Transplantation Techniques and Outcomes
- Pancreatitis Pathology and Treatment
- Aortic aneurysm repair treatments
- Abdominal vascular conditions and treatments
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
University of Florida
2020
Columbus Oncology and Hematology Associates
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Southern Medical University
2016
Nanfang Hospital
2016
University of Chicago Medical Center
2014
Molecular Oncology (United States)
2014
Marymount University
2012-2013
Intestinal ischemia-reperfusion (I/R) injury is a devastating complication in the perioperative period. Dexmedetomidine commonly applied The authors aimed to determine effects of different doses dexmedetomidine (given before or after intestinal ischemia) on I/R and explore underlying mechanisms.Intestinal was produced rat by clamping superior mesenteric artery for 1 h followed 2 reperfusion. Intravenous infusion performed at 2.5, 5, 10 μg · kg(-1) h(-1) ischemic insult. In addition,...
Remote ischemic preconditioning (RIPC) may confer the cytoprotection in critical organs. The authors hypothesized that limb RIPC would reduce intestinal and pulmonary injury patients undergoing open infrarenal abdominal aortic aneurysm repair.In this single-center, prospective, double-blinded, randomized, parallel-controlled trial, 62 elective repair were randomly assigned a 1:1 ratio by computerized block randomization to receive or conventional (control). Three cycles of 5-min...
Reperfusion of the ischemic intestine often leads to drive distant organ injury, especially injuries associated with hepatocellular dysfunction. The precise molecular mechanisms and effective multiple protection strategies remain be developed. In current study, significant remote liver dysfunction was found after 6 hours reperfusion according increased histopathological scores, serum lactate dehydrogenase (LDH), alanine aminotransferase (ALT)/aspartate (AST) levels, as well enhanced...
Influx of activated neutrophils into the lungs is histopathologic hallmark acute lung injury (ALI) after intestinal ischemia/reperfusion (I/R). Neutrophils can release DNA and granular proteins to form cytotoxic neutrophil extracellular traps (NETs), which promotes bystander tissue injury. However, whether NETs are responsible for remote ALI I/R mechanisms underlying dissemination harmful gut-derived mediators unknown. In C57BL/6J mouse model, DNase I-mediated degradation protein arginine...
BACKGROUND: Myocardial infarction is a common perioperative complication, and blood flow restoration causes ischemia/reperfusion injury (IRI). Dexmedetomidine (DEX) pretreatment can protect against cardiac IRI, but the mechanism still insufficiently understood. METHODS: In vivo, myocardial (30 minutes/120 minutes) was induced via ligation then reperfusion of left anterior descending coronary artery (LAD) in mice. Intravenous infusion 10 μg/kg DEX performed 20 minutes before ligation....
Matrine is a component of the traditional Chinese medical herb Sophora flavescens Ait, which widely used to treat diseases such as viral hepatitis, cardiac arrhythmia and skin inflammations. As indicated by previous reports, molecular mechanism matrine's anti-cancer effect has been poorly clarified. In this study, we both in vitro vivo models investigate antitumor its possible mechanisms. Murine hepatocellular carcinoma H22 cells were cultured presence matrine at various concentrations (0.2...
Cell death is an important biological process that believed to have a central role in intestinal ischaemia/reperfusion (I/R) injury. While the apoptosis inhibition pivotal preventing I/R, how necrotic cell regulated remains unknown. Necroptosis represents newly discovered form of programmed combines features both and necrosis, it has been implicated development range inflammatory diseases. Here, we show receptor-interacting protein 1/3 (RIP1/3) kinase mixed lineage domain-like recruitment...
Abstract Background Small hepatocellular carcinoma (sHCC) is a special subtype of HCC with the maximum tumor diameter ≤ 3 cm and excellent long-term outcomes. Surgical resection or radiofrequency ablation provides greatest chance for cure; however, many patients still undergo recurrence after primary treatment. To date, there no clinical applicable method to assess biological aggressiveness in solitary sHCC. Methods In current study, we retrospectively evaluated necrosis 335 sHCC treated...
The mortality of critically ill patients associated with intestinal ischemia/reperfusion remains very high, which results from multiorgan dysfunction or failure due to injury induced by ischemia/reperfusion. This study was carried out investigate whether can cause cerebral and concomitant memory dysfunction, explore the potential mechanisms.Prospective, controlled, randomized animal study.University research laboratory.Male, adult Sprague-Dawley rats (weighing 250-300 g).Intestinal...
The present study attempts to evaluate the role of Janus kinase/signal transducer and activator transcription (JAK/STAT) signaling in intestinal ischemia/reperfusion (I/R)-induced injury whether immediate ischemic postconditioning ameliorates via attenuation mucosal apoptosis subsequent inhibiting JAK/STAT activation. Anesthetized adult male Sprague-Dawley rats were subjected superior mesenteric artery occlusion consisting 60 min ischemia 2 h reperfusion; sham laparotomy served as controls....
Abstract Intestinal ischemia/reperfusion (I/R) injury remains a major clinical event and contributes to high morbidity mortality rates, but the underlying mechanisms remain elusive. Recent studies have demonstrated that microRNAs (miRNAs) important roles in organ I/R injury, changes potential of miRNAs intestinal I/R-induced are unclear. This study was designed analyze miRNA expression profiles mucosa after explore role target during this process. Using microarray analysis, we found 19 from...
Intestinal ischemia/reperfusion (I/R) injury, in which macrophages play a key role, can cause high morbidity and mortality. The switch from classically (M1) to alternatively (M2) activated macrophages, is dependent on the activation of STAT6 signaling, has been shown protect organs I/R injuries. In current study, effects recombinant Trichinella spiralis cathepsin B-like protein (rTsCPB) intestinal injury potential mechanism related macrophage phenotypes were investigated. mouse model...
Renal fibrosis commonly occurs in the process of chronic kidney diseases. Here, we explored role Jumonji domain containing 3 (Jmjd3)/interferon regulatory factor 4 (IRF4) axis activation myeloid fibroblasts and transition M2 macrophages into myofibroblasts (M2MMT) fibrosis. In mice, Jmjd3 IRF4 were highly induced interstitial cells kidneys with folic acid or obstructive injury. deletion inhibitor reduced levels injured kidneys. Myeloid depletion impaired bone marrow-derived M2MMT...
Intestinal ischemia/reperfusion (I/R) challenge often results in gut barrier dysfunction and induces distant organ injury. Dexmedetomidine has been shown to protect intestinal epithelial against I/R attack. The present study aims investigate the degree which attack will contribute gut-vascular (GVB) damage, examine ability of dexmedetomidine minimize GVB liver injuries mice.In vivo, ischemic was induced mice by clamping superior mesenteric artery for 45 minutes. After clamping, were...