A5014084670- Salmonella and Campylobacter epidemiology
- Lung Cancer Treatments and Mutations
- Food Safety and Hygiene
- Meat and Animal Product Quality
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Listeria monocytogenes in Food Safety
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Cancer survivorship and care
- PI3K/AKT/mTOR signaling in cancer
- Lymphatic System and Diseases
- Animal Nutrition and Physiology
- Parasitic Diseases Research and Treatment
- Cancer Mechanisms and Therapy
- Cancer Diagnosis and Treatment
- Parasite Biology and Host Interactions
- Melanoma and MAPK Pathways
- Childhood Cancer Survivors' Quality of Life
- Agronomic Practices and Intercropping Systems
- Cardiovascular and exercise physiology
- Microbial Inactivation Methods
- Physical Activity and Health
- Water Quality Monitoring Technologies
University of Manchester
2016-2024
The Christie NHS Foundation Trust
2013-2024
Clatterbridge Cancer Centre NHS Foundation Trust
2023
Fusion Academy
2023
Fusion (United States)
2023
Colorado State University
2020-2022
Food Standards Agency
2006-2020
Colorado School of Public Health
2020
Cancer Research UK Manchester Institute
2016-2019
Manchester Academic Health Science Centre
2016
Although key determinative events of the Rhizobium-legume symbiosis are likely to precede bacterial infection, no plant genes have been identified that expressed strongly prior infection and nodule morphogenesis. A subtractive hybridization-polymerase chain reaction technique was used enrich for induced during early phases R. meliloti-Medicago truncatula symbiosis. One gene so encodes a putative peroxidase protein, which we named Rip1 Rhizobium-induced peroxidase. The accumulation rip1...
Foodborne pathogens, such as Salmonella, may remain in abattoir lairages after cleansing and pose a risk of transfer contamination from one processing day to the next. These organisms be transferred outer surface animals held lairage facilities, skin or hide significant source microbial on red meat carcasses subsequently produced. Sponge samples were taken various sites (n = 556), single-pass sponge side 1,050) at five commercial abattoirs Southwest England tested for presence Salmonella. Of...
Abstract 1. The present systems for cleaning the plastic crates (drawers) used to transport live poultry processing plant are known be inadequate removing microbial contamination. 2. To investigate possible improvements, a mobile experimental rig was constructed and operated in lairage of plant. could simulate conditions commercial utilise freshly emptied from 3. aim study improve by enhancing removal adherent organic material on reducing contamination at least 4 log10 units. 4. Trials...
Virtually supervised, group-based exercise presents an innovative way to expand the reach of exercise-oncology programs and help cancer survivors increase physical activity (PA) connect with other participants. This study examined feasibility, acceptability, preliminary effects a PA program delivered exclusively using videoconferencing software.This used single-group pre-post design. The 8-wk consisted aerobic resistance sessions once per week three behavior change discussion in groups four...
A kinase domain–focused functional genomic screen reveals loss-of-function mutations in a JNK pathway gastric cancer.
Following previous research on improving the cleaning of crates used to transport broiler chickens from farm abattoir, a demonstration project was undertaken investigate improvements in crate washing commercial scale.The soak tank conventional system replaced with high-performance washer fitted high-volume, high-pressure nozzles. The wash water could be heated, and greatly improved filtration ensured that nozzles did not lose performance or become blocked. Visual cleanliness scores microbial...
Abstract The genomic lesions found in malignant tumours exhibit a striking degree of heterogeneity. Many lack known driver mutation, and their genetic basis is unclear. By mapping the somatic mutations identified primary lung adenocarcinomas onto an independent coexpression network derived from normal tissue, we identify critical gene enriched for metastasis-associated genes. While individual genes within this module were rarely mutated, significant accumulation geneset was predictive...
Salmonella contaminatron is of major concern in the production pork As part a UK Food Standards Agency project looking at reducing salmonella contamrnation, survey current processing conditions pig slaughterhouses and review published data identified scalding dehairing systems as likely source contamination during processing.
PURPOSE: The COVID-19 pandemic forced many face-to-face exercise programs for cancer survivors to shut down or transition online delivery. Supervision from a qualified instructor and social support other participants are integral components successful program adherence, but it is challenging create opportunities tangible connection when delivering asynchronously (i.e., without real-time interaction). A group-based delivered online, in real-time, an innovative way help increase physical...
Targeted sequencing of ctDNA is a promising biomarker to inform the prognosis patients (pts) with advanced cancer and guide experimental therapeutics in heterogenous setting phase I trials. Serial monitoring provides an early indication response therapeutics. We performed targeted next-generation 122 serial samples from 34 pts who received medicines within unit. Paired germline was identify somatic-only genomic alterations (GAs). The mean variant allele fraction (mVAF) defined as sum...
<h3>Background:</h3> Sjogren's syndrome (SS) is a chronic autoimmune disorder characterized by inflammation of the lacrimal and salivary glands. Histopathological analysis has previously confirmed increased numbers activated T B cells in patients have levels antibodies directed against SS Antigen A (SSA) or (SSB). cell activating factor (BAFF) plays significant role survival generation autoantibodies. Additionally, BAFF been shown to be elevated circulating blood as well inflamed IL-17...
477 Background: The development of anti-angiogenic therapy produced a change in the treatment metastatic renal cancer (mRCC). There are now range drugs available with sunitinib being most widely used first-line therapy. In United Kingdom, until advent pazopanib it was only such drug routinely funded by NHS. aim this study to audit clinical outcomes patients on routine sunitinib, compare them those obtained trials and analyze different subsets patients. Methods: A database mRCC treated at...
<h3>Introduction</h3> Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare condition characterised by generalised proliferation of cells within the respiratory epithelium. Current literature limited, in particular little known its affects on function both at time diagnosis and prospectively, though it recognised to cause small airway obstruction. <h3>Objective</h3> The aim this study was characterise function, baseline also define change over patients with...