A5044681528- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Diabetes Management and Research
- Pancreatic function and diabetes
- Retinal Imaging and Analysis
- Diabetes and associated disorders
- Dementia and Cognitive Impairment Research
- Retinal Development and Disorders
- RNA regulation and disease
- Balance, Gait, and Falls Prevention
- Health, Environment, Cognitive Aging
- Aging, Health, and Disability
- Intraocular Surgery and Lenses
- Cardiovascular and exercise physiology
- Optical Imaging and Spectroscopy Techniques
- Cardiovascular Disease and Adiposity
- Advanced Drug Delivery Systems
- Retinal and Macular Surgery
- Optical Coherence Tomography Applications
- Physical Activity and Health
- Hippo pathway signaling and YAP/TAZ
- Ocular Surface and Contact Lens
- Body Composition Measurement Techniques
- Advanced Glycation End Products research
- Attention Deficit Hyperactivity Disorder
University of Bari Aldo Moro
2019-2022
University of Genoa
1990-2021
University of Perugia
2014
Products from the advanced Maillard reaction, which increase during aging and diabetes, may contribute to development of typical pathology diabetes. These compounds are detectable only by their characteristic fluorescence, few data based on long-term studies available. For this reason, we studied subcutaneous skin collagen fluorescence in 57 nondiabetic (10- 110-wk-old) 74 streptozocin-induced diabetic 22-wk-old) rats. An exponential (r = 0.969, P less than 0.001) collagen-linked (excitation...
Retinal microvasculature assessment at capillary level may potentially aid the evaluation of early microvascular changes due to hypertension. We aimed investigate associations between measures obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A) hypertension, in a southern Italian older population.We performed cross-sectional analysis from population-based study on 731 participants aged 65 years+ subdivided into two groups according presence or absence blood...
Abstract Background Age-related hearing loss (ARHL) and retinal vessel changes have both been associated to neurodegeneration/dementia, suggesting a possible link between these 2 conditions in older age. We aimed determine whether superficial deep vascular density (SVD DVD) of the capillary plexi macular vasculature can be with peripheral ARHL age-related central auditory processing (CAPD). Method analyzed data on 886 participants (65 years+, age range: 65–92 years) cross-sectional...
A trial was conducted to examine the effect of moderate aerobic exercise training (AET) on cardiorespiratory (CR) fitness. Previously sedentary participants, age 60-75 years, were randomly assigned either AET treatment or a control group for 6 months. The consisted walking 40 min three times/week at an intensity that elevated heart rate 65% maximum reserve. performed supervised stretching program times/week. CR fitness assessed before and after treatments during grade-incremented treadmill...
To verify the efficacy to obtain mydriasis and cardiovascular safety of Mydriasert (ophthalmic insert containing tropicamide phenylephrine) in diabetic nondiabetic patients undergoing retinal angiography by comparing it with usually administered eyedrops (tropicamide 1% phenylephrine 10%).This was a prospective randomized study. A total 154 eyes 77 were randomly divided into 2 groups: group 1 consisted 78 eyes, 76 monitored for pupillary dilation, blood pressure, heart rate, possible adverse...
Type-1 diabetes (T1DM) is a chronic metabolic disorder resulting from the autoimmune destruction of β cells. The current standard care requires multiple, daily injections insulin and accurate monitoring blood glucose levels (BGLs); in some cases, this results diminished patient compliance increased risk hypoglycemia. Herein, we engineered hierarchically structured particles comprising poly(lactic-co-glycolic) acid (PLGA) prismatic matrix, with 20 × μm base, encapsulating 200 nm granules....
Purpose To determine the efficacy of timolol 0.1% gel in preventing increased intraocular pressure (IOP) after uncomplicated cataract surgery. Methods In this prospective, double-blinded, randomized study were enrolled 70 patients who underwent surgery with phacoemulsification and lens implantation. After surgery, 25 received a single instillation (group A); 20 0.5% eyedrops B); no treatment C). The IOP was measured before (T0) 5 minutes (T1), 2 hours ± 30 (T2), 4 (T3), 24 180 (T4). Results...
Objective To explore the linear association between inner retinal layers thickness and macular capillary density compared to variations of global cognition evaluated by psychometric measures in a cohort Mediterranean subjects aged 65+ years. Materials methods We performed cross-sectional analysis 574 participants 65 years+ drawn from population-based Southern Italian study. All underwent neurological evaluations, including cognitive screening, Mini-Mental State Examination (MMSE) frontal...
Diabetes is a chronic disease deriving from the insufficient production or utilization of insulin. So far, treatment diabetes relies on daily subcutaneous injection However, this approach suffers poor patient compliance and fluctuations in blood glucose levels that increases risk hypoglycemia, cardiovascular disease, non-healing wounds other comorbidities. In work, delivery system proposed for controlled release insulin regulation glycaemia. Nanoscale granules were synthesized encapsulated...
Abstract Purpose A key player within diabetic retinopathy is the Vascular Endothelial Growth Factor (VEGF) whose expression seems under Protein Kinase C (PKC) control, although no data are available on molecular pathway underlying this process. Our previous in vitro work retinal bovine pericytes (Amadio et al., Pharmacol Res. 57: 60, 2008) described a new cascade involving PKCβ, mRNA‐stabilizing protein HuR and VEGF. We investigated whether operant also vivo altered by diabetes. Methods...
May 5, 2019April 9, 2019Free AccessAngio-OCT micro vascular markers and central auditory disorder as indipendent predictors of cognitive impairment in the Great Age Study population (P1.9-006)Rodolfo Sardone, Giancarlo Sborgia, Marco Piccininni, Petronilla Battista, Alfredo Niro, Gianluigi Giuliani, Pasquale Puzo, … Show All , Angelo Pascale, Alessandra Chiara Griseta, Maria Rosaria Barulli, Cristina Didio, Grasso, Fabio Castellana, Francesco Coppola, Tiziana Lozupone, Roberta Rucco, Madia...