A5011939616- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Nerve injury and regeneration
- Venous Thromboembolism Diagnosis and Management
- Advanced Proteomics Techniques and Applications
- Cardiovascular and Diving-Related Complications
- Central Venous Catheters and Hemodialysis
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Health, Environment, Cognitive Aging
- Nursing Roles and Practices
- Protease and Inhibitor Mechanisms
- Cardiac Fibrosis and Remodeling
- Fusion and Plasma Physics Studies
- Planarian Biology and Electrostimulation
- Neuroscience and Neural Engineering
- Aortic Disease and Treatment Approaches
- Agricultural risk and resilience
- Cardiovascular Effects of Exercise
- Advanced Radiotherapy Techniques
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pain Management and Opioid Use
- Glycogen Storage Diseases and Myoclonus
Vilnius University
2017-2025
Vilnius University Hospital Santariskiu Klinikos
2011-2024
Icahn School of Medicine at Mount Sinai
2023
Cleveland Clinic
2023
New York University
2023
Texas Cardiac Arrhythmia
2021
St David's Medical Center
2021
Massachusetts General Hospital
2021
Hôpital Privé Jacques Cartier
2021
University of Ulsan
2021
Background: The tissue selectivity of pulsed field ablation (PFA) provides safety advantages over radiofrequency in treating atrial fibrillation. One-shot PFA catheters have been shown capable performing pulmonary vein isolation, but not flexible lesion sets such as linear lesions. A novel lattice-tip catheter with a compressible 9-mm nitinol tip is able to deliver either focal or lesions, each 2 5 s. Methods: In 3-center, single-arm, first-in-human trial, the 7.5F lattice was used custom...
The inspIRE study (Study for Treatment of Paroxysmal Atrial Fibrillation [PAF] by Pulsed Field Ablation [PFA] System With Irreversible Electroporation [IRE]) evaluated safety and effectiveness a fully integrated biphasic pulsed field ablation (PFA) system with variable-loop circular catheter the treatment drug-refractory paroxysmal atrial fibrillation.Subjects underwent pulmonary vein (PV) isolation PFA system, using at least 12 applications per vein; adenosine/isoproterenol was administered...
Because of its safety, "single-shot" pulsed field ablation (PFA) catheters have been developed for pulmonary vein isolation (PVI). However, most atrial fibrillation (AF) procedures are performed with focal to permit flexibility lesion sets beyond PVI.This study sought determine the safety and efficacy a catheter able toggle between radiofrequency (RFA) or PFA treat paroxysmal persistent AF.In first-in-human study, 9-mm lattice tip was used posteriorly either irrigated RFA (RF/PF) (PF/PF)...
BACKGROUND: We previously presented the safety and early efficacy of inspIRE study (Study for Treatment Paroxysmal Atrial Fibrillation [PAF] by Pulsed-field Ablation [PFA] System With Irreversible Electroporation [IRE]). study’s conclusion, we report outcomes full pivotal cohort, with an additional analysis predictors success. METHODS: InspIRE was a prospective, multicenter, single-arm clinical trial drug-refractory paroxysmal atrial fibrillation. Pulmonary vein isolation performed...
Abstract Aims Pulsed field ablation (PFA) has significant advantages over conventional thermal of atrial fibrillation (AF). This first-in-human, single-arm trial to treat paroxysmal AF (PAF) assessed the efficiency, safety, pulmonary vein isolation (PVI) durability and one-year clinical effectiveness an 8 Fr, large-lattice, conformable single-shot PFA catheter together with a dedicated electroanatomical mapping system. Methods results After rendering PV anatomy, delivered monopolar, biphasic...
Abstract Aims Contact force (CF)–sensing radiofrequency (RF) catheters with an ablation index have shown reproducible outcomes for the treatment of atrial fibrillation (AF) in large multicentre studies. A dual-energy (DE) focal CF catheter to deliver RF and unipolar/biphasic pulsed field (PFA), integrated a three-dimensional (3D) mapping system, can provide operators additional flexibility. The SmartfIRE study assessed safety efficacy this novel technology drug-refractory, symptomatic...
BACKGROUND: During electrophysiological mapping of tachycardias, putative target sites are often only truly confirmed to be vital after observing the effect ablation. This lack specificity potentiates inadvertent ablation innocent cardiac tissue not relevant arrhythmia. But if myocardial excitability could transiently suppressed at critical regions, their suitability as targets conclusively determined before delivering tissue-destructive lesions. We studied whether reversible pulsed electric...
This study sought to evaluate the safety and acute performance of lattice tip for treatment atrial flutter fibrillation (AF). A novel catheter using an expandable structure with a wide thermal footprint incorporating multiple surface thermocouples/mini-electrodes has been designed high-resolution mapping high-current, temperature-controlled radiofrequency ablation (RFA). Patients typical right or AF were prospectively enrolled in single-arm at 3 centers. underwent cavotricuspid isthmus (CTI)...
Omny-IRE (A Study For Treatment of Paroxysmal Atrial Fibrillation [PAF] With the OMNYPULSE Catheter and TRUPULSE Generator; NCT05971693) evaluated safety effectiveness a novel large-tip focal, multielectrode, contact force-sensing, pulsed field ablation catheter with electroanatomic mapping integration. This study sought to assess 3-month platform for treating symptomatic paroxysmal atrial fibrillation. Pulmonary vein isolation (PVI) was performed using Platform. Primary...
This study was designed to evaluate lesion durability on invasive electrophysiologic remapping.The lattice-tip catheter generates a large thermal footprint during temperature-controlled irrigated radiofrequency ablation. In first-in-human study, this performed rapid point-by-point pulmonary vein isolation (PVI) and other linear atrial ablations.In prospective 3-center single-arm paroxysmal or persistent fibrillation patients underwent PVI and, as needed, ablation at the cavotricuspid isthmus...
Subthreshold electrical stimulation (SES) has been shown to induce an improvement of angiogenesis in ischemic and nonischemic skeletal muscles, mediated by increased VEGF expression. plays a key role physiological pathological angiogenesis. Cardiomyocytes possess the ability synthesize secrete VEGF. Thus, we thought investigate effect SES on regulation cultured neonatal rat ventricular myocytes (NRVMs), aim reveal new techniques for therapeutic heart disease. Cell cultures NRVMs were...
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Abstract Background/Introduction The inspIRE clinical trial was designed to assess the safety and efficacy of a fully integrated biphasic pulsed field ablation (PFA) system comprised multi-channel generator, variable decapolar irrigated loop circular catheter, mapping (Figure A) for treatment paroxysmal atrial fibrillation (PAF). Purpose Using this novel PFA in multicentre trial, we present initial feasibility electrical pulmonary vein isolation (PVI), procedural performance, acute results....
Therapeutic hypothermia is method used to improve the neurological status of patients who are at risk ischaemia after myocardial infarction. We report a case 28-year-old woman suffered acute infarction complicated by ventricular fibrillation. The patient was successfully resuscitated. Invasive and non-invasive medical treatment applied including therapeutic hypothermia. Success achieved due adequate public reaction, fast transportation, blood vessel revascularization application discharged...