A5065259885- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Hemoglobinopathies and Related Disorders
- Bone health and treatments
- Kruppel-like factors research
- Cardiac pacing and defibrillation studies
- Bone Tissue Engineering Materials
- Pregnancy and preeclampsia studies
- Bone and Joint Diseases
- Iron Metabolism and Disorders
- Mesenchymal stem cell research
Medtronic (United States)
2023-2025
Georgia Institute of Technology
2018-2021
The Wallace H. Coulter Department of Biomedical Engineering
2018-2021
Freedom from atrial arrhythmia (AA) recurrence ≥30 seconds after pulsed field ablation (PFA) in patients with fibrillation (AF) was reported PULSED AF (Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF; ClinialTrials.gov Identifier: NCT04198701). AA burden may be a more clinically meaningful endpoint.The purpose of this study determine the influence monitoring strategies on detection association quality life (QoL) health care utilization (HCU) PFA.Patients underwent...
Abstract Background and aims Early rhythm-control therapy in atrial fibrillation (AF) results higher freedom from arrhythmia (AA) recurrence improved cardiovascular outcomes. The optimal timing of Cryoballoon ablation (CBA) is unknown. Methods We evaluated AA procedure-related complications early vs. late CBA (≤12 >12 months diagnosis) patients enrolled the prospective Cryo Global Registry (121 centers 37 countries, NCT02752737). Results A total 3447 subjects were followed through 12...
Abstract Background Limited information is available on the safety and efficacy of cryoballoon ablation (CBA) in elderly patients with atrial fibrillation (AF). Moreover, global utilization CBA this population (≥ 80 years old) has not been reported. This study’s objectives were to determine use, efficacy, treat octogenarians suffering from AF. Methods In sub-analysis Cryo Global Registry, 12-month outcomes treating AF via compared < old. Efficacy was evaluated as time a ≥ 30 s arrhythmia...
Objective: Sickle cell anemia (SCA) causes chronic inflammation and multiorgan damage. Less understood are the arterial complications, most evident by increased strokes among children. Proteolytic mechanisms, biomechanical consequences, pharmaceutical inhibitory strategies were studied in a mouse model to provide platform for mechanistic intervention studies of large artery damage due sickle disease. Approach Results: Townes humanized transgenic SCA was used test hypothesis that elastic...
Sickle cell disease (SCD) is the most common hereditary blood disorder in United States. SCD frequently associated with osteonecrosis, osteoporosis, osteopenia, and other bone-related complications such as vaso-occlusive pain, ischemic damage, osteomyelitis, bone marrow hyperplasia known sickle (SBD). Previous SBD models have failed to distinguish age- sex-specific characteristics of morphometry. In this study, we use Townes mouse model assess pathophysiological both trait. Changes...
Atrial fibrillation (AF), the most common atrial arrhythmia (AA), is an increasing healthcare burden in Korea. The objective of this sub-analysis Cryo Global Registry was to evaluate long-term efficacy, symptom burden, quality life (QoL), and utilization outcomes factors associated with AA recurrence Korean patients treated cryoballoon ablation (CBA).
Pulsed field ablation (PFA), a novel treatment for atrial fibrillation (AF), has yet to be evaluated in Japanese cohort.
Sickle cell disease (SCD) is the most common inherited blood disorder, affecting 100,000 people domestically, and an additional 300,000 babies with SCD are born globally each year. Children sickle anemia have increased stroke risk, but mechanisms underlying arterial vasculopathy not well defined. Previously, we shown that adhesion of peripheral mononuclear cells (PBMCs) from to human aortic endothelial (ECs) significantly active cathepsin K V enzymes compared wildtype PBMCs suggesting...