A5012038249- Nanoparticle-Based Drug Delivery
- Quantum Dots Synthesis And Properties
- Iron oxide chemistry and applications
- Characterization and Applications of Magnetic Nanoparticles
- Multiferroics and related materials
- Lanthanide and Transition Metal Complexes
- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Magnetic and transport properties of perovskites and related materials
- Thermochemical Biomass Conversion Processes
- Catalysis and Hydrodesulfurization Studies
- Advanced Nanomaterials in Catalysis
- Magnetic Properties and Synthesis of Ferrites
- Advanced Condensed Matter Physics
- Advanced NMR Techniques and Applications
- Blood properties and coagulation
- Electrospun Nanofibers in Biomedical Applications
- Chalcogenide Semiconductor Thin Films
- Inhalation and Respiratory Drug Delivery
- Graphene and Nanomaterials Applications
- Advanced MRI Techniques and Applications
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- Phosphorus and nutrient management
Center for Devices and Radiological Health
2020-2023
United States Food and Drug Administration
2020-2023
Office of Science
2020-2023
University of Puerto Rico System
2015-2022
University of Puerto Rico at Río Piedras
2018
Dopamine (DA) is one of the most important catecholamine neurotransmitters human central nervous system, and involved in many behavioral responses brain functions. Below normal DA levels biological fluids can lead to different neurodegenerative conditions. For excess levels, a failure energy metabolism indicated. In this study, facile room-temperature phosphorescence sensor developed detect based on l-cysteine capped Mn doped ZnS quantum dots (l-cys ZnS:Mn QDs). The QDs display prominent...
Superparamagnetic iron oxide nanoparticles (SPIONs, ~11-nm cores) were PEGylated without anchoring groups and studied as efficient MRI T 2 contrast agents (CAs). The ether group of PEG is efficiently directly linked to the positively charged surface SPIONs, mediated through a dipole-cation covalent interaction. Anchor-free PEG-SPIONs exhibit spin-spin relaxivity 123 ± 6 mM−1s−1, which higher than those anchored with intermediate biomolecules, nanoworms, or Feridex. They do not induce toxic...
Nanoparticle-based cancer theranostic agents generally suffer of poor dispersability in biological media, re-agglomeration over time, and toxicity concerns. To address these challenges, we developed a nanocomposite consisting chemically-reduced graphene oxide combined with manganese-doped zinc sulfide quantum dots functionalized folic acid (FA-rGO/ZnS:Mn). We studied the dispersion stability, Doxorubicin (DOX) loading release efficiency, target specificity, internalization, biocompatibility...
Abstract Ultrasmall superparamagnetic iron oxide nanoparticles (USPION) possess reactive surfaces, are metabolized and exhibit unique magnetic properties. These properties desirable for designing novel theranostic biomedical products; however, toxicity mechanisms of USPION not completely elucidated. The goal this study was to investigate cell interactions (uptake cytotoxicity) using human coronary artery endothelial cells as a vascular model. Polyvinylpirrolidone‐coated were characterized:...
We report a comprehensive quantitative study of the production refined bio-crudes via controlled hydrothermal liquefaction (HTL) process using Ulva fasciata macroalgae (UFMA) as biomass and ultrananocrystalline Fe3O4 (UNCFO) catalyst. X-ray diffraction electron microscopy were applied to elucidate formation high-quality nanocatalysts. Gas chromatography-mass spectroscopy (GC-MS) CHNS analyses showed that bio-crude yield carbon/oxygen ratios increase amount UNCFO increases, reaching peak...
We report here the versatility of Mn-doped ZnS quantum dots (ZnS:Mn QDs) synthesized in aqueous medium for generating reactive oxygen species and detecting cells. Our experiments provide evidence leading to elimination Cd-based cores CdSe/ZnS systems by substitution ZnS. Advanced electron microscopy, X-ray diffraction, optical spectroscopy were applied elucidate formation, morphology, dispersion products. study first time ability ZnS:Mn QDs act as immobilizing agents Tyrosinase (Tyr) enzyme....
Conventional T1- or T2-weighted single mode contrast-enhanced magnetic resonance imaging (MRI) may produce false results. Thereby, there is a need to develop dual contrast agents, and T2-weighted, for more accurate MRI imaging. The agents should possess high (MR) relaxivities, targeted tumor linking, minimum recognition by the immune system. We have developed nitrodopamine-PEG grafted core truncated cubic iron oxide nanoparticles (ND-PEG-tNCIOs) capable of producing marked contrasts in with...
Abstract Ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) have been investigated for biomedical applications, including novel contrast agents, magnetic tracers tumor imaging, targeted drug delivery vehicles, and magneto-mechanical actuators hyperthermia thrombolysis. Despite significant progress, recent clinical reports raised concerns regarding USPION safety related to endothelial cell dysfunction; however, there is limited information on factors contributing these responses....
Abstract The engineering of materials with controlled magnetic properties by means other than a field is great interest in nanotechnology. In this study, we report engineered graphene oxide (MGO) the nanocomposite form iron nanoparticles (IO)-graphene (GO) tunable core magnetism and resonance transverse relaxivity (r 2 ). These are obtained varying IO content on GO. MGO series exhibits r values analogous to those observed conventional single cluster forms different size regimes—motional...
We report the tuning of internal Mn photoluminescence (PL) transition magnetically-ordered Sr-doped lanthanum manganite (LSMO)/Mn-doped zinc sulfide (ZnS:Mn) nanocomposites (NCs) by applying a static magnetic field in range 0–1 T below critical temperature ∼225 K. To do that, we have systematically fabricated LSMO/ZnS:Mn at different concentrations (1:1, 1:3, 1:5 and 1:10 wt%) via straightforward solid-state reaction. X-ray diffraction Raman analyses reveal that both phases coexist with high...
Abstract Biomaterials with nanoscale topography have been increasingly investigated for medical device applications to improve tissue–material interactions. This study assessed the impact of nanoengineered titanium surface domain sizes on early biological responses that can significantly affect tissue Nanostructured coatings distinct roughness were deposited quartz crystal microbalance dissipation (QCM‐D) sensors by physical vapor deposition. Physico‐chemical characterization was conducted...
We investigated the magnetic control of Mn photoluminescence (PL) in iron oxide/l-cysteine-capped zinc sulfide (Fe3O4/l-cys ZnS:Mn) nanocomposites via temperature- and field-dependent PL intensity studies. Fe3O4/l-cys ZnS:Mn was synthesized following a wet chemical deposition route then its physicochemical, morphological, properties were characterized. X-ray diffraction analysis indicates formation semiconducting composite material with coexisting phases high crystalline quality purity....
Surface functionalization of nanoparticles (NPs) may alter their biological interactions such as uptake by alveolar macrophages (AMs).Pulmonary delivery gold NPs (Au NPs) has theranostic potential due to optoelectronic properties, minimal alveoli blood translocation, and possibility specific cell targeting.Here, we examined whether coating Au with transferrin alters protein corona, macrophages, pulmonary translocation.Methods: Rats were intratracheally instilled transferrin-coated (Tf-Au or...
XRD patterns of bare Fe3O4 nanoparticles (SPION), PEGylated (PEG-SPION) and pure PEG powder. Figure S2. (a-e) Bright field HRTEM images PEG-SPION showing cores fully coated with PEG. S3. Zeta potential measurements the isoelectric point (IEP) SPION stabilized (3350). S4. DLS dispersed in deionized water. S5. A proposed mechanism dipole cationic binding ether group to surface hydration process for aqueous dispersibility. (DOCX 71194 kb)