A5032307321- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Virus-based gene therapy research
- Mitochondrial Function and Pathology
- interferon and immune responses
- Neuroscience and Neural Engineering
- Herpesvirus Infections and Treatments
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Cardiac electrophysiology and arrhythmias
- Retinal Development and Disorders
McGovern Institute for Brain Research
2024
Massachusetts Institute of Technology
2024
Broad Institute
2021-2024
Ottawa Hospital Research Institute
2023
Ottawa Hospital
2023
University of Tennessee at Chattanooga
2020
Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer immunotherapies. In addition to their oncolytic capacity immunogenic influence, they can be readily engineered express multiple large transgenes. However, the integration of payloads into poxvirus genomes by traditional recombination-based approaches highly inefficient, time-consuming cumbersome. Herein, we describe a simple, cost-effective approach rapidly generate purify vector with By utilizing...
Thalamocortical (TC) circuits are essential for sensory information processing. Clinical and preclinical studies of autism spectrum disorders (ASDs) have highlighted abnormal thalamic development TC circuit dysfunction. However, mechanistic understanding how dysfunction contributes to behavioral abnormalities in ASDs is limited. Here, our study on a Shank3 mouse model ASD reveals neuron hyperexcitability with excessive burst firing temporal mismatch relationship slow cortical rhythms during...