A5101992469- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Legume Nitrogen Fixing Symbiosis
- Soybean genetics and cultivation
- Sirtuins and Resveratrol in Medicine
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Plant and Fungal Interactions Research
- Nuts composition and effects
- Genetics and Plant Breeding
- Genetic diversity and population structure
- Cancer Mechanisms and Therapy
- Plant pathogens and resistance mechanisms
- CAR-T cell therapy research
- Animal Genetics and Reproduction
- Autophagy in Disease and Therapy
- High Altitude and Hypoxia
- SARS-CoV-2 and COVID-19 Research
- Adipose Tissue and Metabolism
- Proteoglycans and glycosaminoglycans research
- Mathematical Inequalities and Applications
- Rangeland Management and Livestock Ecology
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
Dongguan People’s Hospital
2025
Chongqing University of Posts and Telecommunications
2024-2025
Guangzhou University of Chinese Medicine
2025
Chinese Academy of Agricultural Sciences
2013-2024
Tangshan Gongren Hospital
2024
Ottawa Hospital Research Institute
2017-2023
Institute of Animal Sciences
2011-2023
Ministry of Agriculture and Rural Affairs
2020-2023
Ottawa Hospital
2013-2023
Jinan University
2023
Autologous chimeric antigen receptor T (CAR-T) cell therapy is an effective treatment for relapsed/refractory acute lymphoblastic leukemia (r/r ALL). However, certain characteristics of autologous CAR-T cells can delay availability. Relapse caused by escape after single-targeted another issue. Therefore, we aim to develop CRISPR-edited universal off-the-shelf CD19/CD22 dual-targeted as a novel r/r ALL.In this open-label dose-escalation phase I study, CD19/CD22-targeting (CTA101) with...
The Tibetan cashmere goat (Capra hircus), one of the most ancient breeds in China, has historically been a critical source meat and production for local farmers. To adapt to high-altitude area, extremely harsh climate, hypoxic environment that lives in, this developed distinct phenotypic traits compared lowland breeds. However, genetic components underlying adaptation remain largely unknown.
Type 2 diabetes, hepatic steatosis, and gut dysbiosis are pathophysiological consequences of obesity. Sirtuin (SIRT)-1 is a protein deacetylase implicated in the regulation metabolic activity. We set out to determine whether catalytic activity SIRT1 plays role development syndrome, distribution microbiota. challenged with high-fat diet (HFD) strain mice homozygous for Sirt1 allele carrying point mutation that ablates SIRT1. When compared wild-type animals, lacking rapidly accumulated...
Abstract Recent advances in cancer therapeutics clearly demonstrate the need for innovative multiplex therapies that attack tumour on multiple fronts. Oncolytic or “cancer-killing” viruses (OVs) represent up-and-coming multi-mechanistic immunotherapeutic drugs treatment of cancer. In this study, we perform an in-vitro screen based virus-encoded artificial microRNAs (amiRNAs) and find a unique amiRNA, herein termed amiR-4, confers replicative advantage to VSVΔ51 OV platform. Target validation...
Prostatic intraepithelial neoplasia is a precursor to prostate cancer. Herein, deletion of the NAD(+)-dependent histone deacetylase Sirt1 induced histological features prostatic at 7 months age; these were associated with increased cell proliferation and enhanced mitophagy. In human cancer, lower expression in luminal epithelium was poor prognosis. Genetic mitochondrial superoxide dismutase 2 (Sod2) acetylation lysine residue 68, thereby enhancing reactive oxygen species (ROS) production...
Fat tail is a unique trait in sheep acquired during domestication. Several genomic analyses have been conducted breeds from limited geographic origins to identify the genetic factors underlying this trait. Nevertheless, these studies obtained different candidates. The results of regional were easily biased by breed structures.To minimize bias and distinguish true candidates, we used an extended data set 968 representing 18 fat-tailed 14 thin-tailed around world, integrated two statistical...
Abstract The Sirtuin family of proteins (SIRT) encode a group evolutionarily conserved, NAD-dependent histone deacetylases, involved in many biological pathways. SIRT1, the human homologue yeast Silent Information Regulator 2 (Sir2) gene, deacetylates histones, p300, p53, and androgen receptor. Autophagy is required for degradation damaged organelles long-lived proteins, as well development glands such breast prostate. Herein, homozygous deletion Sirt1 gene mice resulted prostatic...
Abstract Sheep has successfully adapted to the extreme high-altitude Himalayan region. To identify genes underlying such adaptation, we genotyped genome-wide single nucleotide polymorphisms (SNPs) of four major sheep breeds living at different altitudes in Nepal and downloaded SNP array data from additional Asian Middle East breeds. Using a d i value-based genomic comparison between eight lowland breeds, discovered most differentiated variants locus FGF-7 ( Keratinocyte growth factor-7 ),...
Body size, one of the most important quantitative traits under evolutionary scrutiny, varies considerably among species and populations within species. Revealing genetic basis underlying this variation is very important, particularly in humans where there a close relationship with diseases domestic animals as selective patterns are associated improvements production traits. The Debao pony horse breed small body size that unique to China; however, it unknown whether size-related candidate...
Summary Goat farming in Pakistan depends on indigenous breeds that have adapted to specific agro‐ecological conditions. has a rich resource of goat breeds, and the genetic diversity these is largely unknown. In this study, population structure were characterized from seven using 50K SNP chip. The analysis showed Bugi toori goats highest inbreeding level, consistent with linkage disequilibrium, lowest long run heterozygosity segments. This indicates breed should be prioritized future...
Pod dehiscence (shattering) is the main cause of serious yield loss during soybean mechanical harvesting process. A better understanding genetic architecture and molecular mechanisms pod great significance for breeding. In this study, genome-wide association analysis (GWAS) with NJAU 355K SoySNP array was performed to detect single nucleotide polymorphisms (SNPs) associated in an panel containing 211 accessions across five environments. total 163 SNPs were identified as significantly...
Colorectal cancer is the third most diagnosed and second leading cause of mortality worldwide, highlighting an urgent need for new therapeutic options combination strategies patients. The orchestration potent T cell responses against human cancers necessary effective antitumour immunity. However, regression a limited number has been induced by immune checkpoint inhibitors, engagers (TCEs) and/or oncolytic viruses. Although one TCE FDA-approved treatment hematological malignancies, many...
Summary The SirT1 gene encodes a protein deacetylase that acts on number of nuclear substrates. p53 was identified as substrate whose transcriptional activity reported to be negatively regulated by SirT1‐dependent deacetylation. We set out determine whether developmental defects and perinatal lethality observed in SirT1‐null mice were caused hyperactivity creating deficient for both p53. Animals null proteins smaller than normal at birth, had eyelid opening died during the late prenatal...
Abstract MicroRNAs (miRNAs) are evolutionarily conserved, small, non-coding RNAs that have emerged as key regulators of myogenesis. Here, we examined the miRNA expression profiles developing sheep skeletal muscle using a deep sequencing approach. We detected 2,396 miRNAs in tissues. Of these, miR-192 was found to be up-regulated prenatal muscle, but down-regulated postnatally. MiR-192 also decreased during myogenic differentiation satellite cells (SCs). overexpression significantly...
Famous Chinese strong-flavored liquor (CSFL) is brewed by microbial consortia in a special fermentation pit (FT). However, the process was not fully understood owing to complicate community structure and metabolism. In this study, process-related dynamics of communities main flavor compounds during 70-day were investigated simulated system. A three-phase model proposed characterize CSFL fermentation. (i) early period (1–23 days), glucose produced from macromolecular carbohydrates (e.g.,...
The growth of cashmere exhibits a seasonal pattern arising from photoperiod change. However, the underlying molecular mechanism remains unclear. We profiled skin transcriptome six goats at seven time points during hair follicle cycling via RNA-seq. comprised three exposed to natural and shortened photoperiod. During cycle transition, 1713 genes showed differential expression, 332 periodic expression. Moreover, short induced enter anagen early, 246 overlapped with genes. Among these key...
To help multinationals meet consumer needs in the People’s Republic of China (PRC), this paper describes culture, social forces, marketing mix and behavior for durables nondurables. Cameras, cosmetics, fast food restaurants soft drinks are earlier lifecycle stages PRC than USA, represent a price/durability continuum. A joint effort USA/PRC researchers, with about 3,000 responses, shows that product versus price‐focus differentiates price segments, experience age segments. Results suggest...