Abstract BACKGROUND African‐American women face an increased risk of early‐onset breast carcinoma compared to white American women, and has been reported be particularly aggressive in premenopausal women. METHODS Surveillance, Epidemiology, End Results Program data were analyzed for 507 1378 patients from Detroit diagnosed with under the age 40 between 1990 1999. RESULTS The proportion situ disease detected 1995 1999 nearly doubled 1990‐1994 interval (11.3% 6.4%) but was consistently lower...

Background. Impaired control of foot trajectory during the swing phase gait is hypothesized to increase risk slipping or tripping. Before assessing predictive validity measures with respect incidence falls, it necessary establish their reliability. The purpose this study assess within- and between-session reliability traditional temporal-distance in healthy elderly women gait. Methods. Sixteen healthy, (ages 65–79 years) completed six sets five trials each natural fast cadence a 3.5-hour...

Purpose: Patients with chronic obstructive pulmonary disease (COPD) have been shown to benefit from triple therapy commonly delivered by multiple-inhaler (MITT); however, the complexity of MITT regimens may decrease patient adherence. Fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI), a once-daily single-inhaler (SITT), became available in United States (US) 2017, but real-world data comparing outcomes for SITT versus are currently limited. This study compared among patients COPD...

To examine the impact of initiating fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) in a single device on chronic obstructive pulmonary disease (COPD) exacerbations, COPD exacerbation-related costs, and all-cause COPD-related healthcare resource utilization (HCRU) costs patients with COPD.Retrospective database analysis aged ≥40 years who initiated FF/UMEC/VI between September 1, 2017, December 31, 2018 (index date: first pharmacy claim for FF/UMEC/VI), following evidence...

Abstract BACKGROUND Aggressive treatment of early stage prostate carcinoma (PC) is limited primarily to two modalities: radical prostatectomy (RP) and external beam radiation therapy (RT). The authors conducted a population‐based study Detroit area men with localized PC determine the outcome bowel, urinary, sexual function after aggressive treatment. METHODS Men were identified through Metropolitan Cancer Surveillance System, member National Institute Surveillance, Epidemiology, End Results...

Non-small cell lung cancer (NSCLC) is the most common form of in United States. Immunotherapies and cytotoxic chemotherapies used to treat advanced NSCLC carry a substantial risk adverse events (AEs), but real-world data on incidence costs associated with unique AE profiles these treatments are sparse.To examine among patients initiating non-driver mutation-targeted first-line therapy for metastatic (mNSCLC) clinical practice.This was retrospective administrative claims study conducted...

e13592 Background: To date, there has been a paucity of information in the literature describing epidemiology mCRPC within prostate cancer population. We present real-world data study characteristics and mortality patients with an administrative claims database insured population United States. Methods: In ≈18,000,000 covered lives, adult male were included if they had ≥1 claim for (ICD-9: 185 or 233.4; ICD-10: C61 D075), underwent pharmacologic surgical castration, code metastatic disease...

Ovarian cancer (OC) is one of the leading causes mortality among women in United States. With approval first-line maintenance therapies, patients with OC experienced prolonged progression-free survival. While literature addresses some costs associated OC, further research needed on progression that are potentially deferred or prevented by early maintenance. The objective this study was to capture health care resource utilization and advanced who never received poly(ADP ribose) polymerase...

Acute and chronic graft-versus-host disease (aGVHD/cGVHD) are serious conditions occurring after allogeneic hematopoietic cell transplantation (HCT). Steroids the most common first-line therapy; however, they frequently associated with numerous morbid complications. To describe healthcare resource utilization (HCRU) costs of steroid-related complications in patients receiving systemic steroids for GVHD. This retrospective study used medical pharmacy claims from Optum Research database....

<i>Background:</i> Although urinary incontinence is a challenge and burden to older patients, many clinicians fail query patients about symptoms or, even when aware of problem, diagnose the underlying cause or recommend treatment We wanted compare approaches physician assistants, nurse practitioners, family physicians detection, diagnosis, initial management in adults seen rural primary care practices. <i>Methods:</i> One male 2 female simulated portrayed otherwise healthy with incontinence,...

e20655 Background: Chemotherapy and immunotherapy (IO) are associated with increased overall survival in patients mNSCLC, yet real-world data on AE-associated healthcare utilization sparse. This study assessed incidence AEs among initiating first-line treatment for mNSCLC IO, IO chemotherapy (IC), or alone (CH). Methods: Data were claims from commercial Medicare Advantage (Jan 2008-Feb 2018). Inclusion criteria health plan enrollment ≥6 months pre- (baseline) ≥1 month post-index date;...

BACKGROUND: The American Association for the Study of Liver Diseases (AASLD) and Infectious Society America (IDSA) recommended in May 2019 that patients with hepatitis C virus (HCV) could be assessed treatment initiation a simplified algorithm. This approach uses standard blood fibrosis tests, rather than genotype testing, to guide pan-genotypic direct-acting antiviral agents (DAAs) sofosbuvir/velpatasvir (SOF/VEL) or glecaprevir/pibrentasvir (GLE/PIB) treatment. OBJECTIVE: To compare health...

e19319 Background: Prostate cancer (PC) is the most common among men in United States. Once disease progresses to mCRPC, initial castration modalities may not be sufficient. This real-world data study describes treatment patterns and pharmacy costs of US-insured patients with mCRPC. Methods: Adult males an administrative claims database who had ≥1 claim for PC (ICD-9: 185 or 233.4; ICD-10: C61 D075), undergone pharmacologic surgical castration, a code metastatic during identification period...

Limited research is available on the real-world experiences of patients with dementia Lewy bodies (DLB). This study evaluated clinical events, healthcare utilization, and costs DLB vs other types psychosis (ODP). Study included commercial Medicare Advantage Part D enrollees aged ≥40 years evidence ODP from 6/01/2015‒5/31/2019. Compared ODP, more had events including anticholinergic effects, neurologic cognitive decline. Patients used resources greater dementia-related office outpatient...

Aim: Androgen receptor pathway inhibitors (ARPIs) prolong metastasis-free survival and overall in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC). This study aimed to evaluate real-world treatment patterns, utilization outcomes nmCRPC. Patients & methods: retrospective cohort used Optum database electronic health records of nmCRPC from 1 January 2007 31 December 2020 the US. Results: Of 1955 patients, >80% received androgen-deprivation therapy (ADT) alone or ADT +...

Clinical trials have shown that maintenance therapy for ovarian can­cer after response to platinum chemotherapy prolongs progression-free survival. We sought examine the real-world use of various therapies recurrent cancer. Methods. conducted a retrospective cohort study US patients ≥18 years old with cancer utilizing diagnoses from claims data. Patients were identified using two-step algorithm and if they had ≥2 ≥30 days apart between July 1, 2010, December 31, 2019, subsequent systemic...

"HSR20-104: Treatment Patterns and Time Trends for Intrahepatic Cholangiocarcinoma (iCCA) Patients: A Real-World Retrospective Claims Study" published on 20 Mar 2020 by National Comprehensive Cancer Network.

Abstract Background DLB is the second‐most common form of degenerative dementia and it’s unclear whether healthcare costs differ for patients with Alzheimer’s disease. [1],[2]. The differential presentation psychosis among dementias[3] may affect costs. [1] Bostrom F, Jonsson L, Minthon Londos E. Patients Lewy body use more resources than those Int J Geriatr Psychiatry 2007;22(8):713‐719. [2] Zhu CW, Scarmeas N, Stavitsky D, Albert M, Brandt J, Blacker Sano Stern Y. Comparison care between...