A5018297607- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Mathematical Biology Tumor Growth
- Nanoplatforms for cancer theranostics
- Elasticity and Material Modeling
- Salivary Gland Tumors Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Vascular Malformations Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Radiopharmaceutical Chemistry and Applications
- Spinal Dysraphism and Malformations
- Photoacoustic and Ultrasonic Imaging
- Drug Transport and Resistance Mechanisms
- Cleft Lip and Palate Research
- Medical Imaging and Analysis
- Vascular Malformations and Hemangiomas
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- Oral and Maxillofacial Pathology
- Optical Imaging and Spectroscopy Techniques
- Machine Learning in Materials Science
- Meningioma and schwannoma management
- Systemic Lupus Erythematosus Research
- Ultrasound Imaging and Elastography
Mayo Clinic in Florida
2017-2023
Mayo Clinic Hospital
2017-2023
WinnMed
2017-2023
Mayo Clinic in Arizona
2019-2022
Mayo Clinic
2020-2022
State of Illinois
2020
Neurological Surgery
2017-2019
Arizona State University
2017
Five immunocompetent C57BL/6-cBrd/cBrd/Cr (albino C57BL/6) mice were injected with GL261-luc2 cells, a cell line sharing characteristics of human glioblastoma multiforme (GBM). The imaged using magnetic resonance (MR) at five separate time points to characterize growth and development the tumor. After 25 days, final tumor volumes varied from 12 mm3 62 mm3, even though inoculated same under carefully controlled conditions. We generated hypotheses explore large variances in size tested them...
DSC-MR imaging using preload, intermediate (60°) flip angle and postprocessing leakage correction has gained traction as a standard methodology. Simulations suggest that with = 30° no preload yields relative CBV practically equivalent to the reference standard. This study tested this hypothesis in vivo.Eighty-four patients brain lesions were enrolled 3-institution study. Forty-three satisfied inclusion criteria. (3T, single-dose gadobutrol, gradient recalled-echo-EPI, TE 20-35 ms, TR...
<h3>BACKGROUND AND PURPOSE:</h3> MR imaging–based modeling of tumor cell density can substantially improve targeted treatment glioblastoma. Unfortunately, interpatient variability limits the predictive ability many approaches. We present a transfer learning method that generates individualized patient models, grounded in wealth population data, while also detecting and adjusting for variabilities based on each patient9s own histologic data. <h3>MATERIALS METHODS:</h3> recruited patients with...
Objectives To assess the outcomes of abdominal dermal‐fat grafting following superficial and total parotidectomy. Methods A retrospective chart review parotidectomy patients was performed. Patients were divided into four groups based on surgical extent status: (SP), with (SPg), (TP), (TPg). Complication rates operative times then compared between surgically matched (SP vs. SPg, TP TPg). Complications included graft necrosis, gustatory sweating, first‐bite syndrome, infection, hematoma,...
Objectives/Hypothesis Use validated eye‐tracking technology to objectively measure 1) the attentional distraction of facial contour defects after superficial and total parotidectomy 2) changes in with abdominal dermal fat graft reconstruction. Methods Standardized frontal oblique images 16 patients who had undergone or without reconstruction; four normal controls were obtained. One hundred casual observers recruited view these images, gaze data collected using a Tobii Pro system. Gaze...
Brain cancers pose a novel set of difficulties due to the limited accessibility human brain tumor tissue. For this reason, clinical decision-making relies heavily on MR imaging interpretation, yet mapping between MRI features and underlying biology remains ambiguous. Standard (clinical) tissue sampling fails capture full heterogeneity disease. Biopsies are required obtain pathological diagnosis predominantly taken from core, which often has different traits surrounding invasive that...
This paper proposes a computationally efficient method for estimating the topology of manifold data in context medical applications. Betti numbers computed with persistent homology tools can be more useful hepatic decompensation prediction patients Primary Sclerosing Cholangitis. We propose an alternative that uses to estimate status. The results show proposed methodology is capable distinguishing between and non-hepatic discovered using number-based machine-learning approach, we make...
Abstract We present the case of a 56-yr-old right-handed male, after informed consent was obtained, who presented with acute confusion and agitation, on background remote history an uncomplicated resection left parietal grade 2 glioma. Imaging revealed large, right temporal intracerebral hemorrhage (ICH). Standard vascular workup for cause ICH included catheter angiography. No direct revealed; however, high parasagittal dural arteriovenous fistula (DAVF) cortical venous reflux noted close to...
The practice of neurosurgery involves complex and high-precision surgery. To avoid unwanted sequelae, safe manipulation minimal resection brain tissue are paramount importance. Technological innovations like stereotactic image-guided surgery have helped neurosurgeons more precisely define their excision sites by incorporating the function entry lesion locations as well pathology itself. However, certain problems with current technology persist. One limitation is shift resulting from surgical...
Abstract Seizures are common presenting symptoms of primary brain tumors. Mechanisms epileptogenesis still unknown and believed to be multifactorial. Previous studies have indicated correlation seizure with tumor location. Recent investigations our group shown image-based parameters sex-specific implications for patient outcome. In this retrospective study, we examined the association location probability risk in male female glioma patients.
Abstract Brain cancers pose a novel set of difficulties due to the limited accessibility human brain tumor tissue. For this reason, clinical decision-making relies heavily on MR imaging interpretation, yet mapping between MRI features and underlying biology remains ambiguous. Standard (clinical) tissue sampling fails capture full heterogeneity disease. Biopsies are required obtain pathological diagnosis predominantly taken from core, which often has different traits surrounding invasive that...
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults with a median survival of 14–16 months. Patient sex plays an important role GBM as there difference incidence rates and outcome between males females, which may be attributable to differences genetic makeup physiology. Investigate impact location on outcomes based location, laterality, age, handedness, extent resection. Patients (129 87 females) who received standard-of-care were included. Analyses performed using...
PURPOSE: Despite a growing body of research on the etiology seizures in brain tumor population, it is not yet clear why approximately one third this population presents with seizure. In retrospective study we seek to assess impact location risk seizure among male and female glioma patients, respectively. From our multi-institutional database, selected adult patients contrast-enhancing gliomas (any grade) known seizure-presentation status at initial diagnosis. Tumors were segmented...
Abstract Gliomas are brain tumors characterized by highly variable growth patterns. Magnetic resonance imaging (MRI) is the cornerstone of glioma diagnosis and management planning. However, features on MRI do not directly correlate with tumor cell distribution. Additionally, there evidence that characteristics prognosis sex-dependent. elastography (MRE) an technique allows interrogation tissue stiffness in-vivo has found utility in several cancers. We investigate relationship between...