A5056875537- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Mathematical Biology Tumor Growth
- Alcohol Consumption and Health Effects
- Brain Metastases and Treatment
- Sex and Gender in Healthcare
- Estrogen and related hormone effects
- Meningioma and schwannoma management
- Brain Tumor Detection and Classification
- Cannabis and Cannabinoid Research
- Liver Disease Diagnosis and Treatment
- Cell Image Analysis Techniques
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Complement system in diseases
- Advanced Electron Microscopy Techniques and Applications
- Childhood Cancer Survivors' Quality of Life
- Radiopharmaceutical Chemistry and Applications
- Renal function and acid-base balance
- Renal Diseases and Glomerulopathies
- Circular RNAs in diseases
- Muscle metabolism and nutrition
- Prenatal Substance Exposure Effects
- Pharmacogenetics and Drug Metabolism
- Medical Imaging Techniques and Applications
University of Massachusetts Chan Medical School
2023
Mayo Clinic in Florida
2018-2021
Neurological Surgery
2021
Mayo Clinic Hospital
2018-2020
Mayo Clinic in Arizona
2019
Tennessee Technological University
2002
University of Georgia
1995-2002
Male and female glioblastomas are biologically distinct, improving outcomes may require sex-specific approaches to treatment.
Abstract Background Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance features has not been thoroughly explored for sex differences. Methods Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have sex-specific impact on survival patients (299 males 195 females). Results Among males, tumor (T1Gd) radius was predictor...
Abstract Lacunarity, a quantitative morphological measure of how shapes fill space, and fractal dimension, the complexity pixel arrangement, have shown relationships with outcome across variety cancers. However, application these metrics to glioblastoma (GBM), very aggressive primary brain tumor, has not been fully explored. In this project, we computed lacunarity dimension values for GBM-induced abnormalities on clinically standard magnetic resonance imaging (MRI). our patient cohort (n =...
Background Temozolomide (TMZ) has been the standard-of-care chemotherapy for glioblastoma (GBM) patients more than a decade. Despite this long time in use, significant questions remain regarding how best to optimize TMZ therapy individual patients. Understanding relationship between response and factors such as number of adjuvant cycles, patient age, sex, image–based tumor features, might help predict which GBM would benefit most from TMZ, particularly those whose tumors lack...
Glioblastoma (GBM) is the most aggressive primary brain tumor and can have cystic components, identifiable through magnetic resonance imaging (MRI). Previous studies suggest that cysts occur in 7-23% of GBMs report mixed results regarding their prognostic impact. Using our retrospective cohort 493 patients with first-diagnosis GBM, we carried out an exploratory analysis on this potential link between GBM survival. pretreatment MRIs, manually identified 88 had a significant component at...
Fetal alcohol syndrome (FAS) refers to a pattern of birth defects occurring in subpopulation children born women who consume during pregnancy. The significant medical, social, and economic impact FAS is increasing. Particularly hard‐hit are African‐American native‐American children. Over the past two decades, basic clinical research produced voluminous data on ethanol effects developing organisms. In 1991, Duester Pullarkat proposed that competition with retinol at dehydrogenase (ADH)...
Background Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance features has not been thoroughly explored for sex differences. Methods Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have sex-specific impact on survival patients. Pretreatment images 494 patients (299 males 195 females) were segmented to quantify tumor...
Recovery of acetaldehyde (0-20 microM) or ethanol (0-50 mM) added to blood and subsequently treated with perchloric acid (PCA) was evaluated using head-space gas chromatography compared controls. Using from five dogs, < 100% recovered PCA-treated samples. Mathematical models putative binding mechanisms indicated partitioned simply between supernatant PCA-induced precipitate occupied 1% sites on precipitate; > 62% sites. The mathematical model also is 2500-fold stronger than binding. These...
CNS involvement may be seen at any time point in patients with systemic Non-Hodgkin lymphoma (SNHL).The leptomeninges are the most common site of involvement, however parenchymal metastases up to 1/3 patients.Given potentially disabling nature such lesions, early diagnosis initiation appropriate therapy paramount importance.MRI remains primary tool for initial detection suspected spread lymphoma.Diffusion-weighted imaging is often used employed and response cellular neoplasms.The goal this...
Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor and can have cystic components, identifiable through magnetic resonance imaging (MRI). Previous studies suggest that cysts occur in 7-23% of GBMs report mixed results regarding their prognostic impact. Using our retrospective cohort 493 patients with first-diagnosis GBM, we carried out an exploratory analysis on this potential link between GBM survival. pretreatment MRIs, manually identified 88 had a significant component...
Background One challenge of using even relatively simple pharmacokinetic models is valuation model parameters. Unknown parameter values can be determined by fitting the to measured data. Goals present study were (1) obtain ethanol data from a cohort dogs, (2) propose physiologic model, (3) and perform Monte Carlo simulation determine values. The rationale for particular proposed here was account interrelationship between blood concentration gastrointestinal physiology. Methods To each five...
Abstract Although glioblastoma is a fatal primary brain cancer with short median survival of 15 months, small number patients survive more than 5 years after diagnosis; they are known as extreme survivors (ES). Due to their rarity, very little about what differentiates these outliers from other patients. For the purpose identifying unknown drivers survivorship in glioblastoma, we developed ENDURES consortium (ENvironmental Dynamics Underlying Responsive Extreme Survivors glioblastoma). This...
Abstract Temozolomide (TMZ) has been the standard-of-care chemotherapy for glioblastoma (GBM) patients more than a decade. Despite this long time in use, significant questions remain regarding how best to optimize TMZ therapy individual patients. Understanding relationship between response and factors such as number of adjuvant cycles, patient age, sex, image-based tumor features, might help predict which GBM would benefit most from TMZ, particularly those whose tumors are not MGMT...
Abstract Sex differences in brain tumor related epilepsy (BTE) as an initial symptom of glioma are rarely investigated. being explored with increased interest more recently. Epidemiological studies have generally indicated overall incidence to be slightly higher males than females, but a idiopathic generalized has been seen females some studies. Clinicians regularly face the challenge anti-epileptic drug prescription determination patients newly identified mass and would greatly benefit from...
The goals of the present study were (1) to obtain ethanol pharmacokinetic data from fed dogs, and (2) perform Monte Carlo simulation determine effect food on model parameter values. To a cohort five 1 g per km body weight was administered as gavage 20% w/v solution. Blood samples taken at 0, 10, 20, 30, 40, 60, 80, 100, 120, 180, 240, 360 minutes after dose mixed with anticoagulant stored ice. concentration determined via headspace chromatograph. an used estimate values standard deviations...
Abstract Background : Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance features has not been thoroughly explored for sex differences. Methods Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have sex-specific impact on survival patients (299 males 195 females). Results Among males, tumor (T1Gd) radius was predictor...
PURPOSE: Seizures are frequent symptoms of gliomas. Predicting which patients more likely to seize and in turn require anti-epileptic management has been a challenge. Correctly identifying these could help optimize care minimize side effects. To provide guidance for clinicians, we used machine learning techniques predict seizure presentation this population. We volumetric data pre-treatment MR images (T1Gd T2-FLAIR sequences), patient demographics (age; sex), measurements tumor proliferation...
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults with a median survival of 14–16 months. Patient sex plays an important role GBM as there difference incidence rates and outcome between males females, which may be attributable to differences genetic makeup physiology. Investigate impact location on outcomes based location, laterality, age, handedness, extent resection. Patients (129 87 females) who received standard-of-care were included. Analyses performed using...
MRI-based modeling can help characterize the intratumoral genetic heterogeneity of Glioblastoma (GBM). Yet, published models to date have neglected potential impact sex-differences on accuracy MRI-genetic correlations. Specifically, there is growing awareness that female GBM patients display different genetic/molecular aberrations and phenotypic expression compared male counterparts. In this exploratory study, we compare MRI signal key driver alterations across a cohort patients, using...