A5080561215- Pregnancy and preeclampsia studies
- Global Maternal and Child Health
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Bone and Dental Protein Studies
- Genomic variations and chromosomal abnormalities
- Cancer Treatment and Pharmacology
- Hormonal and reproductive studies
- Genetic Syndromes and Imprinting
- Antioxidant Activity and Oxidative Stress
- Gestational Trophoblastic Disease Studies
- Genomics and Rare Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Ferrocene Chemistry and Applications
- Natural Products and Biological Research
- Click Chemistry and Applications
- Demographic Trends and Gender Preferences
- Gestational Diabetes Research and Management
- Tea Polyphenols and Effects
- Chronic Kidney Disease and Diabetes
- Ion channel regulation and function
- Plant biochemistry and biosynthesis
- Organ Transplantation Techniques and Outcomes
- Protein Tyrosine Phosphatases
Instituto Nacional de Perinatología
2019-2025
Instituto Politécnico Nacional
2014-2023
John Wiley & Sons (United Kingdom)
2019
Hudson Institute
2019
Vall d'Hebron Hospital Universitari
2019
Universidad Nacional Autónoma de México
2009-2011
University of South Florida
1990
Florida College
1990
Breast cancer, due to its high incidence and mortality, is a public health problem worldwide. Current chemotherapy uses non-specific cytotoxic drugs, which inhibit tumor growth but cause significant adverse effects. (−)-Epicatechin (EC) part of large family biomolecules called flavonoids. It widely distributed in the plant kingdom; it can be found green tea, grapes, cocoa. Several studies animals humans have shown that EC induces beneficial effects skeletal muscle cardiovascular system,...
(-)-Epicatechin (EC) is a flavanol that has shown numerous biological effects such as: decrease risk of cardiovascular dysfunction, metabolism regulation, skeletal muscle (SkM) performance improvement and SkM cells differentiation induction, among others. The described EC acceptor/receptor molecules do not explain the EC's effect on SkM. We hypothesize pregnane X receptor (PXR) can fulfill those characteristics, based structural similitude between steroidal backbone PXR activation leads to...
Neonatal hypotonia is a relatively common cause of consultation in daily pediatric practice. It part the clinical presentation large group heterogeneous diseases, many which have an important and classifiable genetic background. Identification specific disorder can help optimize management treatment patient inform counseling for family, therefore input from geneticists critical at earliest stages medical management. Here we present 30 patients with unknown etiology referred by...
Two siblings from a Mexican family who carried lethal Raine syndrome are presented. A newborn term male (case 1) and his 21 gestational week brother 2), with similar osteosclerotic pattern: generalized osteosclerosis, which is more evident in facial bones cranial base. Prenatal findings at weeks histopathological features for case 2 described. novel combination of biallelic FAM20C pathogenic variants were detected, maternal cytosine duplication position 456 paternal deletion 474 exon 1,...
The main aim of this work was to analyse the potential tumour growth inhibition effects (-)-epicatechin (EC). Triple-negative breast cancer (TNBC) is an invasive form characterized by absence progesterone receptor, estrogen receptor and human epidermal factor 2. Doxorubicin (DOX) widely used for its anti-tumour activity. EC belongs flavanol subfamily a candidate molecule adjuvant treatment due antiproliferative activities.
Turner syndrome (TS) is one of the most common sexual chromosome abnormalities and clearly associated with an increased risk autoimmune diseases, particularly thyroid disease coeliac (CD). Single-nucleotide polymorphism analyses have been shown to provide correlative evidence that specific genes are disease. Our aim was study functional polymorphic variants PTPN22 ZFAT in relation those MYO9B CD. A cross-sectional comparative analysis performed on Mexican mestizo patients TS age-matched...
Abstract Objective Rhabdomyomas are the most common type of prenatal cardiac tumors. When isolated, 50% to 70% related tuberous sclerosis complex (TSC). The aim this study was reinforce importance additional clinical data in patients with heart Methods From 2010 2017, 10 prenatally detected tumors were referred Genetics Department, and a complete family history taken. Postnatal echocardiographic full evaluation completed. Next generation sequencing (NGS) TSC1 TSC2 genes performed. Results...
Approximately 10-15 % of all clinically recognized pregnancies end in miscarriage, the majority them occur during first trimester, underlying cause loss. Genetic analysis fetal tissues has potential to provide valuable information and is highly recommended some cases. Around 3-4 years ago, gold standard for was GTG Kayrotype, well known that around 50 tissue samples received failed grow culture. Different molecular techniques are used improve quality specificity study, intending circumvent...
Abstract Objectives To determine the causes of fetal death among stillbirths using two classification systems from 22 weeks gestation in a period three years high-risk pregnancies. This is retrospective observational study. Methods The National Institute Perinatal Health Mexico City Level 3 care referral center attending pregnancies throughout country. population consisted patients with during three-year period. Between January 2016 and December 2018, all were examined Pathology Department...
Oxidative stress (OS) induced by SARS-CoV-2 infection may play an important role in COVID-19 complications. However, information on oxidative damage pregnant women with is limited. Objective: We aimed to compare lipid and protein total antioxidant capacity (TAC) between severe non-severe COVID-19. Methods: studied a consecutive prospective cohort of patients admitted the obstetrics emergency department. All positive for reverse transcription-polymerase chain reaction (RT-qPCR) were included....
It has been demonstrated that different organoboron compounds interact with some well-known molecular targets, including serine proteases, transcription factors, receptors, and other important molecules. Several approaches to finding the possible beneficial effects of boronic include various in silico tools. This work aimed find most probable targets for five aromatic acid derivatives. In servers, SuperPred, PASS-Targets, Polypharmacology browser 2 (PPB2) suggested analyzed have anticancer...
Central hypotonic is one of the most difficult issues in neurology, ruling out neurogenetic syndromic causes critical, Prader-Willi syndrome (PWS) it frequent genetic syndrome, caused by loss expression paternal allele a group imprinted genes within 15q11-q13, and characterized severe prenatal postnatal hypotonia. SNURF-SNRPN gene methylation detects 99% cases but fluorescent situ hybridization (FISH) analysis necessary to confirm chromosome microdeletions. The advantage SNRP-quantitative...
FAM20C (family with sequence similarity 20, member C) is a serine/threonine-specific protein kinase that ubiquitously expressed and mainly associated biomineralization phosphatemia regulation. It mostly known due to pathogenic variants causing its deficiency, which results in Raine syndrome (RNS), sclerosing bone dysplasia hypophosphatemia. The phenotype recognized by the skeletal features, are related hypophosphorylation of different bone-target proteins. However, has many targets,...
Age-adjusted rates of cardiovascular disease (CVD) are higher in men than women. CVD risk-factor outcomes underrecognized, underestimated, and undertreated women because the clinical expressions differ from those men. There no universally accepted recommendations on what to do when values fasting glucose, blood pressure, lipids only slightly altered or at borderline values. We reported positive effects risk markers using cacao by-products, showing that alternative approaches can be used...
Antecedentes: Las alteraciones cromosómicas están presentes en 50 a 60 % de los abortos espontáneos y 6 19 mortinatos. Aunque se prefieren microarreglos para estudiarlos, numerosos hospitales no pueden ofrecerlos. Objetivo: Presentar resultados del estudio citogenético 303 productos la concepción (POC), 184 obtuvieron espontáneos, 49 fueron mortinatos 17 identificó edad gestacional. Material métodos: Se empleó cariotipo, hibridación in situ con fluorescencia, secuencias cortas repetidas...
Background: Chromosomal abnormalities are present in 50 to 60% of miscarriages and 6 19% stillbirths.Although microarrays preferred for studying chromosomal abnormalities, many hospitals cannot offer this methodology.Objective: To the results cytogenetic analysis 303 products conception (POC), which included 184 miscarriages, 49 stillbirths 17 cases undefined age.Material methods: Karyotyping, fluorescence situ hybridization, short tandem repeats were used, depending on type loss available...
Aim: Frailty is a syndrome that commonly affects the elderly population and characterized by physical, mental metabolic decline, increasing risk for disability death. The aim of this study was to relationship amongst performance in 6 min walk distance, 2-min step, sit-up, up go tests with frailty its select, pre-identified factors communitydwelling Mexican population. Methods: comprised 170 individuals between 65-90 y old from 5 community centres Mexico City. defined using Fried Phenotype...