A5031223070- Adipose Tissue and Metabolism
- Nuclear Receptors and Signaling
- Biotin and Related Studies
- Protein Degradation and Inhibitors
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- Retinoids in leukemia and cellular processes
- Autophagy in Disease and Therapy
- Blood Coagulation and Thrombosis Mechanisms
- Liver Disease Diagnosis and Treatment
- Signaling Pathways in Disease
- Bioinformatics and Genomic Networks
- Protease and Inhibitor Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Calpain Protease Function and Regulation
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Diabetes Treatment and Management
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Muscle Physiology and Disorders
- Cell Adhesion Molecules Research
- Endoplasmic Reticulum Stress and Disease
- Nanoplatforms for cancer theranostics
Zhongda Hospital Southeast University
2018-2023
Zhejiang Provincial People's Hospital
2023
Southeast University
2021
Southeast University
2018
Kallistatin (KS) has been recognized as a plasma protein with anti-inflammatory functions. Macrophages are the primary inflammatory cells in atherosclerotic plaques. However, it is unknown whether KS plays role macrophage development and pathogenesis of atherosclerosis. This study investigated development, key pathological process An atherosclerosis model was established ApoE−/– mice via partial left carotid artery (PLCA) ligation. adenovirus vector (Ad. HKS) containing human gene delivered...
Background The triglycerides-glucose index (TyG) and the triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) are simple indicators for assessing insulin resistance in epidemiological studies. We aimed clarify relationship between of prognosis non-diabetic acute myocardial infarction (AMI) patients. Methods A total 1,648 AMI patients without diabetes were enrolled from Department Cardiology, Zhongda Hospital, 2012.03 2018.12. medical history, laboratory imaging data collected...
Abstract Abnormal vascular smooth muscle cell (VSMC) proliferation is a critical step in the development of atherosclerosis. Serpina3c serine protease inhibitor (serpin) that plays key role metabolic diseases. The present study aimed to investigate serpina3c atherosclerosis and regulation VSMC possible mechanisms. down-regulated during high-fat diet (HFD)-induced An Apoe−/−/serpina3c−/−-double-knockout mouse model was used determine after HFD for 12 weeks. Compared with Apoe−/− mice,...
Statins are used extensively for the clinical treatment of cardiovascular diseases. Recent studies suggest that statins increase risk new-onset diabetes mellitus (NODM). However, mechanisms statin-induced NODM remain unclear. The present study investigated effects autophagy on insulin secretion impairment induced by rosuvastatin (RS) in rat insulinoma cells (INS-1E) cells. INS-1E were cultured and treated with RS at different concentrations (0.2-20 μM) 24 h. Insulin was detected...
High-fat diet (HFD) can cause obesity, inducing dysregulation of the visceral adipose tissue (VAT). This study aimed to explore potential biological pathways and hub genes involved in obese VAT, for that, bioinformatic analysis multiple datasets was performed. The expression profiles (GSE30247, GSE167311 GSE79434) were downloaded from Gene Expression Omnibus. Overlapping differentially expressed (ODEGs) between normal HFD groups GSE30247 selected run protein–protein interaction network, GO...
Increasing evidence shows that statins increase the risk of new-onset diabetes mellitus, but exact mechanism is not clearly known. Free fatty acid receptor 1 (FFA1) has been recognized to mediate insulin secretion, and pioglitazone direct effects on glucose-stimulated secretion in addition reversion resistance. In this study, we found atorvastatin decreased potassium-stimulated inhibited expression FFA1, PDX-1, BETA2/NeuroD INS-1 cells. Further study demonstrated prevented impairment induced...
Background: Fibrotic remodeling is an essential aspect of heart failure. Kallistatin (KS) inhibited fibrosis after myocardial infarction (MI) but the specific underlying mechanism unknown.Methods: Serpina3c-/- and C57BL/6 mice were used to construct MI model. TGF-β1 or a hypoxic condition was that interfered with cardiac fibroblasts (CFs). RNA-seq assess effect Serpina3c on transcriptome. A total 40 failure patients (HFPs) enrolled, their plasma KS measured using ELISA.Finding: sSerpina3c...
Abstract Background: Adipose tissue remodeling is a dynamic process pathologically expedited in the obese state and related to obesity-associated disease progression closely. This study aimed explore effects of human kallistatin (HKS) on adipose obesity-related metabolic disorders mice fed with high-fat diet (HFD). Methods: Adenovirus-mediated HKS cDNA (Ad.HKS) empty adenovirus (Ad.Null) were constructed injected into epididymal white (eWAT) 8-week old male C57B/L mice. The normal or HFD for...
Abstract Background: Hepatocyte death and liver inflammation have been recognized as central characteristics of nonalcoholic steatohepatitis (NASH); however, the underlying molecular mechanism remains elusive. The aim this study is to determine precise role serpina3c in progression NASH. Methods: Male Apoe -/- /serpina3c double knockout (DKO) mice were fed a high-fat diet (HFD) for 12 weeks induce Several markers steatosis evaluated. In vitro cell models induced by palmitic acid (PA)...