A5087643502- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Visual perception and processing mechanisms
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurobiology and Insect Physiology Research
- Diet and metabolism studies
- Nerve injury and regeneration
- Transcranial Magnetic Stimulation Studies
- Neurogenesis and neuroplasticity mechanisms
- Ion channel regulation and function
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pancreatic function and diabetes
- Organ Transplantation Techniques and Outcomes
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Ion Channels and Receptors
- Memory and Neural Mechanisms
- Axon Guidance and Neuronal Signaling
- Diet, Metabolism, and Disease
- Neuroendocrine regulation and behavior
- Zebrafish Biomedical Research Applications
National Institute for Physiological Sciences
2020-2023
Tokyo Women's Medical University
2004-2019
Center for Integrated Protein Science Munich
2009-2011
Max Planck Institute of Neurobiology
2009
Osaka University
2002-2007
Japan Science and Technology Agency
2006
Kanazawa University
2006
Endogenous cannabinoids (endocannabinoids) mediate retrograde signals for short- and long-term suppression of transmitter release at synapses striatal medium spiny (MS) neurons. An endocannabinoid, 2-arachidonoyl-glycerol (2-AG), is synthesized from diacylglycerol (DAG) after membrane depolarization Gq-coupled receptor activation. To understand 2-AG-mediated signaling in the striatum, we determined precise subcellular distributions synthetic enzyme 2-AG, DAG lipase-α (DAGLα), its upstream...
Eye-opening represents a turning point in the function of visual cortex. Before eye-opening, cortex is largely devoid sensory inputs and neuronal activities are generated intrinsically. After starts to integrate information. Here we used vivo two-photon calcium imaging explore developmental changes mouse by analyzing ongoing spontaneous activity. We found that before activity layer 2/3 neurons consists predominantly slow wave oscillations. These waves were first detected at postnatal day 8...
Tonically active cholinergic interneurons in the striatum modulate activities of striatal outputs from medium spiny (MS) neurons and significantly influence overall functions basal ganglia. Cellular mechanisms this modulation are not fully understood. Here we show that ambient acetylcholine (ACh) derived tonically constitutively upregulates depolarization-induced release endocannabinoids MS neurons. The released cause transient suppression inhibitory synaptic inputs to through acting...
Abstract Endogenous cannabinoids (endocannabinoids) act as retrograde inhibitory messengers in various regions of the brain. We have recently reported that endocannabinoids mediate short‐term suppression excitatory synaptic transmission from neocortex to medium spiny (MS) neurons, major projection neurons striatum. However, it remains unclear whether modulate Here we show depolarization MS induces transient inhibition is mediated by endocannabinoid signalling. By paired recording a...
Noninvasive in vivo calcium imaging was used to observe and characterize inhibitory circuitry intact larval zebrafish. In the teleost hindbrain, network onto major pair of reticulospinal neurons known as Mauthner cells (M-cells) has been described detail. There are three sources inhibition M-cells: recurrent mediated by an ipsilateral collateral M-cell axon, feedforward driven sensory afferents, reciprocal between bilaterally opposed M-cells. To visualize these inhibitions, M-cells were...
Abstract Injury to mature neurons induces downregulated KCC2 expression and activity, resulting in elevated intracellular [Cl − ] depolarized GABAergic signaling. This phenotype mirrors immature wherein GABA-evoked depolarizations facilitate neuronal circuit maturation. Thus, injury-induced downregulation is broadly speculated similarly repair. We test this hypothesis spinal cord motoneurons injured by sciatic nerve crush, using transgenic (CaMKII-KCC2) mice conditional CaMKIIα promoter-KCC2...
The metabotropic glutamate receptor subtype 1 (mGluR1) is a major of group I mGluRs, which contributes to the development and plasticity synapses in brain. In sensory thalamus, thalamocortical neuron receives afferents massive feedback input from corticothalamic (CT) fibers. Notably, mGluR1 more concentrated CT thalamus. visual maintains mature afferent synaptic connectivity. However, it unknown whether strengthening immature or weakening excess during at heterosynaptically regulates...
Hepatic xenotransplantation from guinea-pig to rat has not been established. This failure is partly ascribed differences in hepatic vascular characteristics between two species. However, the resistance distribution and responses vasoconstrictors are known. The present study was designed determine basal levels of segmental resistances histamine noradrenaline isolated livers.The livers were haemoperfused (Hct 8.3%) via portal vein at a constant flow. sinusoidal pressure measured by double...
Abstract Rodents demonstrate defensive behaviors such as fleeing or freezing upon recognizing a looming shadow above them. Although individuals’ experiences in their habitat can modulate the behavior phenotype, effects of systematically manipulating individual’s visual experience on vision-guided have not been studied. We aimed to describe developmental process response threats and deprivation. found that probability escape occurrence increased 3 weeks postnatally, then stabilized. When was...
Abstract Injury to mature neurons induces downregulated KCC2 expression and activity, resulting in elevated intracellular [Cl − ] depolarized GABAergic signaling. This phenotype mirrors immature wherein GABA-evoked depolarizations facilitate neuronal circuit maturation. Thus, injury-induced downregulation is broadly speculated similarly repair. We test this hypothesis spinal cord motoneurons injured by sciatic nerve crush, using transgenic (CaMKII-KCC2) mice conditional CaMKIIα promoter-KCC2...