A5002199929- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Ion channel regulation and function
- Toxoplasma gondii Research Studies
- stochastic dynamics and bifurcation
- Inflammatory mediators and NSAID effects
- DNA Repair Mechanisms
- Medical and Biological Sciences
- DNA and Nucleic Acid Chemistry
- Carcinogens and Genotoxicity Assessment
- Pharmaceutical Economics and Policy
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Hearing, Cochlea, Tinnitus, Genetics
University of Edinburgh
2024
University of Leicester
2022
Institute of Molecular Genetics
2017
Kv3 potassium currents mediate rapid repolarisation of action potentials (APs), supporting fast spikes and high repetition rates. Of the four gene family members, Kv3.1 Kv3.3 are highly expressed in auditory brainstem we exploited this to test for subunit-specific roles at calyx Held presynaptic terminal mouse. Deletion (but not Kv3.1) reduced channel immunolabelling, increased AP duration facilitated excitatory transmitter release; which turn enhanced short-term depression during...
DNA damage is a major cause of replication interruption, mutations, and cell death. removed by several types repair processes. The involvement specialized polymerases in provides an important mechanism that helps tolerate persistent damage. Specialized incorporate nucleotides opposite lesions with high efficiency but demonstrate low accuracy synthesis. In this review, we summarize the mechanisms formation non-bulky lesions, provide overview role translesion
Expansion microscopy (ExM) is an innovative approach to achieve super-resolution images without using microscopes, based on the physical expansion of sample. The advent ExM has unlocked detail for a broader scientific circle, lowering cost and entry skill requirements field. One its branches, ultrastructure (U-ExM), become popular among research groups studying apicomplexan parasites, including acute stage
Abstract Expansion microscopy (ExM) is an innovative approach to achieve super-resolution images without using microscopes, based on the physical expansion of sample. The advent ExM has unlocked imaging for a broader scientific circle, lowering cost and entry skill requirements field. One its branches, ultrastructure (U-ExM), become popular among research groups studying Apicomplexan parasites, including acute stage Toxoplasma gondii infection. chronic cyst-forming , however, resists U-ExM...