A5082316645- Adipose Tissue and Metabolism
- SARS-CoV-2 detection and testing
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- COVID-19 epidemiological studies
- Metabolism, Diabetes, and Cancer
- Computational Drug Discovery Methods
- Diverse Scientific Research Studies
- Regulation of Appetite and Obesity
- Cardiovascular and exercise physiology
- Pancreatic function and diabetes
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Body Composition Measurement Techniques
- Thermoregulation and physiological responses
- Genetics and Physical Performance
- PI3K/AKT/mTOR signaling in cancer
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Muscle Physiology and Disorders
- Thyroid Cancer Diagnosis and Treatment
- Infrared Thermography in Medicine
- Lipid metabolism and disorders
- Viral Infections and Outbreaks Research
University of Miami
2024
Universidade Federal do Rio de Janeiro
2012-2023
Hospital Universitário Clementino Fraga Filho
2014-2017
Rush University Medical Center
2016
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2015-2016
In skeletal muscle, physical exercise and thyroid hormone mediate the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1a) expression that is crucial to muscle mitochondrial function. The of type 2 deiodinase (D2), which activates in upregulated by acute treadmill through a β-adrenergic receptor-dependent mechanism. Pharmacological block D2 or disruption Dio2 gene fibres impaired exercise-induced PGC-1a expression. also citrate synthase activity chronically exercised...
Introduction: Obesity is a major risk factor associated with multiple pathological conditions including diabetes and cardiovascular disease. Endothelial dysfunction an early predictor of obesity. However, little known regarding how endothelial changes trigger In the present work we report novel endothelial-mediated mechanism essential for regulation metabolic homeostasis, driven by c-Myc. Methods: We used conditional knockout (EC-Myc KO) overexpression OE) mouse models to investigate...
Ovariectomy leads to significant increase in body weight, but the possible peripheral mechanisms involved weight gain are still unknown. Since exercise and thyroid hormones modulate energy balance, we aimed study effect of swimming training on brown adipose tissue (BAT) type 2 iodothyronine deiodinase responses ovariectomized (Ox) or sham-operated (Sh) rats. Rats were submitted a period 8-week training, 5 days per week with progressive higher duration protocol. Swimming program did not...
Background . Beetroot consumption has been proposed to improve exercise performance, since the nitrate content of this food is able stimulate synthesis nitric oxide. Objective The acute effect 100 g a beetroot gel containing ~10 mmol was tested on oxide synthesis, metabolic and biochemical parameters, performance in physically active individuals. Methods Through double blind, crossover, placebo-controlled study, 25 healthy runners ingested single dose placebo gels. Participants performed an...
Since the first reported case of COVID-19 in Brazil, public and private educational system started to close. Up November 2020, scientific discussions about return schooling activities have been rarely performed by national community police-makers. The great delay school returning Brazil contrasts with successful international strategies reopening worldwide seems counterintuitive non-essential activities. Here, important issues be considered before during are reviewed discussed. testing is...
After 2 years of the COVID-19 pandemic, protocols used to control infection lack attention and analysis. We present data about deposits complete genomic sequences SARS-CoV-2 in Global Initiative on Sharing All Influenza Data (GISAID) database made between January 2021 May 31, 2022. build distribution profile variants across South America, highlighting contribution influence each variant over time. Monitoring GISAID illustrates negligence follow up infected patients America also discrepancies...
Growth hormone (GH) regulates whole body metabolism, and physical exercise is the most potent stimulus to induce its secretion in humans. The mechanisms underlying GH after remain be defined. aim of this study was elucidate role estrogen pituitary type 1 deiodinase (D1) activation on exercise-induced secretion. Ten days bilateral ovariectomy, animals were submitted 20 min treadmill at 75% maximum aerobic capacity tissues harvested immediately or 30 exercise. Non-exercised used as controls. A...
Myogenesis is positively regulated by thyroid hormone (triiodothyronine [T3]), which amplified the type 2 deiodinase (D2) activation of thyroxine to T3. Global inactivation Dio2 gene impairs skeletal muscle (SKM) differentiation and regeneration in response injury. Given that newborn adult mice with late developmental SKM disruption do not develop a significant phenotype, it was hypothesized D2 plays an early role this process.This tested driven two promoters: MYF5 MYOD.MYF5 myoblasts...
The Brazilian strategy to overcome the spread of COVID-19 has been particularly criticized due lack a national coordinating effort and an appropriate testing program. Here, successful approach control transmission is described by engagement public (university governance) private sectors (hospitals oil companies) in Macaé, state Rio de Janeiro, Brazil, city known as National Oil Capital. In 2020 between 17th 38th epidemiological week, over two percent 206,728 citizens were subjected symptom...
Estrogen deficiency causes metabolic disorders in humans and rodents, including part due to changes energy expenditure. We have shown previously that skeletal muscle mitochondrial function is compromised ovariectomized (Ovx) rats. Since physical exercise a powerful strategy improve content function, we hypothesize training would counteract the deficiency-induced dysfunction Ovx report exercised rats, at 60–65% of maximal capacity for 8 weeks, exhibited less fat accumulation body weight gain...
Life expectancy is increasing worldwide and studies have been demonstrating that elevated serum thyroid stimulating hormone (TSH) concentration in elderly associated with some better health outcomes. This elevation somewhat physiological as aging. The aim of this study was to investigate the heart rate (HR) response during a graded exercise test its recovery healthy elderly, comparing subjects within TSH lower limit reference range those upper limit.A cross-sectional conducted 86 aged 71.5 ±...
Investigate the differences in cardiopulmonary (CP) capacity and Quality of Life (QOL) between healthy elderly (≥ 65 years) with different TSH levels (< 1.0 ≥ μIU/mL) both within normal range. Also, evaluate effects elevation on CP test QOL, by administering methimazole to subjects initial lower-normal TSH, order elevate it superior-normal limit.Initially, a cross-sectional study was performed compare at peak exercise QOL (using WHOQOL-OLD questionnaire) seniors (age < μIU/mL vs. ≥1.0...
Mechanistic target of rapamycin complex 1 (mTORC1) deficiency or chronic hyperactivation in pancreatic β-cells leads to diabetes. mTORC1 complexes with La-related protein (LARP1) specifically regulate the expression 5' terminal oligopyrimidine tract (5'TOP) mRNAs which encode proteins translation machinery and ribosome biogenesis. Here we show that LARP1 is most expressed LARP mouse islets human β-cells, being 2-4-fold more abundant than LARP1B, a member family also interacts mTORC1....
At the end of 2019 a new coronavirus surfaced in China, SARS-CoV-2, responsible for ongoing pandemic. There is need novel and stable therapies to help patients COVID-19. Drug repositioning strategy quickly find medicines already used treatment another pathology. In this work, we PLpro as molecular target it being cleaving other viral proteins interfering with immune system. Brazilian Pharmacopeia described many different Active Pharmaceutical Ingredients (API) Brazil world. Using silico...
At the end of 2019 a new coronavirus surfaced in China, SARS-CoV-2, responsible for ongoing pandemic. There is need novel and stable therapies to help patients COVID-19. Drug repositioning strategy quickly find medicines already used treatment another pathology. In this work, we PLpro as molecular target it being cleaving other viral proteins interfering with immune system. Brazilian Pharmacopeia described many different Active Pharmaceutical Ingredients (API) Brazil world. Using silico...
ABSTRACT Mechanistic target of rapamycin complex 1 (mTORC1) is a cellular rheostat linking nutrient availability and growth factor to protein translation. In pancreatic insulin secreting β-cells, mTORC1 deficiency or chronic hyperactivation leads diabetes. complexes with La-related (LARP1) specifically regulate the expression 5’ terminal oligopyrimidine tract (5’TOP) mRNAs which encode proteins translation machinery ribosome biogenesis. We aimed investigate role played by LARP1 in β-cells...
Abstract Background Brazilian strategy to overcome the spread of COVID-19 has been particularly criticized due lack a national coordinating effort and an appropriate testing program. Here, successful approach control transmission is described by engagement public (university governance) private sectors (hospitals oil companies) in Macaé, state Rio de Janeiro, Brazil, city known as National Oil Capital. Methods Until 38th epidemiological week, over two percent 206,728 citizens were subjected...