A5024561768- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Pituitary Gland Disorders and Treatments
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Circadian rhythm and melatonin
- Gut microbiota and health
- Health Systems, Economic Evaluations, Quality of Life
- Bipolar Disorder and Treatment
- Impact of Technology on Adolescents
University of California, San Francisco
2022
San Francisco VA Medical Center
2016-2019
Northern California Institute for Research and Education
2016-2019
University of Tennessee Health Science Center
2016
National Institute of Environmental Health Sciences
2016
University of California, Los Angeles
2015-2016
University of Pittsburgh
2016
National Institute on Aging
2016
California Pacific Medical Center
2016
Neurobehavioral Systems
2015
Prior studies indicate that olfactory function may be an early marker for cognitive impairment, but the body of evidence has been largely restricted to white populations.We studied 2,428 community-dwelling black and older adults (baseline age 70-79 years) without dementia enrolled in Health, Aging, Body Composition (Health ABC) study. Olfaction was measured as odor identification (OI) with 12-item Cross Cultural Smell Identification Test year 3. We defined incident over 12 years on basis...
Significance Characterizing the abnormalities in sleep and activity that are associated with bipolar disorder (BP) identifying their causation key milestones unraveling biological underpinnings of this severe highly prevalent disorder. We have conducted first systematic evaluation phenotypes pedigrees include multiple BP-affected members. By delineating specific measures significantly heritable these families, those whose variation correlated BP status members, by determining chromosomal...
Stress-associated disruptions in the development of frontolimbic regions may play a critical role emergence adolescent-onset depression. These are particularly sensitive to Hypothalamic-Pituitary-Adrenal (HPA) axis signaling. The HPA is hyperactive adolescent depression, and interventions that attenuate such hyperactivity hold promise as potential treatments. Microbiome-Gut-Brain (MGB) an important pathway through which stress dysregulates HPA-axis activity thus exerts deleterious effects on...
Olfactory testing may be an effective marker for cognitive impairment (CI) and dementia, but no studies have explored this association in older veterans, a vulnerable group with high burden of chronic conditions. Independently living veterans (n = 59) completed neuropsychological battery—assessing three domains: learning/memory, language, executive function—and olfactory identification (OI) assessment. Lower OI performance was significantly associated worse memory function (p trend 0.03 .05)...