A5055320904- Cell death mechanisms and regulation
- Oral microbiology and periodontitis research
- Oral and gingival health research
- Cancer-related Molecular Pathways
- Plasma Applications and Diagnostics
- Erythrocyte Function and Pathophysiology
- Periodontal Regeneration and Treatments
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Bone Tissue Engineering Materials
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
- Bone health and treatments
- Protease and Inhibitor Mechanisms
- Oral and Maxillofacial Pathology
- Essential Oils and Antimicrobial Activity
- Tendon Structure and Treatment
- Dental materials and restorations
- Bone and Joint Diseases
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Receptor Mechanisms and Effects
University of Chieti-Pescara
2016-2025
Bridge University
2023
Kafrelsheikh University
2023
Kwangwoon University
2023
Ospedale di Santo Spirito
2017-2019
Barcelona Institute for Science and Technology
2017
Universitat Pompeu Fabra
2017
Institute of Science and Technology
2017
Istituto di Genetica Molecolare
2009
Istituto Superiore di Sanità
2004-2005
Cannabidiol (CBD) and cannabigerol (CBG) are Cannabis sativa terpenophenols. Although CBD’s effectiveness against neurological diseases has already been demonstrated, nothing is known about CBG. Therefore, a comparison of the effects these compounds was performed in two experimental models mimicking oxidative stress neurotoxicity occurring diseases. Rat astrocytes were exposed to hydrogen peroxide cell viability, reactive oxygen species production apoptosis occurrence investigated. Cortexes...
Background Nanoplastics, an emerging form of pollution, are easily consumed by organisms and pose a significant threat to biological functions due their size, expansive surface area, potent ability penetrate systems. Recent findings indicate increasing presence airborne nanoplastics in atmospheric samples, such as polystyrene (PS), raising concerns about potential risks the human respiratory system. Methods This study investigates impact 800 nm diameter-PS nanoparticles (PS-NPs) on A549,...
Industrial hemp is a multiuse crop whose phytocomplex includes terpenophenolics and flavonoids. In the present study, phenolic terpenophenolic compounds were assayed in water extract of variety Futura 75. Protective effects also investigated human fibroblast keratinocytes isolate mouse skin specimens, which exposed to hydrogen peroxide and/or (1–500 µg/mL). The results phytochemical analysis suggested cannabidiol, cannabidiolic acid rutin as prominent phytocompounds. vitro system represented...
Vitis vinifera (grape) contains various compounds with acknowledged phytochemical and pharmacological properties. Among the different parts of plant, pomace is particular interest as a winemaking industry by-product. A characterization water extract from grape Montepulciano d'Abruzzo variety (Villamagna doc) was conducted, bioactive phenolic were quantified through HPLC-DAD-MS analysis. HypoE22, hypothalamic cell line, challenged an oxidative stimulus exposed to concentrations (1 µg/mL-1...
Hyaluronic Acid (HA) has been already approved by Food and Drug Administration (FDA) for osteoarthritis (OA), while its use in the treatment of tendinopathy is still debated. The aim this study was to evaluate human rotator cuff tendon derived cells effects four different HA on cell viability, proliferation, apoptosis expression collagen type I III. An vitro model developed from tears preparations (Ps) (sodium hyaluronate MW: 500-730 KDa - Hyalgan®, 1000 kDa Artrosulfur HA®, 1600 Hyalubrix®...
Pancreatic cancer (PC) is one of the most lethal, chemoresistant malignancies and it paramount importance to find more effective therapeutic agents. Repurposing non-anticancer drugs may expand repertoire molecules. Studies on repurposing benzimidazole-based anthelmintics in PC their interaction with agents approved for therapy are lacking. We analyzed effects four Food Drug Administration (FDA)-approved benzimidazoles AsPC-1 Capan-2 pancreatic cell line viability. Notably, parbendazole was...
Background: Cannabidiol (CBD) and cannabigerol (CBG) are non-psychotropic terpenophenols isolated from Cannabis sativa, which, besides their anti-inflammatory/antioxidant effects, able to inhibit, the first, stimulate, second, appetite although there no studies elucidating role in hypothalamic appetite-regulating network. Consequently, aim of present research is investigate CBD CBG regulating neuromodulators. Comparative evaluations between oxidative stress food intake-modulating mediators...
Pancreatic cancer (PC) is one of the deadliest malignancies, with an increasing incidence and limited response to current therapeutic options. Therefore, more effective low-toxic agents are needed improve PC patients' outcomes. Resveratrol (RSV) a natural polyphenol multiple biological properties, including anticancer effects. In this study, we explored antiproliferative activities newly synthetized RSV analogues in panel cell lines evaluated physicochemical properties most active compound....
Diabetic polyneuropathy is characterized by structural abnormalities, oxidative stress, and neuroinflammation. The current study aimed to determine the antinociceptive effects of isoeugenol eugenol their combinations in neuropathic pain resulting from streptozotocin (STZ)-induced diabetes Female SD rats were categorized into normal control, diabetic treatment groups. On 28th day 45th day, behavioral studies (allodynia hyperalgesia) performed analyze development protection polyneuropathy....
Abstract Objective Cold atmospheric plasma (CAP) is a novel approach for cancer treatment. It can be used to treat liquids—plasma‐activated media (PAM)—which are then transferred the target as an exogenous source of reactive oxygen and nitrogen species (RONS). The present study aimed at chemically characterizing different PAM assessing their in vitro selectivity against head neck cells (HNC). Methods were obtained by exposing 2 5 mL cell culture medium CAP 5, 10 20 min 6 mm working distance....
Abstract Paragangliomas (PGLs) are infiltrating autonomic nervous system tumors that cause important morbidity. At present, surgery is the only effective therapeutic option for this rare tumor. Thus, new agents PGL treatment should be identified. Using unique cell models established in our laboratory, we evaluated effect of dichloroacetate (DCA) as single agent or a novel combination with other metabolic drugs, including GW6471 and metformin. DCA metformin had not been tested before PGL....
Background: In melanoma, multiligand drug strategies to disrupt cancer-associated epigenetic alterations and angiogenesis are particularly promising. Here, a novel dual-ligand with single shared pharmacophore capable of simultaneously targeting histone deacetylases (HDACs) sigma receptors (σRs) was synthesized subjected phenotypic in vitro screening. Methods: Tumor cell proliferation spreading were investigated using immortalized human cancer normal lines. Angiogenesis also evaluated mouse...
The vascular system is primarily responsible for orchestrating the underlying healing processes to achieve tissue regeneration, thus promotion of angiogenic events could be a useful strategy repair injured tissues. Among several approaches stimulate non-invasive devices are currently widely diffused. Complex Magnetic Fields (CMFs) innovative pulsed multifrequency electromagnetic fields used their promising results in clinical applications, such as diabetic foot treatment or edema resorption....
A novel cyclic prodrug of S-allyl-glutathione (CP11), obtained by using an acyloxy-alkoxy linker, was estimated for its pharmacokinetic and biological properties. The stability CP11 evaluated at pH 1.2, 7.4, in simulated fluids with different concentrations enzymes, human plasma. anti-inflammatory ability assessed U937 cells, immortalized monocyte cell line. Results showed that is stable acidic showing a possible advantage oral delivery due to the longer permanence stomach. Having...
Head and neck paragangliomas (HNPGLs) are rare tumors that may cause important morbidity, because of their tendency to infiltrate the skull base. At present, surgery is only therapeutic option, but radical removal be difficult or impossible. Thus, effective targets molecules for HNPGL treatment need identified. However, lack cellular models this tumor hampers task. PPARα receptor activation was reported in several appears a promising target different malignancies. Considering role HNPGLs...
Dental pulp stem cells (DPSCs) represent a population of which could be useful in oral and maxillofacial reconstruction. They are part the periendothelial niche, where their crosstalk with endothelial is crucial cellular response to biomaterials used for dental restorations. DPSCs cell line EA.hy926 were co-cultured presence Chitlac-coated thermosets culture conditions inducing, turn, osteogenic or angiogenic differentiation. Cell proliferation was evaluated by...