A5051862611- Pharmacological Effects of Medicinal Plants
- Bone Metabolism and Diseases
- Enzyme Catalysis and Immobilization
- Geomagnetism and Paleomagnetism Studies
- Metal Extraction and Bioleaching
- Wnt/β-catenin signaling in development and cancer
- Microbial Metabolic Engineering and Bioproduction
- Carbohydrate Chemistry and Synthesis
- Additive Manufacturing Materials and Processes
- Enzyme Production and Characterization
- Titanium Alloys Microstructure and Properties
- Cancer-related gene regulation
- Minerals Flotation and Separation Techniques
- Cellular transport and secretion
- Aluminum Alloy Microstructure Properties
- Ubiquitin and proteasome pathways
- High Entropy Alloys Studies
- Erosion and Abrasive Machining
- Hydrogen Storage and Materials
- Ammonia Synthesis and Nitrogen Reduction
- Hippo pathway signaling and YAP/TAZ
- Additive Manufacturing and 3D Printing Technologies
- Protein Hydrolysis and Bioactive Peptides
- Endoplasmic Reticulum Stress and Disease
- Advanced materials and composites
Chinese Academy of Sciences
2016-2023
Xuzhou Medical College
2014-2023
Guangdong Pharmaceutical University
2016-2023
Kunming Institute of Botany
2016-2023
Institute of Modern Physics
2021-2022
South China Sea Institute Of Oceanology
2019-2021
Institute of Oceanology
2019-2021
Shenzhen Institutes of Advanced Technology
2021
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2021
University of Chinese Academy of Sciences
2019
The identification of genes involved in carcinogenesis and tumor progression is great interest, since these might be possible as candidates for new targeted therapy strategies. Our previous study shows that Golgi phosphoprotein 3 (GOLPH3) glioma cell migration invasion, the critical characteristics malignant gliomas. In this study, we explored mechanism GOLPH3 affecting invasion found promotes glioblastoma (GBM) via mammalian target rapamycin(mTOR)‐Y‐box binding protein‐1 (YB1) pathway...
Commiphoranes A–D (1–4), four novel aromatic terpenoids with unprecedented carbon skeletons, were isolated from Resina Commiphora. Their structures identified by spectroscopic and crystallographic methods. Compounds 1 2 are dinorditerpenoids characteristic of a 6/6/6/6 ring system. In contrast, compounds 3 4 sesquiterpenoids possessing 5/6/7 backbone. Biological evaluation reveals that could significantly attenuate overproduction fibronectin, collagen I, α-SMA in TGF-β1-induced rat renal...
The new sesquiterpene dimers commiphoroids A-D (1-4) were isolated from Resina Commiphora, and their structures assigned by spectroscopic methods X-ray diffraction analysis. Compounds 1 2 are stereoisomers of putative [2 + 4]-cycloaddition reactions, 3 is a trinorsesquiterpene dimer containing 6/6/5/6/6/6 hexacyclic framework, while 4 possesses 8-oxabicyclo[3.2.1]oct-6-ene skeletal core. Plausible biosynthetic pathways for 1-4 proposed. Biochemical studies show that compound promotes ca. 60%...
Commiphorines A (<bold>1</bold>) and B (<bold>2</bold>), two dimeric sesquiterpenoids featuring unusual polycyclic systems, intermediates <bold>3</bold> <bold>4</bold>, were isolated from <italic>Resina Commiphora</italic>.
Bacterial magnetosomes had been proved to have great application potential in medicine and biotechnology. The objective of the present study was obtain high yield from Acidithiobacillus ferrooxidans ( A. ferrooxidans) BYM an airlift bioreactor using response surface methodology (RSM). were characterized a transmission electron microscope scanning microscopy. maximum magnetosome 0.4267 mg/L achieved at ventilation capacity 3.6 L/min gluconic acid concentration 10 mmol/L 25 o C. correlation...
Background/Aims: Golgi phosphoprotein 3 (GOLPH3) plays pro-malignancy roles in several types of cancer. However, the molecular mechanism underlying GOLPH3 promoting tumor progression remains poorly understood. Methods: The expression and Wntless (Wls) glioma tissues was examined by western blotting immunohistochemistry. EdU incorporation assay colony formation used to examine cell growth ability. effect on Wls recycling, Wnt secretion β-catenin activity detected using blotting,...
Main observation and conclusion Commiphoroids G1—G3, H I (1—5), five new terpenoid dimers were isolated from Resina Commiphora . Their structures absolute configurations determined by using spectroscopic, computational crystallographic methods. Biological evaluation of these against renal fibrosis reveals that 5 inhibits extracellular matrix components including fibronectin collagen in a concentration‐dependent manner.
Four new germacrane-type sesquiterpenes commiphoranes M1-M4 (1-4) together with eighteen were isolated from the Resina Commiphora. The structures and relative configurations of substances determined by using spectroscopic methods. Biological activity investigation revealed that nine compounds including 7, 9, 14, 16, (+)-17, (-)-17, 18, 19, 20 could induce apoptosis prostate cancer originated PC-3 cells, through classic signaling pathway, even flow cytometry showed compound (+)-17 caused...
Bacillus sp. DL-1 was isolated from the deep sea of Western Pacific Ocean and behaved very good resistance to NaCl. The extracellular proteases were found exhibit excellent enantioselectivity for kinetic resolution (±)-1-phenylethyl acetate. To improve stability enzyme, immobilized preparated by using 60 g kieselguhr 1-L crude fermentation broth containing DL-1, shaking at 25 °C, 200 r/min 10 h. Every gram adsorbed 25.7 mg protease enzymatic activity recovery 79.86%. preserved about 35.8%...
Chiral 1-phenylethanol and its ester derivative are important chiral chemicals in diverse industries the preparation of those optically pure enantiomers is great importance. One bacterium, Bacillus sp. DL-2, whose extracellular proteases could efficiently asymmetrically hydrolyse (±)-1-phenylethyl acetate, was isolated from deep sea Western Pacific. After immobilization optimization enzymatic reactions, (R)-1-phenylethanol prepared with enantiomeric excess (e.e.) being 97% yield 41%,...