A5037084320- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Legionella and Acanthamoeba research
- interferon and immune responses
- Prostate Cancer Treatment and Research
- Cancer-related Molecular Pathways
- Endoplasmic Reticulum Stress and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Lipids, and Metabolism
Max Planck Institute for Biology of Ageing
2021-2023
McGill University Health Centre
2021
The outer mitochondrial membrane (OMM) is essential for cellular homeostasis. Yet little known of the mechanisms that remodel it during natural stresses. We found large “SPOTs” (structures positive OMM) emerge Toxoplasma gondii infection in mammalian cells. SPOTs mediated depletion OMM proteins mitofusin 1 and 2, which restrict parasite growth. formation depended on effector TgMAF1 host import receptor TOM70, required optimal proliferation. TOM70 enabled to interact with translocase SAM50....
High mortality of prostate cancer patients is primarily due to metastasis. Understanding the mechanisms controlling metastatic processes remains essential develop novel therapies designed prevent progression from localized disease CdGAP plays important roles in control cell adhesion, migration, and proliferation, which are central progression. Here we show that elevated expression associated with early biochemical recurrence bone metastasis patients. Knockdown castration-resistant (CRPC)...