A5054537085- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Amyotrophic Lateral Sclerosis Research
- Histone Deacetylase Inhibitors Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Caveolin-1 and cellular processes
- Natural Compound Pharmacology Studies
- Vitamin D Research Studies
- Biochemical Acid Research Studies
- Photoreceptor and optogenetics research
- Pancreatitis Pathology and Treatment
- Autophagy in Disease and Therapy
- Psychedelics and Drug Studies
- Attention Deficit Hyperactivity Disorder
- Lipid metabolism and disorders
- Neurogenetic and Muscular Disorders Research
- Mercury impact and mitigation studies
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Heavy Metal Exposure and Toxicity
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Obsessive-Compulsive Spectrum Disorders
University of Oklahoma Health Sciences Center
2025
University of Calgary
2024
University of Verona
2022
Afe Babalola University
2015
Institute of Neurobiology
2015
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder. There no cure and current treatments fail to slow the progression of disease. Epigenetic modulation in acetylation state NF-kB RelA histone 3 (H3) protein, involved development neurodegeneration, drugable target for class-I deacetylases (HDAC) inhibitors, entinostat or valproate, AMP-activated kinase (AMPK)-sirtuin 1 pathway activator, resveratrol. In this study, we demonstrated that combination valproate...
Background: fourth generation antipsychotics have been implicated in the blockade of calcium signalling through inhibition dopamine receptive sites on dopaminergic D2 Receptor (D3R). As a result abnormal associated with D2R inhibition, changes occur motor and memory neural axis leading to observed behavioural deficits after prolonged haloperidol. Thus, Vitamin D3 receptor (VD3R), controlling striatum can be targeted relief neurological symptoms haloperidol (-D2R) induced PD. Aim: This study...
Haloperidol-induced dyskinesia has been linked to a reduction in dopamine activity characterized by the inhibition of receptive sites on D2-receptor (D2R). As result D2R inhibition, calcium-linked neural is affected and seen as decline mo-tor-cognitive function after prolonged haloperidol use treatment psychotic disorders. In this study, we have elucidated relationship between haloperidol-induced tardive motor cortex (M1), basal nucleus (CPu), prefrontal (PFC) hippocampus (CA1). Also,...
AbstractThe role of dopaminergic D2 receptor (D2R) autoregulation in dopamine (DA) neurotransmission cannot be overemphasized cause and progression disorders associated with complex behaviors. Although previous studies have shown that D2R is structurally physiologically linked calcium/calmodulin-dependent kinase II (CaMKIIα), however, the calmodulin CaMKIIα regulation remains elusive. In this study, using structural biology modeling softwares (iGEMDOCK CueMol), we interaction between D2R,...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder involving motor neuron (MN) loss in the cortex, brainstem and spinal cord leading to progressive paralysis death. Due pathogenetic complexity, there are no effective therapies available. In this context use of mesenchymal stem cells their vesicular counterpart an emerging therapeutic strategy counteract neurodegeneration. The extracellular vesicles derived from adipose (ASC-EVs) recapitulate ameliorate neuroprotective effect...
Abstract The mechanisms underlying the earlier onset and male predominance of amyotrophic lateral sclerosis (ALS), most common form human motoneuron disease, are poorly understood. Here we show that gut microbiota protects against TDP43 toxicity contributes to sexual dimorphism in mice expressing a mutant (A315T) linked ALS. raised under germ-free conditions, or treated with antibiotics deplete microbiota, develop disease no sex differences lifespan. Behavioral histopathological analyses...
The effect of haloperidol on neonatal dopaminergic neurotransmission in the hippocampus postnatal day 20 rats (P.20) was investigated this study. Haloperidol blocked dopamine receptors (D2R) and inhibited D2R membrane neonate neurons. For study 0.5 ml (20 mg/kg) administered to pregnant female animals intraperitoneally a week before delivery. At P.20, 5 control treated were taken behavioral studies room for Y maze Novel object recognition test, which done 7 am morning mating....
Abstract Increased exploitation of minerals has led to pollution confined environments as documented in Nigeria Niger Delta. Information on the effects brain such exposure is limited. Due its exploratory activities, African giant rat ( Cricetomys gambianus ) (AGR) provides a unique model for neuroecotoxicological research determine levels animal and human different pollutants. This study aims unravel neuropathological features AGR sampled from three agro-ecological zones Nigeria. Fifteen...