A5079967889- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Immunotherapy and Immune Responses
- Memory and Neural Mechanisms
- Heavy Metal Exposure and Toxicity
- Vanadium and Halogenation Chemistry
- Anesthesia and Neurotoxicity Research
- Immune cells in cancer
- Neuropeptides and Animal Physiology
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Receptor Mechanisms and Effects
- Mercury impact and mitigation studies
- Nanoparticles: synthesis and applications
- Genetic and phenotypic traits in livestock
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Therapeutic Uses of Natural Elements
- Animal Genetics and Reproduction
- Traumatic Brain Injury and Neurovascular Disturbances
- Nicotinic Acetylcholine Receptors Study
- Cardiac Ischemia and Reperfusion
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Adenosine and Purinergic Signaling
- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
University of Verona
2007-2024
American Nephrology Nurses Association
2019
University of Ibadan
2016
Instituto Cajal
2007
Environmental exposure to vanadium occurs in areas of persistent burning fossil fuels; this metal is known induce oxidative stress and oligodendrocyte damage. Here, we determined whether (3 mg/kg) mice during the first 3 postnatal months leads a sustained neuroinflammatory response. Body weight monitoring, muscle strength open field tests showed reduction body gain locomotor impairment vanadium-exposed mice. Myelin histochemistry immunohistochemistry for astrocytes, microglia,...
Vanadium, a transition series metal released during some industrial activities, induces oxidative stress and lipid peroxidation. Ameliorative effect of pure compound from the methanolic extract Moringa oleifera leaves, code-named MIMO2, in 14-day old mice administered with vanadium (as sodium metavanadate 3 mg/kg) for 2 weeks was assessed. Results body weight monitoring, muscular strength, open field showed slight reduction locomotion deficit vanadium-exposed mice, ameliorated MIMO2...
Astrocytic networks and gap junctional communication mediated by connexins (Cxs) have been repeatedly implicated in seizures, epileptogenesis, epilepsy. However, the effect of seizures on Cx expression is controversial. The present study focused response Cxs to status epilepticus (SE), which turn an epileptogenic insult. neuronal Cx36 astrocytic Cx30 Cx43 mRNAs was investigated brain rats first day after pilocarpine-induced SE. In situ hybridization revealed a progressive decrease mRNA...
Transgenic mice expressing fluorescent proteins in specific cell populations are widely used for vivo brain studies with two-photon fluorescence (TPF) microscopy. Mice of the thy1GFP-M line have been engineered selective expression green protein (GFP) neuronal populations. Here, we report that TPF microscopy reveals, at surface these mice, also motile non-neuronal GFP+ cells. We analyzed behavior cells and characterized sections their immunophenotype. With imaging, were found meninges,...
Abstract Previous studies demonstrated that the spiny rat Proechimys guyannensis exhibits resistance to experimental epilepsy. Neural activation was studied in hippocampus, using Fos induction, within 24 h after pilocarpine‐induced seizures; neurodegenerative events were investigated parallel, FluoroJade B histochemistry. These parameters selected since limbic epilepsy is known elicit immediate early gene expression and cell loss hippocampus of seizure‐prone laboratory rodents. At variance...
To analyze cellular mechanisms of limbic-seizure suppression, the response to pilocarpine-induced seizures was investigated in cortex and thalamus, comparing epilepsy-resistant rats Proechimys guyannensis with Wistar rats.Fos immunoreactivity revealing neuronal activation, degenerating neurons labeled by Fluoro-Jade B (FJB) histochemistry were analyzed on first day after onset lasting 3 h. Subpopulations gamma-aminobutyric acid (GABA)ergic cells characterized double Fos-parvalbumin...
Calabash chalk (CaC) is an aluminium silicate hydroxide compound with heavy metal constituents, making it a potential neurotoxicant. Pregnant women often consume CaC as antiemetic, which may interfere the normal development of foetal brain. Here, we evaluated effects administration in pregnant rats on brain offspring. Wistar rat dams were assigned to one three groups: control, 200 mg/kg and 800 suspension. Administrations lasted 14 days (gestation 7-20). On day 14, 5-bromo-2'-deoxyuridine...
Dendritic cells (DCs) are a subset of leukocytes highly specialized in antigen-presentation to T cells, thus promoting the immune response. DCs occur meninges and choroid plexus. Brain brain-derived antigens drained by cerebrospinal fluid afferent lymphatic vessels cervical lymph nodes (cLNs) for antigen presentation. Information on role intracerebral response is still limited. We recently demonstrated (Laperchia et al., 2013) that thy1GFP-M transgenic mice, engineered expression green...
A wealth of recent evidence indicates that microglia activation is a polarized process, leading to potentially neurotoxic M1 “classical activation” or neuroprotective M2 “alternative activation”. The regulation this process is, however, still largely unknown. We here investigated the induction molecules which characterize and responses after systemic (ip) central (intracerebroventricular, icv) exposure lipopolysaccharide (LPS). These challenges elicit different inflammatory brain parenchyma;...
Reports 7 (2019) S2-S51 S19 hydroxylase-TH and Monoamine Oxidase B-MAO-B), microglia activation (CD11b), pro-inflammatory (IL-1), oxidative stress (p47phox) biomarkers using Western immunoblot.Data was analyzed by one-way ANOVA (Tukey post hoc), with the level of significance set at p < 0.05.6-hydroxydopamine-induced striatal lesion caused deficit in contralateral use forepaw (cylinder test), a reduction number line crossed (open field test) cognitive impairment (Novel object recognition...
they can be studied and treated using Drosophila as a model.
Over the past decade, multiple data regarding local opioid regulation of heart function have been demonstrated. However, receptors (ORs) not yet characterized in post-heart transplantation. Since a transplanted is devoid innervations and autonomic modulate ORs, we assessed hypothesis that possible down-regulation k-OR δ-OR transplants. Endomyocardial biopsies were collected 15 male patients at 30 days orthotopic transplantation control during aortic valve surgery human. Another study...
Abstract Increased exploitation of minerals has led to pollution confined environments as documented in Nigeria Niger Delta. Information on the effects brain such exposure is limited. Due its exploratory activities, African giant rat ( Cricetomys gambianus ) (AGR) provides a unique model for neuroecotoxicological research determine levels animal and human different pollutants. This study aims unravel neuropathological features AGR sampled from three agro-ecological zones Nigeria. Fifteen...