A5035378405- Neuroscience and Neuropharmacology Research
- Polysaccharides and Plant Cell Walls
- Receptor Mechanisms and Signaling
- Adenosine and Purinergic Signaling
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Epilepsy research and treatment
- Fibroblast Growth Factor Research
- Nicotinic Acetylcholine Receptors Study
- Nuclear Receptors and Signaling
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Muscle Physiology and Disorders
- Biochemical and Structural Characterization
- Seaweed-derived Bioactive Compounds
- Neuroscience of respiration and sleep
- Connexins and lens biology
- Phytochemicals and Antioxidant Activities
- Tryptophan and brain disorders
- Veterinary Pharmacology and Anesthesia
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Biochemical effects in animals
University of Palermo
2016-2025
Ludwig-Maximilians-Universität München
2018-2021
Clinica Luganese Moncucco
2006-2016
University of Rome Tor Vergata
2015
Washington University in St. Louis
2012-2014
Tecnologie Avanzate (Italy)
2007-2014
Lemon IntegroPectin obtained via hydrodynamic cavitation of organic lemon processing waste in water shows significant neuroprotective activity vitro, as first reported this study investigating the effects both and commercial citrus pectin on cell viability, morphology, reactive oxygen species (ROS) production, mitochondria perturbation induced by treatment neuronal SH-SY5Y human cells with H2O2. Mediated ROS, including H2O2 its derivatives, oxidative stress alters numerous cellular...
Helium isotope ratios of olivine and pyroxene phenocrysts from Plio‐Quaternary volcanic rocks southern Italy (seven Aeolian Islands, Mt. Vulture, Etna, Ustica, Pantelleria) range 2.3 to 7.1 R a . Importantly, the phenocryst 3 He/ 4 He correlate well with whole rock Sr isotopic composition (0.70309–0.70711), reflecting mixing two sources. A significant contribution crustal contamination is recorded only occasionally (e.g., pyroxenes Vulcano). When merged data Roman Comagmatic Province,...
Metabolic Syndrome (MetS) is an extremely complex disease. A non-balanced diet such as high-fat (HFD) induces metabolic dysfunction that could modify redox homeostasis. We here aimed at exploring homeostasis in male Wistar rats, following 8 weeks of HFD, correlating the eventual modification selected biomarkers be associated with clinical manifestations MetS. Therefore, we parameters relative to both glucose tolerance and lipid altered metabolism, but also oxidative pattern. assessed some...
A wealth of evidence underscores the bioactive properties nutraceuticals and functional foods in addressing oxyinflammatory-based diseases with implications at both peripheral central levels. Opuntia ficus-indica (OFI) is well-documented for its health-promoting attributes, though fruit (OFIF) remains relatively understudied. Not only poses Metabolic Syndrome (MetS) cardiometabolic risks but also contributes significantly to cognitive impairment, especially crucial brain areas such as...
Metabotropic glutamate (mGlu) receptors have been considered potential targets for the therapy of experimental parkinsonism. One hypothetical advantage associated with use mGlu receptor ligands is lack adverse effects typically induced by ionotropic antagonists, such as sedation, ataxia, and severe learning impairment. Low doses mGlu2/3 metabotropic agonist, LY379268 (0.25-3 mg/kg, i.p.) increased glial cell line-derived neurotrophic factor (GDNF) mRNA protein levels in mouse brain, assessed...
Rodent epilepsy models can significantly contribute to our understanding of pathophysiological mechanisms and validation biomarker target candidates. Evidence-based severity assessment is a presupposition for the ethical evaluation animal experimentation allowances as well development efficacious refinement concepts.Aiming improve impact experimental procedures repeated seizures, we have completed comprehensive behavioral biochemical analysis assessing various parameters that inform about...
The differentiation of neural progenitors is a complex process that integrates different signals to drive transcriptional changes, which mediate metabolic, electrophysiological, and morphological cellular specializations. Understanding these adjustments essential within the framework stem cell cancer research therapy. Human neuroblastoma SH-SY5Y cells, widely used in neurobiology research, can be differentiated into neuronal-like cells through serum deprivation retinoic acid (RA)...
Dravet syndrome is a rare, severe pediatric epileptic encephalopathy associated with intellectual and motor disabilities. Proteomic profiling in mouse model of can provide information about the molecular consequences genetic deficiency pathophysiological mechanisms developing during disease course. A knock-in Scn1a haploinsufficiency was used for whole proteome, seizure, behavioral analysis. Hippocampal tissue dissected from two- (prior to epilepsy manifestation) four- (following week-old...
Astrocytic networks and gap junctional communication mediated by connexins (Cxs) have been repeatedly implicated in seizures, epileptogenesis, epilepsy. However, the effect of seizures on Cx expression is controversial. The present study focused response Cxs to status epilepticus (SE), which turn an epileptogenic insult. neuronal Cx36 astrocytic Cx30 Cx43 mRNAs was investigated brain rats first day after pilocarpine-induced SE. In situ hybridization revealed a progressive decrease mRNA...
In this study, we investigated the beneficial effects of grapefruit IntegroPectin, derived from industrial waste peels via hydrodynamic cavitation, on microglia cells exposed to oxidative stress conditions. Grapefruit IntegroPectin fully counteracted cell death and apoptotic process induced by exposure tert-butyl hydroperoxide (TBH), a powerful hydroperoxide. The protective were accompanied with decrease in amount ROS, strictly dependent activation phosphoinositide 3-kinase (PI3K)/Akt...
Imparted with uniquely high and broad-scope bioactivity including antioxidant, anti-inflammatory, cardioprotective, neuroprotective, antimicrobial anticancer properties, the IntegroPectin phytocomplex obtained from citrus processing waste via hydrodynamic cavitation (HC) was investigated Density Functional Theory. The main flavonoids of grapefruit (naringenin), orange (hesperidin), lemon (eriocitrin) were taken into account along a model structure for pectin RG-I rhamnogalacturonan chains....