A5076377502- Gastrointestinal motility and disorders
- Adenosine and Purinergic Signaling
- Neuropeptides and Animal Physiology
- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Ion channel regulation and function
- RNA and protein synthesis mechanisms
- Helicobacter pylori-related gastroenterology studies
- Masonry and Concrete Structural Analysis
- Neuroscience and Neuropharmacology Research
- Infant Health and Development
- Inflammatory mediators and NSAID effects
- Muscle Physiology and Disorders
- Neuroscience of respiration and sleep
- Inflammatory Bowel Disease
- Pharmacological Receptor Mechanisms and Effects
- RNA modifications and cancer
- Microscopic Colitis
- Pain Mechanisms and Treatments
- Biomedical Text Mining and Ontologies
- Biochemical effects in animals
University of Palermo
2016-2025
Plant-derived nanovesicles (PDNVs) have recently emerged as natural delivery systems of biofunctional compounds toward mammalian cells. Considering their already described composition, anti-inflammatory properties, stability, and low toxicity, PDNVs offer a promising path for developing new preventive strategies several inflammatory diseases, among which the bowel disease (IBD). In this study, we explore protective effects industrially produced lemon vesicles (iLNVs) in rat model IBD....
Metabolic Syndrome (MetS) is an extremely complex disease. A non-balanced diet such as high-fat (HFD) induces metabolic dysfunction that could modify redox homeostasis. We here aimed at exploring homeostasis in male Wistar rats, following 8 weeks of HFD, correlating the eventual modification selected biomarkers be associated with clinical manifestations MetS. Therefore, we parameters relative to both glucose tolerance and lipid altered metabolism, but also oxidative pattern. assessed some...
Cystic Fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, coding for chloride channel. About 10% of gene are “stop” that generate a premature termination codon (PTC), thus synthesizing truncated protein. A way to bypass PTC relies on ribosome readthrough, which ribosome’s capacity skip PTC, generating full-length “TRIDs” molecules exerting readthrough; some, mechanism action still under debate. We investigate possible (MOA) our recently synthesized...
This study analysed the contribution of purinergic system to enteric neurotransmission in longitudinal muscle mouse distal colon.Motor responses exogenous ATP and nerve stimulation vitro were assessed as changes isometric tension.ATP induced a concentration-dependent contraction, reduced by 4-[[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzene disulphonic acid (PPADS), suramin, P2Y purinoreceptor desensitisation with adenosine 5'-O-2-thiodiphosphate...
The first record of the red swamp crayfish in Sicily dates back to 2003 and, since then, species seemed be confined a few localities western Sicily. A small "citizen science" project carried out from November 2016 onwards led creation "Sicilian Procambarus working group" (SPwg), which aims at monitoring distribution and impact To date, SPwg found five new sites on island, thus doubling number local occurrence. clarkii lie different river basins, some them located several hundred kilometres...
Stop mutations cause 11% of the genetic diseases, due to introduction a premature termination codon (PTC) in mRNA, followed by production truncated protein. A promising therapeutic approach is suppression therapy Translational Readthrough Inducing Drugs (TRIDs), restoring expression Recently, three new TRIDs (NV848, NV914, NV930) have been proposed, and validated several vitro assays, for rescue CFTR protein, involved Cystic Fibrosis disease. In this work, an acute toxicological study was...
The aims of the present study were firstly, to characterize pharmacologically subtypes P(1) purinoreceptors involved in inhibitory effects induced by exogenous adenosine longitudinal smooth muscle mouse colon, and secondly, examine differences function distribution these receptors between proximal distal colon. Adenosine (100 microM-3 mM) caused a concentration-dependent reduction amplitude spontaneous contractions muscular relaxation In antagonized selective A(1) receptor antagonist,...
Background and purpose: Although it is well accepted that cannabinoids modulate intestinal motility by reducing cholinergic neurotransmission mediated CB 1 receptors, not known whether the endocannabinoids are involved in more complex circuits if they interact with other systems. The aim of present study was to examine possible interactions between cannabinoid receptors purines control spontaneous contractility longitudinal muscle mouse ileum. Experimental approach: mechanical activity...