A5080254567- Metabolism, Diabetes, and Cancer
- Plant biochemistry and biosynthesis
- Plant Gene Expression Analysis
- Photosynthetic Processes and Mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Plant Stress Responses and Tolerance
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Traditional Chinese Medicine Analysis
- Complex Network Analysis Techniques
- COVID-19 epidemiological studies
- Mathematical and Theoretical Epidemiology and Ecology Models
- Peroxisome Proliferator-Activated Receptors
- Muscle metabolism and nutrition
- Biofuel production and bioconversion
- Catalysis for Biomass Conversion
- GABA and Rice Research
- Enzyme Catalysis and Immobilization
- Evolutionary Game Theory and Cooperation
- Cancer, Hypoxia, and Metabolism
- Plant responses to water stress
- Plant nutrient uptake and metabolism
- Plant Molecular Biology Research
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
Institute of Bast Fiber Crops
2025
Chinese Academy of Agricultural Sciences
2025
Ministry of Agriculture and Rural Affairs
2025
Hebei University of Engineering
2018-2024
Tiangong University
2024
Chongqing University of Technology
2019-2023
Beijing University of Civil Engineering and Architecture
2022
Chongqing University
2021
Bioengineering Center
2021
Shaanxi Normal University
2013-2018
Abstract Jasmonates (JAs) are plant-specific key signaling molecules that respond to various stimuli and involved in the synthesis of secondary metabolites. However, little is known about JA signal pathway, especially economically significant medicinal plants. To determine functions novel genes participate JA-mediated accumulation metabolites, we examined metabolomic transcriptomic signatures from Salvia miltiorrhiza . For metabolome, 35 representative metabolites showing changes rates were...
Transcription factors that include myeloblastosis (MYB), basic helix-loop-helix (bHLH), and tryptophan-aspartic acid (WD)-repeat protein often form a ternary complex to regulate the phenylpropanoid pathway. However, only few MYB bHLH members involved in biosynthesis of salvianolic B (Sal B) have been reported, little is known about Sal pathway regulation by WD40 transparent testa glabra 1 (TTG1)-dependent transcriptional complexes Salvia miltiorrhiza. We isolated SmTTG1 from species for...
Studies have indicated that Na+-d-glucose co-transporter (SGLT) inhibitors had anti-proliferative activity by attenuating the uptake of glucose in several tumor cell lines. In this study, molecular docking showed that, trilobatin, one dihydrochalcones from leaves Lithocarpus polystachyus Rehd., might be a novel inhibitor SGLT1 and SGLT2, which evidently attenuated vitro vivo. To our surprise, we observed trilobatin did not inhibit, but promoted proliferation human hepatoblastoma HepG2 Huh 7...
Trilobatin, a natural compound, has been found to exhibit anti-diabetic properties in high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetic mice. But up now no research reported on the effect of trilobatin insulin resistance peripheral tissues. Herein, we determined effects palmitate-treated C2C12 myotubes ob/ob mice.Male mice (8-10 weeks) same background C57BL/6 were used evaluate role resistance; protein expression phosphorylation measured by western blot; glucose uptake was...
Phenolic acids from Salvia miltiorrhiza have drawn considerable attention in recent years because of their remarkable pharmacological activities. We previously reported that Arabidopsis thaliana transcription factor production anthocyanin pigment 1 (AtPAP1) has strong capability to promote the phenolic S. miltiorrhiza. However, responsible molecular mechanism is unclear. Here, we analyzed transcriptome transgenic over-expressed AtPAP1. Transcriptome analysis revealed 4152 genes were...
Environmental stresses such as salt and drought severely affect plant growth development. SQUAMOSA-promoter binding protein-like (SPL) transcription factors (TFs) play critical roles in the regulation of diverse processes; however, reports describing SPL responses to abiotic stress are relatively few. In this study, two stress-responsive TFs from Codonopsis pilosula (CpSPL5 CpSPL8) reported, which confer sensitivity. CpSPL5 CpSPL8 expressed almost all tissues localized nucleus, where...
Abstract Background: Trilobatin, a natural compound, has been found to exhibit anti-diabetic properties in high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetic mice. But up now no research reported on the effect of trilobatin insulin resistance peripheral tissues. Herein, we determined effects palmitate-treated C2C12 myotubes ob/ob Methods: 8-10 weeks male mice same background C57BL/6 were used evaluate role resistance; Protein expression phosphorylation measured by western...
Abstract Background: Trilobatin, a natural compound, has been found to exhibit anti-diabetic properties in high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetic mice. But up now no research reported on the effect of trilobatin insulin resistance peripheral tissues. Herein, we determined effects palmitate-treated C2C12 myotubes ob/ob Methods: 8-10 weeks male mice same background C57BL/6 were used evaluate role resistance; Protein expression phosphorylation measured by western...
Abstract Fatty acid binding protein 4 (FABP4) is predominantly expressed in adipose tissue and functions as an important mediator of inflammation. However, small molecules that regulate the expression FABP4 adipocytes have not been well characterized. In this work, we found that, together with decreasing mRNA secretion proinflammatory cytokines, including tumor necrosis factor α (TNFα) interleukin -6 (IL-6). Treatment trilobatin dose-dependently attenuated levels lipopolysaccharide...
Free fatty acids induce the development of obesity by mediating demethylation fructose 1,6-biphosphatase 2 gene promoters.