A5015120310- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Platelet Disorders and Treatments
- Pharmacogenetics and Drug Metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood donation and transfusion practices
- Hemostasis and retained surgical items
- Eicosanoids and Hypertension Pharmacology
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
- Blood properties and coagulation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- HIV/AIDS drug development and treatment
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- Health Systems, Economic Evaluations, Quality of Life
- Glycosylation and Glycoproteins Research
- Respiratory viral infections research
- Cancer Cells and Metastasis
- Protein Tyrosine Phosphatases
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
University of Milan
2003-2023
Alessandro Manzoni Hospital
2009-2022
Aziende Socio Sanitarie Territoriali di Lecco
2021
Ospedale Maggiore
2005-2011
Hospital Universitario de Canarias
2007-2011
Sapienza University of Rome
2011
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2004-2011
Inserm
2011
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2011
Istituti di Ricovero e Cura a Carattere Scientifico
2008-2010
Chronic infection with the hepatitis delta virus (HDV) is a risk factor for cirrhosis and hepatocellular carcinoma (HCC), but little known whether outcome of predicted by serum markers HDV B (HBV) infection. The aim study was to investigate these correlations in 193 patients chronic who had been followed up median 9.5 years (4.8-19.3). HDV-RNA first measured qualitative in-house nested RT-PCR quantified real-time PCR. RNA levels only appeared significantly associated HCC (univariate...
Objective Variant alleles of the CYP2C9 gene encoding cytochrome P450 (CYP) enzyme ( 2C9*2 [Arg144Cys] and 2C9*3 [Ile359Leu]) are known to increase anticoagulant effect warfarin decrease mean daily dose required maintain international normalized ratio (INR) prothrombin time within target therapeutic range. However, little information is available on polymorphisms requirements during most critical step therapy, induction phase. Methods This retrospective study evaluated dosages given 125...
Abstract: The complete blood counts (CBCs) and the differential leukocyte count are among most requested laboratory tests. These tests frequently performed quickly using highly automated system. modern hematological analyzers easy to use can process several samples in a short period of time (e.g., 120 samples/h). Usually, these used for carrying out cell analysis. However, when instrument flags an important outlier value, morphological study with optical microscopy is carried out....
Background and Aims Increasing evidence that a number of malignancies are characterised by tumour cell heterogeneity has recently been published, but there is still lack data concerning liver cancers. The aim this study was to investigate characterise tumour-propagating (TPC) compartments within human hepatocellular carcinoma (HCC). Methods After long-term culture, we identified three morphologically different populations in single HCC specimen, extensively them means flow cytometry,...
<h3>Objective</h3> Sialic-acid-binding immunoglobulin-like lectin-7 (Siglec-7) is a natural killer (NK) cell inhibitory receptor associated with NK phenotypic and functional abnormalities in HIV-1 infection. We investigated the significance of NK-expressed serum soluble Siglec-7 relation to ability parameters liver necroinflammation fibrosis chronic HCV <h3>Design</h3> were evaluated 130 166 HCV-infected individuals by flow cytometry ELISA, respectively. degranulation cytokine secretion...
The aim of this case-control study was to analyse the prevalence gynaecological, obstetrical and other more general bleeding symptoms in 114 women affected by various inherited disorders, who were compared with apparently healthy women. Retrospective information collected means two specific questionnaires, one on gynaecological symptoms, special focus presence menorrhagia as defined a pictorial blood loss assessment chart (PBAC); whose severity graded score (BS). Compared normal women, whole...
Background: In this study, we aimed to investigate the pathological alterations of LDL-cholesterol, HDL-cholesterol, total cholesterol and triglycerides in COVID-19 patients during acute phase infection, after recovery. Methods: A retrospective study was performed examine serum levels on 55 who were hospitalized our center between February April 2020. The lipid profile hematological parameters analyzed same group before (Group before) clinical management after). laboratory tests results...
Abstract Objectives The aim of the study was to evaluate predictive value cell population data (CPD) parameters in comparison with procalcitonin (PCT) and C-reactive protein (CRP) for an early diagnosis sepsis intensive care unit (ICU). effect renal function on CPD, PCT CRP, septic non-septic patients also investigated. Methods This is a retrospective, observational single-center study, performed collected from consecutively admitted ICU Edoardo Bassini Hospital Milan. Patients were divided...
Anticoagulants of the coumarin type are effective drugs for treatment and prevention thromboembolic diseases. However, they have a narrow therapeutic range show inter- intra-individual variability in dose requirement, largely conditioned by both environmental genetic factors.This prospective study investigated, during initial phase acenocoumarol therapy, effect CYP2C9 variant alleles VKORC1 haplotypes, single combination, 220 Italians.CYP2C9*3 was associated with 25% reduction an increased...
BACKGROUND: Nucleic acid testing (NAT)‐based methods for the detection and quantification of human immunodeficiency virus Type 1 (HIV‐1) RNA are used to increase transfusion safety diagnose manage HIV‐1‐infected patients. We describe a novel HIV‐1 recombinant form associated with lack reactivity or substantial underestimation viral load by commercial NAT assays. STUDY DESIGN AND METHODS: observed repeat blood donor seroconverting anti‐HIV in whom HIV was initially undetectable routine...