A5060420956- Luminescence and Fluorescent Materials
- Lipid Membrane Structure and Behavior
- Porphyrin and Phthalocyanine Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Electrochemical sensors and biosensors
- Conducting polymers and applications
- Advanced battery technologies research
- Electrochemical Analysis and Applications
- Organic Light-Emitting Diodes Research
- Antioxidant Activity and Oxidative Stress
- Molecular Sensors and Ion Detection
- Electrocatalysts for Energy Conversion
- Biochemical and Structural Characterization
- Algal biology and biofuel production
- Spectroscopy and Quantum Chemical Studies
- Insect and Pesticide Research
- Nanopore and Nanochannel Transport Studies
- Advanced Sensor and Energy Harvesting Materials
- Ion channel regulation and function
- Nanoplatforms for cancer theranostics
- Antimicrobial Peptides and Activities
- Perovskite Materials and Applications
- Research on Leishmaniasis Studies
- Bee Products Chemical Analysis
Dublin City University
2020-2024
Central Electrochemical Research Institute
2017-2019
Centre For Environment Architecture & Human Settlements
2017
Contemporary devices for glucose monitoring predominantly rely on finger-pricked blood through an enzyme-catalyzed reaction. However, the enzymes are highly expensive, unstable, and require complex procedures integration with sensing matrix, rendering strategic replacement by nonenzymatic sensors. Here, a sensor is developed based surface engineering of laser scribed graphene (LSG)—an immerging 3D patterned graphene—that combines binder-free, porous, conducting graphitic carbon network. An...
Synergistic effect of a β-Co(OH)<sub>2</sub>–CoO hybrid in enhancing the electrocatalytic activity for water oxidation.
Covalent functionalisation with alkyl tails is a common method for supporting molecular catalysts and photosensitisers onto lipid bilayers, but the influence of chain length on photocatalytic performances resulting liposomes not well understood. In this work, we first prepared series rhenium-based CO2 -reduction [Re(4,4'-(Cn H2n+1 )2 -bpy)(CO)3 Cl] (ReCn ; 4,4'-(Cn -bpy=4,4'-dialkyl-2,2'-bipyridine) ruthenium-based [Ru(bpy)2 (4,4'-(Cn -bpy)](PF6 (RuCn ) different lengths (n=0, 9, 12, 15, 17,...
BODIPY heterochromophores, asymmetrically substituted with perylene and/or iodine at the 2 and 6 positions were prepared investigated as sensitizers for triplet-triplet annihilation up conversion (TTA-UC). Single-crystal X-ray crystallographic analyses show that torsion angle between units lie 73.54 74.51, though they are not orthogonal. Both compounds intense, charge transfer absorption emission profiles, confirmed by resonance Raman spectroscopy consistent DFT calculations. The quantum...
Antimicrobial peptides (AMPs) offer significant hope in the fight against antibiotic resistance. Operating via a mechanism different from that of antibiotics, they target microbial membrane and ideally should damage it without impacting mammalian cells. Here, interactions two AMPs, magainin 2 PGLa, their synergistic effects on bacterial models were studied using electrochemical impedance spectroscopy, atomic force microscopy (AFM), fluorescence correlation spectroscopy. Toroidal pore...
Quinacrine is a versatile drug that widely recognized for its antimalarial action through inhibition of the phospholipase enzyme. It also has antianthelmintic and antiprotozoan activities strong DNA binder may be used to combat multidrug resistance in cancer. Despite extensive cell-based studies, detailed understanding quinacrine's influence on cell membrane, including permeability, binding, rearrangement at molecular level, lacking. Herein, we apply microcavity-suspended lipid bilayers...
Abstract Astaxanthin (AXT) is a lipophilic antioxidant and anti-inflammatory natural pigment whose cellular uptake bioavailability could be improved via liposomal encapsulation. Endothelial cells (EC) line the lumen of all blood vessels are tasked with multiple roles toward maintaining cardiovascular homeostasis. dysfunction linked to development many diseases closely interconnected oxidative stress vascular inflammation. The free AXT into EC was investigated using Raman fluorescence...
Triplet–triplet annihilation upconversion (TTAUC) is an emerging technology in photonics with significant potential impacting a variety of fields (e.g., solar cells, bioimaging, and drug delivery) due to its ability convert long-wavelength photons higher photon energies even at low excitation power densities. However, for many practical applications TTAUC, the transfer system, consisting molecular sensitizer annihilator, from solution, which efficient TTAUC systems have been reported, solid...
Abstract Miltefosine an alkylphosphocholine analogue, is the only drug taken orally for treatment of leishmaniasis‐a parasitic disease caused by sandflies. Although it believed that exerts its activity acting at lipid membrane, detailed understanding interaction this with eukaryotic membranes still lacking. Herein, we exploit microcavity pore suspended bilayers (MSLBs) as a biomimetic platform in combination highly sensitive label‐free electrochemical impedance spectroscopy (EIS) technique...
The antidepressant drug imipramine, and its metabolite desipramine show different extents of interaction with, passive permeation through, cellular membrane models, with the effects depending on composition. Through multimodal interrogation, we can observe that drugs have a direct impact physicochemical properties membrane, may play role in their pharmacokinetics.
Abstract BODIPY‐perylene dyads have emerged as useful metal free sensitizers for triplet‐triplet annihilation upconversion (TTAUC), these are capable of efficient triplet generation via spin‐orbit charge transfer intersystem crossing (SOCT‐ISC). This important route to formation requires in which two moieties oriented perpendicular each other. In this contribution, we give a deeper insight on the behavior recently reported dyads, where dihedral exhibits non‐orthogonal dyad geometry. The with...
Abstract BODIPY and BODIPY‐derived systems are widely applied as fluorophores probes for viscosity detection in solvents biological media. Their orientational rotational dynamics media thus of vital mechanistic importance extensively investigated. In this contribution, polarization‐resolved confocal microscopy is used to determine the orientation an amphiphilic BODIPY‐cholesterol derivative homogeneous giant unilamellar vesicles (GUV) made from 1,2‐dioleoyl‐sn‐glycero‐3‐phosphocholine...
Triplet–triplet annihilation upconversion (TTA-UC) implemented in nanoparticle assemblies is of emerging interest biomedical applications, including drug delivery and imaging. As it a bimolecular process, ensuring sufficient mobility the sensitizer annihilator to facilitate effective collision key. Liposomes can provide benefits two-dimensional confinement condensed concentration along with superior fluidity compared other assemblies. They are also biocompatible widely applied across...