A5056861212- Luminescence and Fluorescent Materials
- bioluminescence and chemiluminescence research
- Metabolomics and Mass Spectrometry Studies
- Fatty Acid Research and Health
- Molecular Sensors and Ion Detection
- Photodynamic Therapy Research Studies
- Photoreceptor and optogenetics research
- Isotope Analysis in Ecology
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Marine Bivalve and Aquaculture Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Meat and Animal Product Quality
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Lanthanide and Transition Metal Complexes
- Eicosanoids and Hypertension Pharmacology
- Luminescence Properties of Advanced Materials
- Infant Nutrition and Health
- Chalcogenide Semiconductor Thin Films
- Analytical Chemistry and Sensors
- Mass Spectrometry Techniques and Applications
- Perovskite Materials and Applications
- Veterinary Equine Medical Research
Sun Yat-sen University
2023-2025
University of Sheffield
2024-2025
Leibniz Institute of Photonic Technology
2021-2024
Friedrich Schiller University Jena
2021-2023
Helmholtz Institute Jena
2021-2023
Institute of Physical Chemistry
2021
Omega-3 long-chain polyunsaturated fatty acids (LCPUFA) play critical roles in human development and health. Their intake is often effectively estimated solely based on seafood consumption, though the high of terrestrial animal-based foods with minor amounts LCPUFA may be significant. Covalent adduct chemical ionization (CACI) tandem mass spectrometry one approach for de novo structural quantitative analysis unsaturated (FA), which standards are unavailable. Here, CACI-MS MS/MS used to...
BODIPY heterochromophores, asymmetrically substituted with perylene and/or iodine at the 2 and 6 positions were prepared investigated as sensitizers for triplet-triplet annihilation up conversion (TTA-UC). Single-crystal X-ray crystallographic analyses show that torsion angle between units lie 73.54 74.51, though they are not orthogonal. Both compounds intense, charge transfer absorption emission profiles, confirmed by resonance Raman spectroscopy consistent DFT calculations. The quantum...
Abstract This study employs TLD1433, a Ru II ‐based photodynamic therapy (PDT) agent in human clinical trials, as benchmark to establish protocols for studying the excited‐state dynamics of photosensitizers (PSs) cellulo , local environment provided by cancer cells. Very little is known about properties any PS live cells, and it terra incognita . contribution targets general problem phototherapy, which how interrogate light‐triggered, function‐determining processes PSs relevant biological...
The biological functions of fatty acids and the lipids in which they are esterified determined by their chain length, double bond position geometry other structural motifs such as presence methyl branches. Unusual isomeric features human foods conjugated bonds or branching found dairy products, some seeds nuts, marine potentially have important effects on health. Recent advancements identifying with unusual positions pinpointing branches empowered study functions. We present recent advances...
We fabricate a type of back-contact perovskite solar cell based on 1.5 μm-width grooves that are embossed into plastic film whose opposing "walls" selectively coated with either n- or p-type contacts. A precursor solution is then deposited the grooves, creating individual photovoltaic devices. Each groove device series-connected to its neighbors, minimodules consisting hundreds connected grooves. Here, we report fabrication groove-based devices using slot-die coating deposit and explore...
The complex fatty acid (FA) composition of the edible portion American oysters (Crassostrea virginica) presents a significant analytical challenge to complete characterization. Here, we employed solvent-mediated covalent adduct chemical ionization enable comprehensive de novo characterization its FA composition, with isotope ratio mass spectrometry for initial measurements 13C signatures. Unusual polymethylene-interrupted (PMI) polyunsaturates were unequivocally identified, 22:2(7Z,15Z)...
Derivatization of unsaturated fatty acids with dimethyl disulfide (DMDS) and analysis by electron ionization mass spectrometry (EIMS) represent a convenient offline method for the identification double bond positions. However, presence overlapping spectra from multiple compounds poses significant challenges spectral interpretation library matching, leading to ambiguous molecular information low sensitivity. To overcome issue, we developed novel chemical (CI) tandem involving...
Sebum fatty acids and squalene are major components of skin secretions play a critical role in the pathogenesis dermatological conditions through their compositional alterations. Human sebum uniquely diverse chain length, double bond positions, branching; is rare component with six bonds. We introduce facile workflow for analysis elucidating contribution to state health or disease using advanced mass spectrometric methods qualitative quantitative analyses. from dermatologically healthy...
BODIPY-based donor-acceptor dyads are widely used as sensors and probes in life science. Thus, their biophysical properties well established solution, while photophysical cellulo, i. e., the environment, which dyes designed to function, generally understood less. To address this issue, we present a sub-ns time-resolved transient absorption study of excited-state dynamics BODIPY-perylene dyad twisted intramolecular charge transfer (TICT) probe local viscosity live cells.
TLD1433 is the first ruthenium (Ru)-based photodynamic therapy (PDT) agent to advance clinical trials and currently in a phase II study for treating nonmuscle bladder cancer with PDT. Herein, we present photophysical of its derivative TLD1633 using complex, biologically relevant solvents elucidate excited-state properties that are key biological activity. The complexes incorporate an imidazo [4,5-f][1,10]phenanthroline (IP) ligand appended α-ter- or quaterthiophene, respectively, where =...
Small molecules are frequently used as dyes, labels and markers to visualize probe biophysical processes within cells.
Two four-coordinate organoboron N,C-chelate complexes with different functional terminals on the PEG chains are studied respect to their photophysical properties within human MCF-7 cells. Their excited-state characterized by time-resolved pump-probe spectroscopy and fluorescence lifetime microscopy. The relaxation dynamics of two similar when in DMSO. Aggregation carboxylate terminal group is observed water. When studying light-driven both cellulo, i. e., after being taken up into cells,...
Abstract BODIPY‐perylene dyads have emerged as useful metal free sensitizers for triplet‐triplet annihilation upconversion (TTAUC), these are capable of efficient triplet generation via spin‐orbit charge transfer intersystem crossing (SOCT‐ISC). This important route to formation requires in which two moieties oriented perpendicular each other. In this contribution, we give a deeper insight on the behavior recently reported dyads, where dihedral exhibits non‐orthogonal dyad geometry. The with...
Abstract This study employs TLD1433, a Ru II ‐based photodynamic therapy (PDT) agent in human clinical trials, as benchmark to establish protocols for studying the excited‐state dynamics of photosensitizers (PSs) cellulo , local environment provided by cancer cells. Very little is known about properties any PS live cells, and it terra incognita . contribution targets general problem phototherapy, which how interrogate light‐triggered, function‐determining processes PSs relevant biological...
Triplet–triplet annihilation upconversion is a bimolecular process converting low-energy photons into high-energy photons. Here, we report calcium-sensing system working via triplet–triplet (TTA) upconverted emission. The probe itself was obtained by covalent conjugation of blue emitter, perylene, with calcium-chelating moiety, and it sensitized the red-light-absorbing photosensitizer palladium(II) tetraphenyltetrabenzoporphyrin (PdTPTBP). Sensing selective for Ca2+ occurred in micromolar...
Abstract Branched‐chain fatty acids (BCFAs) are mostly saturated with a methyl branch at the penultimate or antepenultimate position to CH 3 end. Very‐long‐chain BCFAs (C ≥ 20) uniquely found in surface lipids. Human and California sea lion ( Zalophus californianus ) only two species that possess vernix birth, particles carry loads of BCFA gut, potentially influencing establishment first microbiota. Horse Equus caballus contains high levels its lipids, current study aims investigate if...
Triplet-triplet annihilation upconversion is a bimolecular process converting low-energy light into high-energy one. All available calcium probes, despite their qualities, are downconverting, which leads to the autofluorescence caused by background emission of intra- and intercellular molecules. Here we report calcium-sensing system working via upconverted emission. The probe itself was obtained covalent conjugation perylene blue emitter with calcium-chelating moiety; it sensitized red-light...