A5069829876- dental development and anomalies
- melanin and skin pigmentation
- Cancer-related gene regulation
- Genetic diversity and population structure
- Silkworms and Sericulture Research
- Lipid Membrane Structure and Behavior
- Genetic and phenotypic traits in livestock
- Animal Nutrition and Physiology
- Cellular transport and secretion
- Lysosomal Storage Disorders Research
- Periodontal Regeneration and Treatments
- Biochemical Analysis and Sensing Techniques
- Cleft Lip and Palate Research
University of Washington
2022-2024
University of California, Berkeley
2020-2023
University of Utah
2018
Birds and other vertebrates display stunning variation in pigmentation patterning, yet the genes controlling this diversity remain largely unknown. Rock pigeons (Columba livia) are fundamentally one of four color pattern phenotypes, decreasing order melanism: T-check, checker, bar (ancestral), or barless. Using whole-genome scans, we identified NDP as a candidate gene for variation. Allele-specific expression differences indicate cis-regulatory divergence between ancestral melanistic...
Organ initiation is often driven by extracellular signals that activate precursor cells competent to receive and respond the signal, yet little known about how dynamic competency in space time during development. Teeth are excellent organs study organ because they can be activated with addition of a single signaling ligand, Ectodysplasin (Eda). Eda, Tumor Necrosis Factor (TNF) critical regulator ectodermal development, including teeth, acting through TNF receptors, like Edar, NF-κB tooth...
Abstract Background Vertebrate teeth exhibit a wide range of regenerative systems. Many species, including most mammals, reptiles, and amphibians, form replacement at histologically distinct location called the successional dental lamina, while other species do not employ such system. Notably, ‘lamina-less’ tooth condition is found in paraphyletic array ray-finned fishes, as stickleback, trout, cod, medaka, bichir. Furthermore, position, renewal potential, latency times appear to vary...
SM proteins including Sly1 are essential cofactors of SNARE-mediated membrane fusion. Using SNARE and mutants chemically defined in vitro assays, we separate assess proposed mechanisms through which augments fusion: (i) opening the closed conformation Qa-SNARE Sed5; (ii) close-range tethering vesicles to target organelles, mediated by Sly1-specific regulatory loop; (iii) nucleation productive trans-SNARE complexes. We show that all three important operate parallel, promotes trans-complex...
Most vertebrate species undergo tooth replacement throughout adult life. This process is marked by the shedding of existing teeth and regeneration organs. However, little known about genetic circuitry regulating replacement. Here, we tested whether fish orthologs genes to regulate mammalian hair have effects on Using two that demonstrate distinct modes regeneration, threespine stickleback (Gasterosteus aculeatus) zebrafish (Danio rerio), found transgenic overexpression four different changed...
ABSTRACT Birds and other vertebrates display stunning variation in pigmentation patterning, yet the genes controlling this diversity remain largely unknown. Rock pigeons ( Columba livia ) are fundamentally one of four color pattern phenotypes, decreasing order melanism: T-check, checker, bar (ancestral), or barless. Using whole-genome scans, we identified NDP as a candidate gene for variation. Allele-specific expression differences indicate cis -regulatory between ancestral melanistic...
Abstract Background Vertebrate teeth exhibit a wide range of regenerative systems. Many species, including most mammals, reptiles, and amphibians, form replacement at histologically distinct location called the successional dental lamina, while other species do not employ such system. Notably, ‘lamina-less’ tooth condition is found in paraphyletic array ray-finned fishes, as stickleback, trout, cod, medaka, bichir. Furthermore, position, renewal potential, latency times appear to vary...
Abstract Most vertebrate species undergo tooth replacement throughout adult life. This process is marked by the shedding of existing teeth and regeneration organs. However, little known about genetic circuitry regulating replacement. Here we tested whether fish orthologs genes to regulate mammalian hair have effects on Using two that demonstrate distinct modes regeneration, threespine stickleback ( Gasterosteus aculeatus ) zebrafish Danio rerio ), found transgenic overexpression four...