A5080044216- Genetic diversity and population structure
- melanin and skin pigmentation
- Genetic and phenotypic traits in livestock
- Animal Behavior and Reproduction
- Chromosomal and Genetic Variations
- Plant Reproductive Biology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Marine Invertebrate Physiology and Ecology
- Lymphoma Diagnosis and Treatment
- Silk-based biomaterials and applications
- Protist diversity and phylogeny
- Plant Molecular Biology Research
- Photoreceptor and optogenetics research
- Identification and Quantification in Food
- Silkworms and Sericulture Research
- Genomics and Chromatin Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Echinoderm biology and ecology
- Plant and Biological Electrophysiology Studies
- Biochemical Analysis and Sensing Techniques
- Animal Nutrition and Physiology
- HER2/EGFR in Cancer Research
University of Utah
2016-2021
Luxel (United States)
2014
University of Washington
2014
Seagen (United States)
2014
The origins of neural systems remain unresolved. In contrast to other basal metazoans, ctenophores (comb jellies) have both complex nervous and mesoderm-derived muscular systems. These holoplanktonic predators also sophisticated ciliated locomotion, behaviour distinct development. Here we present the draft genome Pleurobrachia bachei, Pacific sea gooseberry, together with ten ctenophore transcriptomes, show that they are remarkably from animal genomes in their content neurogenic, immune...
Birds display remarkable diversity in the distribution and morphology of scales feathers on their feet, yet genetic developmental mechanisms governing this remain unknown. Domestic pigeons have striking variation foot feathering within a single species, providing tractable model to investigate molecular basis skin appendage differences. We found that feathered feet result from partial transformation hindlimb forelimb identity mediated by cis-regulatory changes genes encoding...
Birds and other vertebrates display stunning variation in pigmentation patterning, yet the genes controlling this diversity remain largely unknown. Rock pigeons (Columba livia) are fundamentally one of four color pattern phenotypes, decreasing order melanism: T-check, checker, bar (ancestral), or barless. Using whole-genome scans, we identified NDP as a candidate gene for variation. Allele-specific expression differences indicate cis-regulatory divergence between ancestral melanistic...
Rock pigeons (Columba livia) display an extraordinary array of pigment pattern variation. One such pattern, Almond, is characterized by a variegated patchwork plumage colors that are distributed in apparently random manner. Almond sex-linked, semi-dominant trait controlled the classical Stipper (St) locus. Heterozygous males (ZStZ+ sex chromosomes) and hemizygous females (ZStW) favored breeders for their attractive plumage. In contrast, homozygous (ZStZSt) develop severe eye defects often...
Abstract The iris of the eye shows striking color variation across vertebrate species, and may play important roles in crypsis communication. domestic pigeon (Columba livia) has three common colors, orange, pearl (white), bull (dark brown), segregating a single thereby providing unique opportunity to identify genetic basis coloration. We used comparative genomics mapping laboratory crosses two candidate genes that control pigeons. identified nonsense mutation solute carrier SLC2A11B is...
Abstract SGN-35 (cAC10-vcMMAE, brentuximab vedotin) is an auristatin antibody-drug conjugate (ADC), which targets CD30, for the treatment of relapsed Hodgkin lymphoma (HL) and systemic anaplastic large cell (ALCL). We developed three resistant (BVR) line models to identify mechanisms by HL ALCL cells may become therapy. Resistant DEL Karpas-299 (ALCL) L540cy lines were generated continuous exposure increasing dose levels over time. BVR with >10-fold decrease in sensitivity versus...
ABSTRACT The iris of the eye shows striking color variation across vertebrate species, and may play important roles in crypsis communication. domestic pigeon ( Columba livia) has three common colors, orange, pearl (white), bull (dark brown), segregating a single thereby providing unique opportunity to identify genetic basis coloration. We used comparative genomics mapping laboratory crosses two candidate genes that control pigeons. identified nonsense mutation solute carrier SLC2A11B is...
ABSTRACT Birds and other vertebrates display stunning variation in pigmentation patterning, yet the genes controlling this diversity remain largely unknown. Rock pigeons ( Columba livia ) are fundamentally one of four color pattern phenotypes, decreasing order melanism: T-check, checker, bar (ancestral), or barless. Using whole-genome scans, we identified NDP as a candidate gene for variation. Allele-specific expression differences indicate cis -regulatory between ancestral melanistic...
ABSTRACT Rock pigeons ( Columba livia ) display an extraordinary array of pigment pattern variation. One such pattern, Almond, is characterized by a variegated patchwork plumage colors that are distributed in apparently random manner. Almond sex-linked, semi-dominant trait controlled the classical Stipper St locus. Heterozygous males (Z Z + sex chromosomes) and hemizygous females W) favored breeders for their attractive plumage. In contrast, homozygous develop severe eye defects lack all...
Abstract Changes in epidermal pigmentation are associated with eye defects humans and other vertebrates. In the rock pigeon ( Columba livia ), sex-linked Almond color pattern is characterized by hypopigmentation of structures. The trait controlled classical Stipper St ) locus, homozygous Z males often have severe defects. Heterozygous + hemizygous (Z W) pigeons do not typically obvious defects, suggesting that higher dosage mutant allele deleterious. Because pronounced structures, we...