A5052940212- Systemic Lupus Erythematosus Research
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Obesity, Physical Activity, Diet
- Renal Diseases and Glomerulopathies
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Diet and metabolism studies
- Platelet Disorders and Treatments
- Birth, Development, and Health
- Temporomandibular Joint Disorders
- Rheumatoid Arthritis Research and Therapies
- Body Composition Measurement Techniques
- Breastfeeding Practices and Influences
- Nutrition, Health and Food Behavior
- Blood Coagulation and Thrombosis Mechanisms
- Chemokine receptors and signaling
- Nutritional Studies and Diet
- Bone health and osteoporosis research
- Retinoids in leukemia and cellular processes
- Eosinophilic Esophagitis
- Systemic Sclerosis and Related Diseases
- Child Nutrition and Feeding Issues
- Meat and Animal Product Quality
National Center For Child Health and Development
2016-2025
Nuffield Orthopaedic Centre
2022
University of Oxford
2022
Yokohama National University
2000-2017
Tokyo Medical and Dental University
1996-2014
Tokyo Metropolitan University
2006
Higashi Nippon International University
2006
Tokyo Gakugei University
2006
National Institute of Infectious Diseases
2006
Hokkaido University Hospital
1998
Abstract Objectives To update the Japan College of Rheumatology Clinical Practice Guidelines for Management Rheumatoid Arthritis (CPG RA). Methods The recommendations were developed based on evidence published until end June 2022 using Grading Recommendations Assessment, Development, and Evaluation (GRADE). steering committee, CPG panel, systematic review (SR) group, SR support team organised. Results treatment goal drug algorithm required no modifications; however, footnotes modified. 21...
Abstract Introduction Chemerin is a chemotactic agonist identified as ligand for ChemR23 that expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the expression of chemerin in synovium rheumatoid arthritis (RA) patients stimulatory effects fibroblast-like synoviocytes (FLSs) from RA patients. Methods was ascertained by immunohistochemistry Western blot analysis. cultured FLSs ELISA. determined immunocytochemistry Cytokine production measured FLS cell motility...
Abstract We sent questionnaires to the major dermatological institutions in Japan concerning course and associations of dermatomyositis (DM). Of 637 cases observed between 1973 1983, 68 were children. The mortality rate was 2.9% children, 47.1% adult males, 30.0% females. Associations with malignancies noted 30.1% adults; 112 (19.7% adults) died from these, but surgery improved signs DM 22 cases. main neoplasms cancer stomach, lung, colon, breast. Association pulmonary fibrosis (PF) 85...
The interaction between CXCL12 and its receptor, CXCR4, in the synovium of patients with rheumatoid arthritis (RA) is important for local inflammatory cell recruitment, angiogenesis, cytokine production. CXCR7 was recently identified as an alternative receptor CXCL12. We undertook this study to analyze expression RA pathogenic role CXCL12/CXCR7 pathway RA.CXCR7 synovial tissue analyzed using immunohistochemistry, while CXCR4 on human umbilical vein endothelial cells (HUVECs) examined...
Biological drugs are effective in patients with rheumatoid arthritis (RA), but increase severe infections. The CC chemokine receptor (CCR) 9 antagonist was for Crohn's disease without critical adverse effects including infections clinical trials. present study carried out to explore the pathogenic roles of (C-C motif) ligand (CCL) 25 and its receptor, CCR9, autoimmune if CCR9 could be a new treatment RA.CCL25 expression examined immunohistochemistry Western blotting. Concentration...
Abstract Objective: To develop regression‐based equations that estimate physical activity ratios [energy expenditure (EE) per minute/sleeping metabolic rate] for low‐to‐moderate intensity activities using total acceleration obtained by triaxial accelerometry. Research Methods and Procedures: Twenty‐one Japanese adults were fitted with a accelerometer while also in whole‐body human calorimeter 22.5 hours. The protocol time was composed of sleep (8 hours), four structured periods totaling 4...
RNA interference, mediated by small interfering (siRNA), is effective in silencing genes with a high degree of specificity. To explore the therapeutic potential systemically administered siRNA for rheumatoid arthritis (RA), we tested complex and recently developed wrapsome (siRNA/WS) containing siRNA-encapsulated liposome mice collagen-induced (CIA). Mice CIA received an intravenous injection Cy5-labeled siRNA/WS. Fluorescence stereoscopic microscopy flow cytometry were used to assess...
Abstract Background Patients with ulcerative colitis (UC) may be concerned about medication safety during preconception, pregnancy, and lactation, they should closely followed up to ensure that UC activity is controlled the perinatal period. Reported information on of ustekinumab pregnancy lactation limited. In this case report, we examined in a fetus breastfed infant reference drug concentrations maternal serum, cord blood, breast milk, serum. Case presentation A 36-year-old female who...
Abstract Hemophilia B is an X‐linked inherited bleeding disorder characterized by decreased coagulation factor IX levels. Female hemophilia carriers can experience similar to male ones; however, they rarely severe during pregnancy. A 37‐year‐old carrier experienced after a miscarriage. The was initially controlled with transfusion and uterine artery embolization. However, several days, the patient exhibited massive again, which replacement. In her subsequent pregnancy, presented subchorionic...
Objectives To investigate the perceptions and experiences of people with specific immune-mediated inflammatory diseases during process switching from Humira to biosimilar adalimumab. Design Cross-sectional survey. Setting An anonymised, self-administered, web-based Participants The participants were drawn members non-members either National Rheumatoid Arthritis Society, Axial Spondyloarthritis Crohn’s Colitis UK, or Psoriasis Association. Birdshot Uveitis Society Olivia’s Vision also...
Abstract Objective Polymyositis and dermatomyositis are chronic inflammatory muscle diseases. Retinoids compounds that bind to the retinoic acid binding site of receptors have biologic activities similar those vitamin A. Recent studies indicate retinoids promote Th2 differentiation suppress Th1 Th17 in vitro. The present study was undertaken examine effects a synthetic retinoid, Am80, on experimental autoimmune myositis as well Th phenotype development antibody production. Methods...
To investigate the use of tocilizumab (TCZ) in pregnant patients with active rheumatoid arthritis (RA) refractory to anti-tumour necrosis factor (TNF) agents.We retrospectively analysed medical records women RA treated between July 2008 and January 2015 by Division Maternal Medicine at our hospital. Inclusion criteria for this case series included anti-TNF agents exposure TCZ time conception.Our review 28 patient hospital identified four who met inclusion criteria. All had synovitis before...
ABSTRACT Objectives This study aimed to clarify the issues related pregnancy in patients with inflammatory rheumatic diseases (RDs) and provide useful information for developing medical services from patients’ perspectives. Methods A survey involving approximately 5000 members of Patients Association Collagen Vascular Diseases Japan was conducted using a questionnaire that sent returned by mail. The items included age at time survey, types RDs, association RDs pregnancy/childbirth outcomes,...
The effects of sulfur-containing amino acids (SAA) and potassium (K) on urinary excretion retention calcium (Ca) 27 young Japanese women were studied. A basal diet low in protein level (50 g per day) was fortified by meat or soy isolate (SPI) to a 100 day, addition apple these high diets, SAA and/or the SPI diet, especially Ca excretion, which increased intake caused increase apparent absorption with sulfur (S), phosphate, ammonia, titratable (TA), whereas did not. decreased Ca. Urinary Ca,...
Accurate estimation of resting energy expenditure (REE) in children and adolescents is important to establish estimated requirements for the Japanese population. Our objectives were 1) determine REE 6- 17-y-old by indirect calorimetry order estimate this group, 2) compare measured with predicted accuracy predictive equations adolescents, 3) derive new based on REE. was 221 aged 6 17 y old (113 boys 108 girls) using a ventilated calorimeter. Anthropometric body composition measurements also...
To clarify the correlation between preeclampsia and parity to identify protective factors against in multiparous women with systemic lupus erythematosus (SLE).We conducted a single-center, retrospective chart review study of 85 pregnant women. We used multiple logistic regression analysis assess association SLE, described detailed clinical courses management four history severe woman who experienced during her latest pregnancy.Multiparity was significantly associated low risk (adjusted odds...
The present study compared the accuracy of triaxial accelerometry and doubly labelled water (DLW) method for measuring physical activity (PA) in Japanese adolescents. A total sixty adolescents aged 12–15 years were analysed. energy expenditure (TEE) was measured over 7 d by DLW with an EW4800P accelerometer (Panasonic Corporation). (RMR m ) predicted RMR p 5·7 ( sd 0·9) 6·0 1·0) MJ/d, respectively. TEE using or 11·0 2·6), 10·3 1·9), 10·7 2·1) PA levels (PAL) 1·97 0·31) 1·94 subjects who...
Abstract Aims Tocilizumab (TCZ), a humanized anti‐interleukin‐6 receptor monoclonal antibody, is used to treat rheumatic diseases. There limited information about the administration of TCZ during lactation. The dried spot method, simple technique for processing biological samples which involves placement drop specimen onto filter paper, has been in clinical pharmacology determine various drug concentrations. This study examined feasibility sample collection using milk (DMS) method obtaining...
We present two patients with rheumatoid arthritis (RA) who developed necrotizing crescentic glomerulonephritis (NCGN) during etanercept therapy. Both proteinuria and hematuria, one progressed to renal failure. Renal biopsy revealed NCGN. In both patients, nephritis improved following discontinuation of administration prednisolone. Physicians should be aware etanercept-induced GN in RA on anti-tumor necrosis factor
We present two patients with rheumatoid arthritis (RA) who developed necrotizing crescentic glomerulonephritis (NCGN) during etanercept therapy. Both proteinuria and hematuria, one progressed to renal failure. Renal biopsy revealed NCGN. In both patients, nephritis improved following discontinuation of administration prednisolone. Physicians should be aware etanercept-induced GN in RA on anti-tumor necrosis factor