A5042696664- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Systemic Lupus Erythematosus Research
- Pregnancy and preeclampsia studies
- Folate and B Vitamins Research
- Maternal Mental Health During Pregnancy and Postpartum
- Pharmacological Effects and Toxicity Studies
- COVID-19 Impact on Reproduction
- Cardiac Arrhythmias and Treatments
- Lymphoma Diagnosis and Treatment
- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- Mechanical Circulatory Support Devices
- Neonatal Respiratory Health Research
- Breastfeeding Practices and Influences
- Reproductive Health and Contraception
- Multiple and Secondary Primary Cancers
- Cardiovascular Conditions and Treatments
- Genetic and rare skin diseases.
- Salivary Gland Tumors Diagnosis and Treatment
- Papaya Research and Applications
- Maternal and fetal healthcare
- Cardiac and Coronary Surgery Techniques
- Ear and Head Tumors
- Gynecological conditions and treatments
National Center For Child Health and Development
2016-2025
Iwate Medical University
2022
Aso Iizuka Hospital
2017
Showa University Northern Yokohama Hospital
2016
Fukushima Medical University
2007-2014
Nepean Hospital
2007
Sapienza University of Rome
2007
University of Colorado Denver
2007
Kagoshima City Hospital
2004
The University of Tokyo
1989
ABSTRACT Aim Uncontrolled chronic inflammatory diseases (CIDs) before, during, and after pregnancy, as well some CID medications, can increase the risk of impaired fertility in addition to adverse maternal/pregnancy outcomes women childbearing age. We report pregnancy from prospectively reported pregnancies Japanese treated with certolizumab pegol (CZP). Methods Data July 2001 November 2020 on CZP‐exposed CZP Pharmacovigilance safety database were reviewed. Pregnancy analyzed included live...
Abstract Aim To assess the teratogenic risk of domperidone by comparing incidence major malformation with to a control. Methods Pregnancy outcome data were obtained for women at two Japanese facilities that provide counseling on drug use during pregnancy between April 1988 and December 2017. The was calculated among infants born taking ( n = 519), nonteratogenic drugs (control, 1673), or metoclopramide (reference, 241) first trimester pregnancy. Using control group as reference, crude odds...
Objective: To investigate the risk of major congenital malformations associated with exposure to second-generation antipsychotics (SGAs) in first trimester.Methods: Pregnant women who received consultation on drug from Japan Drug Information Institute Pregnancy October 2005 December 2016 were asked complete a questionnaire at 1 month after expected delivery date. The included items pregnancy outcome, date delivery, gestational age infant that confirmed by pediatrician's report, and following...
Abstract Given the paucity of safety data on fluoroquinolone antibiotics in pregnancy, a prospective observational cohort study was conducted pregnant women who sought help and advice drug use at two teratology information institutes Japan. The primary endpoint incidence major congenital anomalies. population included exposed to (i) fluoroquinolones (fluoroquinolone group), (ii) β‐lactams (infectious control or (iii) other agents considered be nonteratogenic humans (nonteratogenic group)...
Recurrent herpes simplex (RHS) is a disease caused by reactivation of the virus. Patients with RHS are treated anti-herpes virus medication. Amenamevir one such medication used for in Japan and administered as patient-initiated therapy (PIT); this involves initiation at discretion patient, based on early symptoms. However, there insufficient data transfer amenamevir into breast milk among breastfeeding patients RHS. This study aims to assess evaluate infant's risk drug exposure. single-arm,...
Ensuring medication safety during pregnancy is crucial for protecting maternal and fetal health. However, fragmented data sources the lack of comprehensive databases present substantial barriers to effective pharmacovigilance. The Japan Drug Information Institute in Pregnancy (JDIIP) database, which contains on drug treatment counseling pregnant women, expected help address pharmacovigilance (PregPV). We evaluated quality utility JDIIP database PregPV activities, particularly its ability...
ABSTRACT Introduction Rheumatoid arthritis (RA) frequently affects women of reproductive age; its treatment requires disease‐modifying antirheumatic drugs (DMARDs). Despite the widespread use biologics and expected improvement in fertility, real‐world studies evaluating outcomes with RA are limited. We aimed to compare without using a nationwide claims database Japan. Methods This retrospective cohort study analyzed 231 427 (aged 20–38 years) from JMDC Claims Database. After propensity score...
To investigate the use of tocilizumab (TCZ) in pregnant patients with active rheumatoid arthritis (RA) refractory to anti-tumour necrosis factor (TNF) agents.We retrospectively analysed medical records women RA treated between July 2008 and January 2015 by Division Maternal Medicine at our hospital. Inclusion criteria for this case series included anti-TNF agents exposure TCZ time conception.Our review 28 patient hospital identified four who met inclusion criteria. All had synovitis before...
Background: Belimumab is a recombinant human immunoglobulin G1 lambda monoclonal antibody that binds soluble B lymphocyte stimulator protein with high affinity and inhibits its biological activity. not recommended for breastfeeding women due to insufficient data about excretion into breast milk. In this study, we measured belimumab concentrations in the milk of one nursing mother diagnosed mixed connective tissue disease (MCTD) evaluated health her breastfed infant. Materials Methods:...
Abstract For leukotriene receptor antagonists (LTRAs), especially pranlukast, safety data during pregnancy is limited. Therefore, we conducted a prospective, two‐centered cohort study using from teratogen information services in Japan to clarify the effects of LTRA exposure on maternal and fetal outcomes. Pregnant women who being counseled drug use at two facilities were enrolled. The primary outcome this was major congenital anomalies. incidence anomalies exposed montelukast or pranlukast...
ABSTRACT Objectives This study aimed to clarify the issues related pregnancy in patients with inflammatory rheumatic diseases (RDs) and provide useful information for developing medical services from patients’ perspectives. Methods A survey involving approximately 5000 members of Patients Association Collagen Vascular Diseases Japan was conducted using a questionnaire that sent returned by mail. The items included age at time survey, types RDs, association RDs pregnancy/childbirth outcomes,...
To assess the risk of major birth defects after first-trimester exposure to carbocisteine and ambroxol during pregnancy, we conducted a prospective cohort study using counseling data for drug use pregnancy provided by Japan Drug Information Institute in Pregnancy Toranomon Hospital. Counseling information, including usage participants' demographic was collected between April 1988 December 2017. outcome data, defects, were obtained questionnaire administered 1 month delivery. The risks (n =...
Abstract Aims Tocilizumab (TCZ), a humanized anti‐interleukin‐6 receptor monoclonal antibody, is used to treat rheumatic diseases. There limited information about the administration of TCZ during lactation. The dried spot method, simple technique for processing biological samples which involves placement drop specimen onto filter paper, has been in clinical pharmacology determine various drug concentrations. This study examined feasibility sample collection using milk (DMS) method obtaining...
Werner syndrome is an autosomal-recessive disease characterized by premature aging, shortness of stature, scleroderma-like skin changes, endocrine abnormalities, and cataracts. Although radiographic findings have been well documented, the presence distinctive osteosclerotic changes in phalanges hands feet has not emphasized previous publications. The authors' review radiographs both nine patients six with documented frequent occurrence phalangeal sclerosis related predominantly to endosteal...
The Japan Drug Information Institute in Pregnancy (JDIIP) was established with the aims of providing information on drug safety to women who are worried about use during pregnancy and creating evidence through epidemiological studies based counseling cases. Since being established, JDIIP has made many contributions wellness mothers children by promoting proper drugs pregnancy. A network consisting Core hospitals 47 prefectures plays an important role for living anywhere Japan. Because cases...
To evaluate the safety of triptan use during pregnancy in a Japanese population, we descriptively analyzed data on and fetal outcomes from 128 pregnant women using triptans for migraine treatment at two facilities that provided counseling drug exposure between 2001 2017. The risks miscarriage, low birth weight, preterm were similar to those reported demographic statistics Japan. incidence proportion malformation was also within baseline risk range. Accumulated suggest does not clearly...
To elucidate clinical feature and anti-phospholipid antibody (aPL) profiles, including lupus anticoagulant (LA), anti-cardiolipin (CL) antibodies anti-phosphatidylserine/prothrombin (PS/PT) antibodies, of pregnancy failure in patients with antiphospholipid syndrome (APS) already treated conventional therapy.Thirty-four women a history who were diagnosed APS between 2008 2016 included the study. We defined successful group as gave birth to healthy baby over 1500 g after 34 weeks under...