A5078130412- Kawasaki Disease and Coronary Complications
- Cardiac Imaging and Diagnostics
- Pharmacovigilance and Adverse Drug Reactions
- Coronary Artery Anomalies
- Respiratory and Cough-Related Research
- Cardiac electrophysiology and arrhythmias
- Tracheal and airway disorders
- Asthma and respiratory diseases
- Medical Imaging Techniques and Applications
- Rheumatoid Arthritis Research and Therapies
- Cardiac Structural Anomalies and Repair
- Phonocardiography and Auscultation Techniques
- Cardiovascular Issues in Pregnancy
- Systemic Lupus Erythematosus Research
- Biosimilars and Bioanalytical Methods
- Drug-Induced Adverse Reactions
- Infective Endocarditis Diagnosis and Management
- Ion channel regulation and function
- Pharmaceutical studies and practices
- Respiratory viral infections research
- Mechanical Circulatory Support Devices
- Patient-Provider Communication in Healthcare
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
Tokai University
2009-2024
Izumo Science Center
2017-2022
Jikei University School of Medicine
2020
Kanagawa Children's Medical Center
2001
Hokkaido University
1997
Osaka University
1996-1997
Niigata University
1987
Few studies with sufficient statistical power have shown the association of z score coronary arterial internal diameter events (CE) in patients Kawasaki disease (KD) artery aneurysms (CAA).To clarify time-dependent CE occurrence KD CAA.This multicenter, collaborative retrospective cohort study 44 participating institutions included 1006 younger than 19 years who received a angiography between 1992 and 2011.The CE, including thrombosis, stenosis, obstruction, acute ischemic events,...
Background Coronary arterial aneurysms (CAAs) associated with Kawasaki disease (KD) significantly affect prognosis. However, the clinical course of CAAs and factors CAA regression have not been well analyzed. Methods Results The cohort Z-Score 2nd Project Stage study, a multicenter, retrospective, study involving 44 institutions in Japan including 1006 patients KD, was examined. were classified by z score their internal diameter acute phase: small (z<5), medium (5≤z<10), large (z≥10). lower...
Attitudes of healthcare professionals regarding spontaneous reporting adverse drug reactions (ADRs) in Japan are not well known, and Japan's unique system surveillance, called early post-marketing phase vigilance (EPPV), may affect these attitudes. Our objectives were to describe potential effects EPPV test whether ADR seriousness, prominence, frequency related changes over time.A manufacturer's database reports was used extract data from individual case safety for 5 drugs subject EPPV. The...
Although several reports have suggested that patient-generated data from Internet sources could be used to improve drug safety and pharmacovigilance, few studies identified such in Japan. We introduce a unique Japanese source: tōbyōki, which translates literally as "an account of struggle with disease."The objective this study was evaluate the basic characteristics TOBYO database, collection tōbyōki blogs on Internet, discuss potential applications for pharmacovigilance.We analyzed overall...
Abstract Objectives To develop a prediction model for serious infections (SIs) in rheumatoid arthritis (RA) patients treated with tocilizumab Japan and to evaluate the model’s performance compared previously developed models, i.e., ‘DANBIO’ ‘postmarketing surveillance’ (PMS). Method This non-interventional retrospective cohort study utilized Medical Data Vision database Japan. The population was derived from ≥ 18 years RA who initiated between April 2008 July 2021. SIs were assessed during...
Ensuring medication safety during pregnancy is crucial for protecting maternal and fetal health. However, fragmented data sources the lack of comprehensive databases present substantial barriers to effective pharmacovigilance. The Japan Drug Information Institute in Pregnancy (JDIIP) database, which contains on drug treatment counseling pregnant women, expected help address pharmacovigilance (PregPV). We evaluated quality utility JDIIP database PregPV activities, particularly its ability...
Stable isotope ratios (
An effort-independent breath sound analysis is expected to be a safe and simple method for clinical assessment of changes in airway function. The effects bronchoconstriction bronchodilation on novel parameters asthmatic children were investigated.The study population included 49 with atopic asthma (male = 33; mean age: 10.2 years). We evaluated the highest frequency power spectrum (HFp), limiting 50% 99% (F50 F99 ) roll-off from 600 Hz HFp (Slope). also assessed new obtained using ratios...
To study risk for cardiovascular disease (CVD) in Japanese patients with rheumatoid arthritis (RA).We used a Medical Data Vision database mainly composed of health insurance claim data and diagnosis-procedure combination from Japan. Patients RA diagnosed April 2011 to March 2014 at 71 hospitals were identified the International Classification Diseases 10th revision (ICD-10) history anti-RA drug prescription. Hospitalizations CVD including ischemic heart disease, failure, stroke by diagnosis...
Oxygen and carbon stable isotope ratios (18O/16O, 13C/12C, 17O/16O) of CO2 have been crucial in helping us understand Earth planetary systems. These also used medicine for the noninvasive diagnosis diseases from exhaled breath quantifying biochemical or metabolic reactions determining production area agricultural products. The current method measuring is primarily gas-source ratio mass spectroscopy (IRMS). Due to recent demand isotopic microanalysis carbonates organic compounds, sample size...
Objective: To search for signs and symptoms before serious infection (SI) occurs in tocilizumab (TCZ)-treated rheumatoid arthritis (RA) patients. Methods: Individual case safety reports, including structured (age, sex, adverse event [AE]) unstructured (clinical narratives) data, were analyzed by automated text mining from a Japanese post-marketing AE-reporting database (16 April 2008–10 2015) assuming the following: treated Japan; TCZ RA treatment; ≥1 SI; unable to exclude causality between...
Measuring patient satisfaction is a crucial aspect of medical care. Advanced natural language processing (NLP) techniques enable the extraction and analysis high-level insights from textual data; nonetheless, data obtained patients are often limited.This study aimed to create model that quantifies based on diverse patient-written data.We constructed neural network-based NLP for this cross-sectional using content disease blogs written in Japanese Internet between 1994 2020. We extracted...
Background Epigenetic silencing of the O6-methylguanine-DNA methyltransferase (MGMT) DNA repair enzyme via promoter hypermethylation (hmMGMT) may increase mutations in TP53 oncosuppressor gene and contribute to carcinogenesis. The effects smoking, which is a risk factor for head neck squamous cell carcinoma (HNSCC), were investigated determine whether they up- or down-regulate hmMGMT. Additionally, impact hmMGMT disruptive TP53-mutations on relapse was patients with HNSCC. Methods This study...
Abstract We encountered a boy with Jervell and Lange-Nielsen syndrome (JLNS) compound heterozygous KCNQ1 mutations, maternal Trp248Phe novel paternal mutation, Leu347Arg. His father showed long QT (LQT) arrhythmia. mother was asymptomatic no ECG abnormalities. The proband his had an additional mutation ( SNTA1 Thr372Met), which is reportedly related to SIDS. These results suggest that multiple gene mutations influence the phenotype of mutation-related
Abstract 3‐Methyl‐5‐nitrobenzofuran ( 2 ) and 3‐methyl‐5‐nitrobenzofuran‐2‐carboxylic acid 3 were obtained by heating 2‐acetyl‐4‐nitrophenoxyacetic 1 with various bases in acetic anhydride. It appeared that 3‐hydroxy‐3‐methyl‐5‐nitro‐2,3‐dihydrobenzofuran‐2‐carboxylic 4 was the intermediate benzofuran synthesis. The properties of examined under conditions. Using strong such as triethyl‐amine place sodium acetate, exclusively. However, presence reaction mixture 3‐methyl‐5‐nitrobenzofuran good...