A5082176189- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Genetic Syndromes and Imprinting
- RNA Research and Splicing
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Hemodynamic Monitoring and Therapy
- Advanced MRI Techniques and Applications
- Cancer-related gene regulation
- Cardiovascular Function and Risk Factors
- Genomics and Rare Diseases
National Heart Lung and Blood Institute
2022-2024
The University of Texas Southwestern Medical Center
2024
Southwestern Medical Center
2024
Framingham Heart Study
2022-2024
Naval Research Laboratory Information Technology Division
2023-2024
National Institutes of Health
2022
Abstract Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which is associated with gene expression. The present study describes an eQTM resource of CpG-transcript pairs derived from whole blood and RNA sequencing expression data in 2115 Framingham Heart Study participants. We identified 70,047 significant cis p < 1E−7 where the top most eGenes (i.e., transcripts a CpG) were enriched biological pathways related to cell signaling, for 1208 clinical...
Abstract To create a scientific resource of expression quantitative trail loci (eQTL), we conducted genome-wide association study (GWAS) using genotypes obtained from whole genome sequencing (WGS) DNA and gene levels RNA (RNA-seq) blood in 2622 participants Framingham Heart Study. We identified 6,778,286 cis -eQTL variant-gene transcript (eGene) pairs at p < 5 × 10 –8 (2,855,111 unique variants 15,982 eGenes) 1,469,754 trans variant-eGene 1e−12 (526,056 7233 eGenes). In addition, 442,379...
DNA methylation commonly occurs at cytosine-phosphate-guanine sites (CpGs) that can serve as biomarkers for many diseases. We analyzed whole genome sequencing data to identify quantitative trait loci (mQTLs) in 4126 Framingham Heart Study participants. Our mQTL mapping identified 94,362,817 cis-mQTLvariant-CpG pairs (for 210,156 unique autosomal CpGs) P < 1e-7 and 33,572,145 trans-mQTL variant-CpG 213,606 1e-14. Using cis-mQTL variants 1258 CpGs associated with seven cardiovascular disease...
Extracellular microRNAs (miRNAs) are a class of noncoding RNAs that remain stable in the extracellular milieu, where they contribute to various physiological and pathological processes by facilitating intercellular signaling. Previous studies have reported associations between miRNAs cardiovascular diseases (CVDs); however, plasma miRNA signatures CVD its risk factors not been fully elucidated at population level.
To create a scientific resource of expression quantitative trail loci (eQTL), we conducted genome-wide association study (GWAS) using genotypes obtained from whole genome sequencing (WGS) DNA and gene levels RNA (RNA-seq) blood in 2622 participants Framingham Heart Study. We identified 6,778,286
Background: In heart failure with preserved ejection fraction (HFpEF) expanded blood volume (BV) can result in significant hemodynamic stress that contributes to disease pathogenesis. Due the lack of routine access methods BV measurement, clinicians typically rely on prediction equations. However, current equations do not accurately or precisely estimate BV, its components, HFpEF. The aim our analysis was directly measure adults HFpEF and compare newly developed (Oberholzer et al ., 2023)...
Background Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which is associated with gene expression and may reveal molecular mechanisms of disease. The present study describes an eQTM resource CpG-transcript pairs. Methods was measured in blood samples from 1,045 Framingham Heart Study (FHS) participants using the Illumina 450K BeadChip 1,070 FHS EPIC array. Blood data were collected all 2,115 RNA sequencing (RNA-seq). association between quantified for...
Background: Extracellular microRNAs (miRNAs) are a class of non-coding RNAs that resist degradation and remain stable in the extracellular milieu where they contribute to various physiological pathological processes by facilitating intercellular signaling. Previous studies have reported associations between miRNAs cardiovascular diseases (CVD); however, plasma miRNA signatures CVD its risk factors not been fully elucidated at population level. Methods: Plasma levels were measured 4,440...
Abstract DNA methylation commonly occurs at cytosine-phosphate-guanine sites (CpGs) that can serve as biomarkers for many diseases. We analyzed whole genome sequencing data to identify quantitative trait loci (mQTLs) in 4,126 Framingham Heart Study participants. Our mQTL mapping identified 94,362,817 cis -mQTLvariant-CpG pairs (for 210,156 unique autosomal CpGs) P <1e-7 and 33,572,145 trans -mQTL variant-CpG 213,606 <1e-14. Using variants 1,258 CpGs associated with seven cardiovascular...
Abstract To create a scientific resource of expression quantitative trail loci (eQTL), we conducted genome-wide association study (GWAS) using genotypes obtained from whole genome sequencing (WGS) DNA and gene levels RNA (RNA-seq) blood in 2622 participants Framingham Heart Study. We identified 6,778,286 cis -eQTL variant-gene transcript (eGene) pairs at p < 5x10 − 8 (2,855,111 unique variants 15,982 eGenes) 1,469,754 trans variant-eGene 1e-12 (526,056 7,233 eGenes). In addition, 442,379...