A5015131666- Computational Drug Discovery Methods
- Malaria Research and Control
- Plant biochemistry and biosynthesis
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Plant tissue culture and regeneration
- Analytical Chemistry and Chromatography
- Chemistry and Chemical Engineering
- Ammonia Synthesis and Nitrogen Reduction
- Advanced Control Systems Optimization
- Crystallization and Solubility Studies
- Microbial Metabolic Engineering and Bioproduction
- Process Optimization and Integration
- Spectroscopy and Chemometric Analyses
- Advanced Battery Technologies Research
- Hybrid Renewable Energy Systems
- Transgenic Plants and Applications
- thermodynamics and calorimetric analyses
University of Cambridge
2013-2018
University of Warwick
2013-2014
Artemisia annua hot water infusion (tea) has been used in vitro experiments against P. falciparum malaria parasites to test potency relative equivalent pure artemisinin. High performance liquid chromatography (HPLC) and mass spectrometric analyses were employed determine the metabolite profile of tea including concentrations artemisinin (47.5±0.8 mg L-1), dihydroartemisinic acid (70.0±0.3 arteannuin B (1.3±0.0 isovitexin (105.0±7.2 L-1) a range polyphenolic acids. The extract, purified...
Abstract In parts of Africa and Asia, self‐medication with a hot water infusion Artemisia annua ( tea) is common practice for number ailments including malaria cancer. our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine‐sensitive ‐resistant parasites. this study, in vitro tests the MCF7 cells high IC 50 values (>200 μ M ). The combination 3‐caffeoylquinic acid (3CA), two major components extract, was strongly antagonistic gave near total...
The expected world population growth by 2050 is likely to pose great challenges in the global food demand and, turn, fertilizer consumption. Food and Agricultural Organization of United Nations has forecasted that 46% this projected will be attributed Africa. This, raises further concerns about sustainability Africa’s contemporary production, considering also its high dependence on imports. Based these facts, a novel “green” route for synthesis fertilizers been considered context African...
Malaria is causing more than half of a million deaths and 214 clinical cases annually. Despite tremendous efforts for the control malaria, global morbidity mortality have not been significantly changed in last 50 years. Artemisinin, extracted from medicinal plant Artemisia sp. an effective anti-malarial drug. In 2015, elucidation effectiveness artemisinin as potent drug was acknowledged with Nobel prize. Owing to tight market low yield artemisinin, economical way increase its production...
Artemisia annua hot water infusion (tea) has been used in vitro experiments against P. falciparum malaria parasites to test potency relative equivalent pure artemisinin.High performance liquid chromatography (HPLC) and mass spectrometric analyses were employed determine the metabolite profile of tea including concentrations artemisinin (47.5±0.8 mg L -1 ), dihydroartemisinic acid (70.0±0.3 arteannuin B (1.3±0.0 isovitexin (105.0±7.2 ) a range polyphenolic acids.The extract, purified...
An improved liquid chromatography-tandem mass spectrometry (LC–MS/MS) protocol for rapid analysis of co-metabolites A. annua in raw extracts was developed and extensively characterized. The new method used to analyse metabolic profiles 13 varieties from an in-field growth programme Madagascar. Several multivariate data techniques consistently show the association artemisinin with dihydroartemisinic acid. These support hypothesis acid being late stage precursor its biosynthetic pathway.
Abstract An event‐driven approach based on dynamic optimization and nonlinear model predictive control (NMPC) is investigated together with inline Raman spectroscopy for process monitoring control. The benefits challenges in polymerization morphology are presented, an overview of the used mechanistic models details NMPC to achieve relevant objectives provided. Finally, implementation discussed, results from experiments lab pilot‐plant reactors presented.
Tetrafluoropropene (R1234yf) is the most likely replacement for tetrafluoroethane (R134a), a widely used refrigerant, propellant, and solvent, characterized by very high global warming potential. In this study, solvation properties of R1234yf were studied experimentally computationally solubility artemisinin, precursor to important biopharmaceutical API, extraction artemisinin from biomass. was shown be poorer solvent than R134a artemisinin. COSMO-RS calculations in suggest that decrease...