A5087710029- Tea Polyphenols and Effects
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Ginkgo biloba and Cashew Applications
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Inflammatory mediators and NSAID effects
- Asthma and respiratory diseases
- Pharmacological Effects and Toxicity Studies
- Phytochemicals and Antioxidant Activities
- Neuroendocrine regulation and behavior
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Chronic Kidney Disease and Diabetes
- Analytical Methods in Pharmaceuticals
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Epilepsy research and treatment
- Heavy Metals in Plants
- Infant Health and Development
- Analytical Chemistry and Chromatography
- Dialysis and Renal Disease Management
- Chemical Synthesis and Analysis
- Natural Antidiabetic Agents Studies
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
Fukushima Medical University
2014-2025
Fukushima Medical University Hospital
2021-2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2013-2015
University of Shizuoka
2006-2014
Shizuoka University
2006
Hamamatsu University School of Medicine
2006
Oita University
2006
This study aimed to evaluate the effects of green tea on pharmacokinetics and pharmacodynamics β-blocker nadolol. Ten healthy volunteers received a single oral dose 30 mg nadolol with or water after repeated consumption (700 ml/day) for 14 days. Catechin concentrations in plasma were determined. Green markedly decreased maximum concentration (Cmax) area under concentration–time curve (AUC0–48) by 85.3% 85.0%, respectively (P < 0.01), without altering renal clearance The systolic blood...
Green tea catechins inhibit the function of organic anion transporting polypeptides (OATPs) that mediate uptake a diverse group drugs and endogenous compounds into cells. The present study was aimed at investigating effect green its most abundant catechin epigallocatechin gallate (EGCG) on transport activity several drug transporters expressed in enterocytes, hepatocytes renal proximal tubular cells such as OATPs, cation (OCTs), multidrug toxin extrusion proteins (MATEs), P-glycoprotein...
Nadolol is a nonmetabolized β-adrenoceptor antagonist and substrate of OATP1A2, but not OATP2B1. However, other drug transporters involved in translocation nadolol have been characterized detail. We therefore investigated as potential the hepatic uptake OATP1B1, OATP1B3, OCT1 renal OCT2, MATE1, MATE2-K expressed HEK cells. Moreover, importance P-glycoprotein (P-gp) for transport was studied using double transfected MDCK-OCT1-P-gp transported by OATP1B1 OATP1B3. In contrast, significantly...
Abstract To evaluate effects of itraconazole, rifampicin and grapefruit juice on pharmacokinetics pharmacodynamics a hydrophilic non‐selective β‐adrenoceptor blocker nadolol, we conducted an open‐label, four‐way crossover study in 10 healthy male volunteers. A single oral dose 30 mg nadolol was administered with water (control), itraconazole (100 mg), or (300 mL), after 6‐day pretreatment (450 mg/day). Plasma concentrations urinary excretions were measured over 48 hours its dosing. Systolic...
ABSTRACT A rapid and quantitative analytical method for the simultaneous determination of green tea catechins using ultra‐performance liquid chromatography/electrospray ionization–mass spectrometry was developed. Total run time 3.5 min detection (−)‐epicatechin (EC), (−)‐epicatechin‐3‐ O ‐gallate (ECG), (−)‐epigallocatechin (EGC), (−)‐epigallocatechin‐3‐ (EGCG) myricetin as internal standard (IS) in rat plasma. The calibration curves were linear over range 10–5000 ng/mL all catechins. inter‐...
Abstract Canagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, has direct renoprotective effects beyond lowering blood levels. The inhibition of reabsorption via SGLT2 reduces the overload on proximal tubules, thereby suppressing generation reactive oxygen species (ROS) and preventing decline in renal function. To clarify pharmacological mechanism we investigated canagliflozin oxidative stress kidneys normal, non‐diabetic Sprague–Dawley rats. Screening using mass spectrometry...
Oxytocin (Oxt) is secreted to the peripheral body through pituitary gland and can induce insulin secretion under high glucose conditions. Insulin regulated by various factors including glucagon-like peptide (GLP)-1, from intestinal L-cells. GLP-1 also expressed within islets termed as "intra-islet GLP-1". The study aims elucidate impact of Oxt on in relation intra-islet GLP-1. We measured changes blood levels following administration wild-type (WT) receptor knockout (OxtR KO) mice....
Inflammation is one of major mechanisms contributing to the pathogenesis myocardial ischemia/reperfusion (I/R) injury. Pentraxin 3 (PTX3), produced in response inflammatory signals, acts as a humoral arm innate immunity. Here we investigated role PTX3 from bone marrow-derived cells I/R injury using PTX3-deficient (PTX3KO) mice.PTX3KO mice and wild-type littermate (WT) were lethally irradiated injected with marrow (BM) cells, generating four types (WT(WT-BM), WT(PTX3KO-BM), PTX3KO(WT-BM)...
Aims The aim of this study was to investigate the effects a single green tea (GT), administered concomitantly or 1 hour before nadolol intake on pharmacokinetics. Methods In randomized 3‐phase crossover study, 11 healthy volunteers received an oral administration with, after preingestion brewed GT, with water in volume 150 mL. Results Geometric mean ratio 90% confidence interval for AUC 0–48 0.371 (0.303–0.439) concomitant GT. addition, ingestion GT resulted significant reduction geometric...
In this study, we developed stabilized astaxanthin (AX) nanoparticles (sNP/AX) to improve the physicochemical properties, oral bioavailability, and hepatoprotection of AX. A flash nanoprecipitation technique was used with a multi-inlet vortex mixer prepare sNP/AX. Vitamins E (VE) C (VC) were as co-stabilizers poloxamer 407 stabilizer inhibit oxidative degradation AX during sNP/AX formation storage. VC in aqueous phase preparation, whereas VE markedly improved storage stability sNP/AX,...
Background:Sake lees (Sakekasu), a byproduct of sake production, has been recently attracting attention as functional food. Sakekasu is rich in nutrients and contains glycerophosphocholine (GPC) S-adenosylmethionine (SAM), which are well-known compounds. The content these compounds depends on variety factors, including fermentation conditions, especially the method length ripening. These differences reflected prominently color Sakekasu, becomes darker due to long ripening period high drying...
The high prevalence of obesity has become a pressing global public health problem and there exists strong association between increased BMI mortality at 25 kg/m 2 or higher. is higher among middle-aged adults than younger groups the combination aging exacerbate systemic inflammation. Increased inflammatory cytokines such as interleukin 6 tumor necrosis factor alpha (TNFα) are hallmarks obesity, promote secretion hepatic C-reactive protein (CRP) which further induces systematic neuropeptide...