A5033276205- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Boron Compounds in Chemistry
- Nonmelanoma Skin Cancer Studies
- Management of metastatic bone disease
- Advanced X-ray and CT Imaging
- Meningioma and schwannoma management
- Radiopharmaceutical Chemistry and Applications
- Breast Cancer Treatment Studies
- Head and Neck Cancer Studies
- Hematopoietic Stem Cell Transplantation
- Nuclear Physics and Applications
- MRI in cancer diagnosis
- interferon and immune responses
- Parasitic Diseases Research and Treatment
- Immune Response and Inflammation
- Occupational and environmental lung diseases
- Parasite Biology and Host Interactions
- Hepatocellular Carcinoma Treatment and Prognosis
- Machine Learning in Materials Science
University Hospital Bonn
2014-2025
University of Bonn
2005-2024
Government of the Republic of Korea
2020
Universitätsklinik für Strahlentherapie
2001-2019
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2001
Essen University Hospital
2001
University of Duisburg-Essen
2001
Residual tumor cells remain beyond the margins of every glioblastoma (GBM) resection. Their resistance to postsurgical therapy is considered a major driving force mortality, but their biology remains largely uncharacterized. In this study, residual were derived via experimental biopsy resection margin after standard neurosurgery for direct comparison with samples from routinely resected tissue. vitro analysis proliferation, invasion, stem cell qualities, GBM-typical antigens, genotypes, and...
Radiation dermatitis (RD) represents one of the most frequent side effects in radiotherapy (RT). Despite technical progress, mild and moderate RD still affects major subsets patients identification management with a high risk severe is essential. We sought to characterize surveillance nonpharmaceutical preventive German-speaking hospitals private centers.We conducted survey on among radiation oncologists inquiring for their evaluation factors, assessment methods, RD.A total 244 health...
Purpose: Radiation-induced skin injury represents one of the most common side effects in breast cancer patients receiving adjuvant whole-breast radiotherapy. Numerous systemic and topical treatments have been studied prevention management radiation-induced without providing sustainable treatment strategies. While superficial barrier-forming products such as dressings are standard care wound management, their utilization preventive approach radiotherapy has barely attracted attention.Methods:...
Radiation-induced skin injury represents the most frequent side effect in breast cancer patients undergoing whole-breast irradiation (WBI). Numerous clinical studies on systemic and topical treatments for radiation dermatitis have failed to provide sustainable treatment strategies. While protective products such as dressings are undoubtedly standard of care wound management, their utilization preventive radiotherapy has been somewhat neglected recent years. In this prospective, intra-patient...
Radiotherapy induces DNA damage, resulting in cell-cycle arrest and activation of cell-intrinsic death pathways. However, the radioresistance some tumour entities such as malignant melanoma limits its clinical application. The innate immune sensing receptor retinoic acid-inducible gene I (RIG-I) is ubiquitously expressed upon triggers an immunogenic form cell a variety types including melanoma. To date, potential RIG-I ligands to overcome cells has not been investigated. Here, we demonstrate...
Intraoperative radiation therapy (IORT) is an emerging alternative to adjuvant stereotactic external beam (EBRT) following resection of brain metastases (BM). Advantages IORT include instant prevention tumor regrowth, optimized dose-sparing adjacent healthy tissue and immediate completion BM treatment, allowing earlier admission subsequent systemic treatments. However, prospective outcome data are limited. We sought assess long-term in comparison EBRT.A total 35 consecutive patients,...
The role of radiotherapy in the context limited liver metastases is emerging rapidly with a variety available technical approaches. Here, we provide dosimetric comparison three different modalities for non-resected metastases. This multicentric study included 30 patients previously treated solitary Interstitial high dose-rate brachytherapy (HDR), stereotactic body radiation therapy (SBRT), and kilovoltage electronic (eBT) single dwelling point, as an this novel modality, were planned 25-Gy...
Intraoperative radiotherapy (IORT) of the operative cavity for surgically treated brain metastasis (BM) has gained increasing prominence with respect to improved local tumor control. However, IORT immediately performed at time surgery might be associated increased levels perioperative adverse events (PAEs). In present study, we safety metric profiling in patients who had undergone BM and without order comparatively analyze feasibility as an adjuvant radiation approach. Between November 2020...
Abstract Purpose Intraoperative radiotherapy (IORT) has become a viable treatment option for resectable brain metastases (BMs). As data on local control and radiation necrosis rates are maturing, we focus meaningful secondary endpoints such as time to next (TTNT), duration of postoperative corticosteroid treatment, in-hospital time. Methods Patients prospectively recruited within an IORT study registry between November 2020 June 2023 were compared with consecutive patients receiving adjuvant...
Abstract Background Activator Protein-2 (AP-2) transcription factors are critically involved in a variety of fundamental cellular processes such as proliferation, differentiation and apoptosis have also been implicated carcinogenesis. Expression the family members AP-2α AP-2γ is particularly well documented malignancies female breast. Despite increasing evaluation single AP-2 isoforms mammary tumors functional role concerted expression multiple breast cancer remains to be elucidated....
Total body irradiation (TBI) is often a component of the conditioning regimen prior to hematopoietic stem cell transplantation in patients with hematological malignancies. However, total marrow (TMI) could be an alternative method for reducing radiation therapy-associated toxicity, as it specifically targets skeleton and thus better protect organs at risk. Here, we compared dosimetric changes received by target volume risk between TBI TMI plans.Theoretical plans were calculated 35 various...
Abstract Background Intensity-modulated helical tomotherapy (HT) is a promising technique in preparation for bone marrow transplantation. Nevertheless, radiation-sensitive organs can be substantially compromised due to suboptimal delivery techniques of total body irradiation (TBI). To reduce the potential burden radiation toxicity at risk (OAR), high-quality coverage and homogeneity are essential. We investigated dosimetric data from kidney, lung thorax, liver, spleen relation peripheral...
Abstract To explore the image quality and radiation dose of dual source high-pitch cardiac computed tomography with tailored contrast injection protocols for pediatric congenital heart disease patients (CHD). In total, 27 infants CHD (median age 109 days [IQR 6–199]) were retrospectively analyzed regarding length product (DLP) effective (ED) after undergoing cardiothoracic CT imaging. Scan parameters adjusted on a source/detector (DSCT) to minimize while maintaining adequate quality. Image...
Canonical androgen receptor (AR) signaling regulates a network of DNA repair genes in prostate cancer (PCA). Experimental and clinical evidence indicates that deprivation not only suppresses activity but is often synthetically lethal combination with PARP inhibition. The present study aimed to elucidate the impact AR splice variants (AR-Vs), occurring advanced or late-stage PCA, on machinery.
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human malignancies and carries an exceptionally poor prognosis. It mostly driven by multiple oncogenic alterations, with highest mutation frequency being observed in KRAS gene, which a key driver tumorogenesis malignant progression PDAC. However, remained undruggable for decades until emergence G12C specific inhibitors. Despite this development, therapeutic approach to target directly not routinely used PDAC patients, reasons...
We observed visual sensations (VSs) in patients undergoing intensity modulated radiotherapy (IMRT) of the brain without beam passing through ocular structures. analyzed this phenomenon especially with regards to reproducibility, and origin.Analyzed were ten consecutive (aged 41-71 years) glioblastoma multiforme who received pulsed IMRT (total dose 60Gy) helical tomotherapy (TT). A megavolt-CT (MVCT) was performed daily before treatment. VSs reported recorded using a triggered event recorder....
Purpose To simulate and analyze the dosimetric differences of intraoperative radiotherapy (IORT) or pre-operative single-fraction stereotactic radiosurgery (SRS) in addition to post-operative external beam (EBRT) Glioblastoma (GB). Methods Imaging series previously treated patients with adjuvant radiochemotherapy were analyzed. For SRS target definition, MRIs co-registered planning CT scans a T1-weighted gross volume (GTV) plus 2-mm (PTV) created. IORT, modified (m)GTV was expanded from...
Objective: In order to test for mechanisms of whole brain radio therapy side effects and possible neuroprotective measures, a rodent model is desirable. many models, high single dose 8–20 Gray (Gy) irradiation used. These experimental radiation protocols do not closely reflect the clinical situation, where cumulative dosage applied in smaller fractions. We describe an efficient method perform repetitive, fractionated rat brain.Methods: Fifteen-week-old rats were irradiated with 5 or 10 Gy on...