A5024024391- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Radiopharmaceutical Chemistry and Applications
- Testicular diseases and treatments
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Hormonal and reproductive studies
- Renal and related cancers
- Cancer, Lipids, and Metabolism
- Bone health and treatments
- Cancer Genomics and Diagnostics
- Multiple and Secondary Primary Cancers
- Sarcoma Diagnosis and Treatment
- Ureteral procedures and complications
- Genital Health and Disease
- Medical and Health Sciences Research
- Genetic factors in colorectal cancer
- Pediatric Urology and Nephrology Studies
- Adrenal and Paraganglionic Tumors
- Sexual Differentiation and Disorders
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
Johanniter-Krankenhaus Bonn
2021-2025
Saarland University
2014-2024
Arbeitsgemeinschaft Urologische Onkologie
2018-2024
German Cancer Society
2022-2024
Malteser-Krankenhaus
2018-2021
Hôpital Femme Mère Enfant
2020
Universitätsklinikum des Saarlandes
2008-2017
Berlin Heart (Germany)
2017
University Medical Center Hamburg-Eppendorf
2016
Universität Hamburg
2016
Background MicroRNA expression is altered in cancer cells, and microRNAs could serve as diagnostic/prognostic biomarker for patients. Our study was designed to analyze circulating serum patients with renal cell carcinoma (RCC). Methodology/Principal Findings We first explored microRNA profiles tissue using TaqMan Low Density Arrays each six malignant benign samples: Although 109 were at higher levels patients' serum, we identified only 36 up-regulation RCC of Seven candidate selected...
What's known on the subject? and What does study add? There is evidence from large abdominal surgeries some open cystectomy series that multifactorial fast‐track regimens shorten postoperative convalescence without any effect morbidity mortality. Such a regimen of particular interest in combination with minimally invasive techniques, as early patient recovery demands for more rapid nutrition mobilisation schemes. The present study, single institution, reports design, application results...
Background Does the dogma of nephron sparing surgery (NSS) still stand for large renal masses? Available studies dealing with that issue are considerably biased often mixing imperative elective indications NSS and also including less malignant variants or even benign tumors. Here, we analyzed oncological long-term outcomes patients undergoing radical tumor nephrectomy (RN) non-endophytic, (≥7cm) clear cell carcinoma (ccRCC). Methods Prospectively acquired, clinical databases from two...
Muscle-invasive bladder cancer (MIBC) represents a highly aggressive tumor type compared to non-muscle-invasive tumors. MIBC is characterized by specific molecular alterations, which may also modulate extracellular tumorigenic effects. Tumor-associated exosomes, especially exosomal miRNAs, are important regulators in the interaction between cells and microenvironment affecting tumor-promoting processes target cells. It analyze whether their patterns reflect characteristics of MIBC. The aim...
Liposomal encapsulation of doxorubicin has been shown to reduce nonspecific delivery this agent normal tissue and increase specific malignant cells. On the basis doxorubicin's demonstrated clinical efficacy against hormone-refractory prostate carcinoma (HRPCA), authors conducted a prospective, randomized Phase II trial evaluate feasibility, toxicity, therapeutic associated with pegylated form agent.Forty-eight patients symptomatic HRPCA were receive liposomal at either 25 mg/m2 every 2 weeks...
<b><i>Purpose:</i></b> To assess clinical outcomes and reimbursement costs of open robotic-assisted radical prostatectomies in Germany. <b><i>Methods:</i></b> Perioperative data 499 (2003-2006) 932 (2008-2010) as well longitudinal an anonymized health insurance research database from Germany containing patients who underwent or prostatectomy were retrospectively analysed a single-centre study. <b><i>Results:</i></b>...
Objectives To compare robot‐assisted laparoscopic adrenalectomy ( RALA ) and open OA with regard to intra‐operative complications, peri‐operative outcome cost effectiveness. Subjects Methods Functional statistical data from patients who underwent or between 2001 2015 were prospectively recorded including intra‐ postoperative outcomes. Data on per‐day costs current census reports (€540/day €1 145/day for normal intermediate care [ IMC ]) also used evaluate treatment costs. Additional assumed...
Abstract Purpose This study seeks to contribute real-world data on the prevalence of BRCA1/2 and HRR gene mutations in prostate cancer. Methods We compiled sequencing 197 cases primary metastatic cancer, which mutation analysis was performed upon clinical request within last 5 years. All were analyzed using a targeted NGS BRCAness multigene panel, including 8 genes (ATM, BRCA1, BRCA2, CDK12, CHEK2, FANCA, HDAC2, PALB2). Results Our findings reveal potentially targetable based FDA criteria...
Recent real-world studies compared effectiveness and safety of enzalutamide (ENZA) abiraterone acetate (AA) for metastatic castration-resistant prostate cancer (mCRPC). The growing evidence needs further substantiation with long-term data. This study, the first to use German data, investigated cardiovascular (CV) event risk overall survival (OS) in patients initiating ENZA or AA. AA (2012) (2014) are widely used mCRPC Germany. retrospective study data chemotherapy-naïve on (2012–2020) from...
<b><i>Objective:</i></b> The efficacy of second-line treatment after failure platinum-based chemotherapy in patients with advanced urothelial cancer is limited. Based on encouraging preclinical and clinical phase I data, we evaluated the safety combination paclitaxel everolimus these patients. <b><i>Methods:</i></b> In this trial, having failed to respond prior were treated (175 mg/m<sup>2</sup> i.v., 3-weekly) mTOR-inhibitor (10 mg...
Kidney autotransplantation (KAT) is the ultimate approach for nephron-sparing surgery. It a rarely used method in renal tumor surgery today as minimal invasive and open techniques improve constantly. In this publication, complication rate long-term functional oncological outcome at single center are analyzed.A prospectively constructed database of patients with tumors who underwent was retrospectively analyzed to identify KAT describe surgical outcomes obtain follow-up. Data collection...
Abstract Background Although the benefit of androgen deprivation therapy (ADT) continuation in metastatic castration-resistant prostate cancer (mCRPC) remains controversial, clinical evidence is lacking. Recent results indicated that treatment with abiraterone acetate (AA) plus prednisone (P) further suppresses serum testosterone levels over ADT alone, suggesting mCRPC may not be necessary. Methods In this exploratory phase 2 study, patients were randomized a 1:1 ratio to receive either...