A5102009998- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Testicular diseases and treatments
- Epigenetics and DNA Methylation
- Antimicrobial Peptides and Activities
- Cancer Immunotherapy and Biomarkers
- Urologic and reproductive health conditions
- Renal and related cancers
- Infectious Disease Case Reports and Treatments
- Wnt/β-catenin signaling in development and cancer
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Health and Medical Studies
- Ovarian cancer diagnosis and treatment
- Radiopharmaceutical Chemistry and Applications
- Ferroptosis and cancer prognosis
- Hormonal and reproductive studies
- Cholesterol and Lipid Metabolism
- Polyamine Metabolism and Applications
- Microtubule and mitosis dynamics
- Childhood Cancer Survivors' Quality of Life
Saarland University
2004-2024
Centrum für Integrierte Onkologie
2024
University Hospital Cologne
2024
Schmerzklinik Kiel
2010-2023
Ferring Pharmaceuticals (United Kingdom)
2023
Praxis für Humangenetik
2018-2019
Arbeitsgemeinschaft Urologische Onkologie
2003-2018
University of Göttingen
2018
University of Fribourg
2016
Klinikum rechts der Isar
2010-2016
Retroperitoneal lymph node dissection (RPLND) and adjuvant chemotherapy are two treatment options for patients with clinical stage I nonseminomatous germ cell tumors of the testis (NSGCT). Aim this trial was to prove advantage one cycle bleomycin, etoposide, cisplatin (BEP) compared RPLND in terms recurrence.Between 1996 2005, 382 were randomly assigned receive either (n = 191) or course BEP after orchidectomy. The primary study end point rate recurrence. powered detect a 7% reduction (from...
This study evaluated the cytotoxic and antiproliferative efficacy of two well-characterized members Cecropin-family antimicrobial peptides against bladder tumor cells benign fibroblasts. The potential Cecropins A B was quantified by colorimetric WST-1-, BrdU- LDH-assays in four cancer cell lines as well murine human fibroblast lines. IC50 values were assessed logarithmic extrapolation, representing concentration at which viability reduced 50%. Scanning electron microscopy (SEM) performed to...
Radical cystectomy as standard treatment of muscle-invasive urothelial carcinoma the urinary bladder cures less than 50% patients with locally advanced cancer. We compared two adjuvant combination chemotherapies in stage pT3a-4a and/or pathologic node-positive transitional-cell after radical cystectomy.A total 327 were randomly assigned to either systemic chemotherapy three cycles cisplatin 70 mg/qm(2) on day 1 and methotrexate 40 days 8 15 a 21-day cycle (CM) or 30 1, 15, 22, vinblastine 3...
To report the long-term follow-up of patients with locally advanced bladder cancer treated either adjuvant combined chemotherapy methotrexate, vinblastine, doxorubicin/epirubicin, and cisplatin (MVAC/MVEC) or no additional treatment after radical cystectomy, to examine various survival endpoints factors associated survival.Between May 1987 December 1990, 49 undergoing cystectomy for were randomized observation only systemic three cycles MVAC/MVEC (methotrexate 30 mg/m(2) on day 1, 15 22;...
Targeted therapies have demonstrated clinical benefit with limited impact on long-term disease specific survival in the treatment of renal cell cancer (RCC). New opportunities for tumors that are resistant or relapsed, needed. Increased anaerobic glucose fermentation to lactate (aerobic glycolysis), leading oxygen- and mitochondria-independent ATP generation is a hallmark aggressive growth. This metabolic shift results increased production via cycling through pentose phosphate pathway (PPP),...
Abstract The WHO 2004 classification defines new histological and molecular variants of urothelial carcinoma. However, there are limited data available on the clinicopathological characteristics or prognosis these variants. We present histopathological, clinical 32 plasmacytoid carcinomas bladder (PUC) showing that PUC is a high‐grade tumor with features aggressive carcinoma, usually diagnosed in advanced pathological stage (64% pT3, 23% pT4) metastases 60% patients. Average survival our...
Since the definition of different histologic subtypes urothelial carcinomas by World Health Organization (WHO) 2004 classification, description molecular features and clinical behavior these variants has gained more attention. We reviewed 205 tumor samples patients with locally advanced bladder cancer mainly treated within randomized AUO-AB05/95 trial radical cystectomy adjuvant cisplatin-based chemotherapy for subtypes. 178 UC, 18 plasmacytoid (PUC) 9 micropapillary (MPC) were identified....
What's known on the subject? and What does study add? There is evidence from large abdominal surgeries some open cystectomy series that multifactorial fast‐track regimens shorten postoperative convalescence without any effect morbidity mortality. Such a regimen of particular interest in combination with minimally invasive techniques, as early patient recovery demands for more rapid nutrition mobilisation schemes. The present study, single institution, reports design, application results...
: Recent studies of rare cases pT3a renal cell carcinoma extending directly into the adrenal gland showed worse survival than in other and recategorization as stage pT4 was suggested. We assessed prognostic validity a diagnosis based on perirenal fat infiltration.: The records 1,794 patients with who underwent surgical resection between 1975 2000 at our institution were analyzed retrospectively. Focusing tumors, defined by infiltration, numerous clinical histopathological parameters...
Constitutive expression and localization of antimicrobial human β-defensin-1 (HBD-1) in kidneys as a potential mechanism defense has been previously reported. Inducible β-defensin-2 (HBD-2) described various epithelial organs but not for the urogenital tract. We investigated gene- protein HBD-1 HBD-2 by reverse transcriptase-polymerase chain reaction, immunohistochemistry 15 normal kidney samples renal tissues with chronic bacterial infection. Additionally, cell culture experiments were...
Botulinum toxin type A (BoNT/A) proved very effective in therapy for hyperactive detrusor or sphincter dysfunction of neurogenic and non-neurogenic origin. However, may fail. In a search possible reasons, we investigated the presence BoNT/A antibodies (BoNT/A-AB) patients who were treated more than once correlated with clinical findings.In 25 (aged 11-75 years; average, 48.3 years) had experienced at least one previous and/or injection, BoNT/A-AB was detected mouse diaphragm assay before...
Abstract Transitional cell carcinoma of the urinary bladder remains life threatening due to high occurrence metastases. Emerging evidence suggests that chemokines and their receptors play a critical role in tumor In our study, we performed systematic analysis mRNA protein expression levels all 18 chemokine normal urothelium cancer. CXCR4 was only receptor whose level upregulated cancer lines as well invasive locally advanced tissue samples (pT2–pT4). contrast, superficial tumors (pTa pT1)...
4503 Background: The extent of pelvic lymph node dissection (PLND) in bladder cancer patients (pts.) undergoing radical cystectomy may affect survival according to retrospective studies. German Urologic Oncology Group (AUO) reports mature data the first prospective, randomized clinical trial evaluate impact a limited versus an extended PLND. Methods: Pts. with high-grade T1 or invasive urothelial (cT2-T4a) from 16 centers were 1:1 receive PLND at time cystectomy. Limited included 6 fields...