A5011222908- Signaling Pathways in Disease
- Cardiac Fibrosis and Remodeling
- Galectins and Cancer Biology
- Genetics, Aging, and Longevity in Model Organisms
- Blood Coagulation and Thrombosis Mechanisms
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Connective tissue disorders research
- Congenital heart defects research
- Cardiomyopathy and Myosin Studies
- Macrophage Migration Inhibitory Factor
Centro de Investigación Biomédica en Red
2022-2025
Spanish National Centre for Cardiovascular Research
2016-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2022-2025
Angiotensin-II (Ang-II) drives pathological vascular wall remodeling in hypertension and abdominal aortic aneurysm (AAA) through mechanisms that are not completely understood. Previous studies showed the phosphatase activity of calcineurin (Cn) mediates Ang-II-induced AAA, but cell type involved action Cn AAA formation remained unknown. Here, by employing newly created smooth muscle (SMC)-specific endothelial (EC)-specific Cn-deficient mice (SM-Cn −/− EC-Cn mice), we show expressed SMCs,...
Aortic intramural hematoma (IMH) can evolve toward reabsorption, dissection or aneurysm. Hypertension is the most common predisposing factor in IMH and aneurysm patients, hypertensive mediator angiotensin-II induces both mice. We have previously shown that constitutive deletion of Rcan1 isoforms prevents Angiotensin II-induced Here we generate mice conditionally lacking each isoform all vascular smooth muscle cells, endothelial ubiquitously, to determine contribution development cells....
The sarcomere regulates striated muscle contraction. This structure is composed of several myofibril proteins, isoforms which are encoded by genes specific to either the heart or skeletal muscle. chromatin remodeler complex Chd4/NuRD transcriptional expression these sarcomeric programs repressing in heart. Aberrant induced loss Chd4 leads sudden death due defects cardiomyocyte contraction that progress arrhythmia and fibrosis. Identifying transcription factors (TFs) recruit repress...
STRUCTURED ABSTRACT Objective: Angiotensin-II (Ang-II) drives pathological vascular wall remodeling in hypertension and abdominal aortic aneurysm (AAA). Previous studies showed that the phosphatase activity of calcineurin (Cn) mediates Ang-II-induced AAA, but cell type involved action Cn AAA formation remained unknown. Methods: Smooth muscle (SMC)-specific endothelial (EC)-specific Cn-deficient mice ( SM-Cn -/- EC-Cn mice, respectively) were created assessed for vs controls. Osmotic...