A5015743312- Signaling Pathways in Disease
- Cell Adhesion Molecules Research
- Bone Metabolism and Diseases
- Systemic Sclerosis and Related Diseases
- Protease and Inhibitor Mechanisms
- Galectins and Cancer Biology
- Protein Kinase Regulation and GTPase Signaling
- Congenital heart defects research
- Immune Cell Function and Interaction
- Pharmacological Effects and Toxicity Studies
- Ocular Oncology and Treatments
- Biological Stains and Phytochemicals
- Dermatological and Skeletal Disorders
- Pharmaceutical studies and practices
- Macrophage Migration Inhibitory Factor
- Neuropeptides and Animal Physiology
- Systemic Lupus Erythematosus Research
- Ubiquitin and proteasome pathways
- Mass Spectrometry Techniques and Applications
- Pregnancy and Medication Impact
- Antifungal resistance and susceptibility
- Connective tissue disorders research
- MicroRNA in disease regulation
- Iron Metabolism and Disorders
- Estrogen and related hormone effects
Harvard University
2016-2020
GlaxoSmithKline (United Kingdom)
2020
Brigham and Women's Hospital
2015-2020
Spanish National Centre for Cardiovascular Research
2011-2019
Evolution is replete with reuse of genes in different contexts, leading to multifunctional roles signaling factors during development. Here, we explore osteoclast regulation skeletal development through analysis colony-stimulating factor 1 receptor (csf1r) function the zebrafish. A primary role Csf1r regulate proliferation, differentiation and myelomonocytic cells, including osteoclasts. We demonstrate retention two functional paralogues csf1r Mutant indicates that have shared, non-redundant...
Research Article15 October 2013Open Access A major role for RCAN1 in atherosclerosis progression Nerea Méndez-Barbero Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain Search more papers by this author Vanesa Esteban Silvia Villahoz Amelia Escolano Katia Urso Arantzazu Alfranca Human Genetics Department, Institute Rare Diseases Research, Carlos III Health Institute, Cristina Rodríguez Investigación Cardiovascular (CSIC-ICCC),...
Increase in intracellular calcium ([Ca 2+ ] i ) is a key mediator of astrocyte signaling, important for activation the calcineurin (CN)/nuclear factor activated T cells (NFAT) pathway, central inflammatory events. We analyzed expression matrix metalloproteinase 3 ( Mmp3 response to increases [Ca and role CN/NFAT pathway this regulation. Astrocyte was induced by overexpression constitutively active form NFATc3, whereas other MMPs tissue inhibitor metalloproteinases (TIMP) were unaffected....
Abstract Calcium/Calcineurin/Nuclear Factor of Activated T cells (Ca/CN/NFAT) signalling pathway is the main calcium (Ca 2+ ) dependent involved in homeostasis brain tissue. Here, we study presence NFATc members human glioma by using U251 and a collection primary glioblastoma (hGB) cell lines. We show that NFATc3 member predominant member. Furthermore, constitutive active mutant shRNA lentiviral vectors to achieve specific silencing this member, describe cytokines molecules regulated which...
What is already known on this subject ► TRIM21/Ro52 a major autoantibody target in pSS and regulates downstream signalling of type I IFNs.► Apoptosis-associated surface expression TRIM21 non-immune cells associated with enhanced binding anti-Ro52 autoantibodies. study adds► Enhanced IFNproducing immune from patients an IFN signature B cell hyperactivity.► expressed the nonapoptotic antigen-presenting its by IFN-β exposure. How might impact clinical practice► Elucidating relationship between...
Although physical therapy can help preserve mobility in patients with systemic sclerosis (SSc), stretching has not been used systematically as a treatment to prevent or reverse the disease process. We previously showed rodent models that promotes resolution of connective tissue inflammation and reduces new collagen formation after injury. Here, we tested hypothesis would impact scleroderma development using mouse sclerodermatous graft-versus-host (sclGvHD) model.The model consists adoptive...
Most E2F-binding sites repress transcription through the recruitment of Retinoblastoma (RB) family members until end G1 cell-cycle phase. Although MYB promoter contains an site, its is activated shortly after exit from quiescence, before RB inactivation, by unknown mechanisms. We had previously uncovered a nuclear factor distinct E2F, Myb-sp, whose DNA-binding site overlapped E2F element and hypothesized that this might overcome transcriptional repression E2F-RB members. have purified Myb-sp...
Aortic intramural hematoma (IMH) can evolve toward reabsorption, dissection or aneurysm. Hypertension is the most common predisposing factor in IMH and aneurysm patients, hypertensive mediator angiotensin-II induces both mice. We have previously shown that constitutive deletion of Rcan1 isoforms prevents Angiotensin II-induced Here we generate mice conditionally lacking each isoform all vascular smooth muscle cells, endothelial ubiquitously, to determine contribution development cells....
Systemic sclerosis (SSc) is a potentially fatal autoimmune disorder with limited therapeutic options. Sclerodermatous graft versus host disease (sclGvHD), induced by transfer of B10.D2 splenocytes into BALB/c Rag2-/- mice, models an inflammatory subset SSc characterized prominent IL13-induced gene expression signature in the skin. Host mice deficient IL4RA, subunit type II IL4/IL13 receptor, are protected from sclGvHD. While IL4RA has well-established role Th2 differentiation and alternative...
Oral iron supplementation constitutes the first line treatment for deficiency anemia (IDA), with daily doses between 80 mg and 200 of elemental iron. Ferrous salts, such as ferrous sulphate (FeSO4), while efficacious, frequently give rise to gastrointestinal side effects. In present paper we attempted directly compare efficacy an alternative FeSO4 formulation, which presents a better tolerability profile, protein succinylate (Ferplex®). diet-induced model, rats were treated by oral gavage...
Anion exchanger 2 (Ae2; gene symbol, Slc4a2) is a plasma membrane Cl-/HCO3- expressed in the gastrointestinal tract, kidney and bone. We have previously shown that Ae2 required for function of osteoclasts, bone resorbing cells macrophage lineage, to maintain homeostatic cytoplasmic pH electroneutrality during acid secretion. Macrophages require endosomal acidification pathogen killing process known as phagocytosis. Chloride thought be principal ion responsible maintaining organelle...
Nausea and vomiting is a very prevalent condition during pregnancy. Combination of doxylamine pyridoxine placed as first-line pharmacological option for its treatment in most clinical guidelines. Among different release forms available, Cariban
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Abstract Scleroderma is an autoimmune disease characterized by inflammation and fibrosis in skin internal organs. We utilized a murine Graft Versus Host Disease (GVHD) model of (SclGVHD), which lymphocytes are transferred from B10.D2 mice (graft) into MHC-matched, lymphocyte deficient Balb/c Rag2-/- (host, sclGVHD mice). Over the course 6 weeks, develop fibrosis. Previously, we identified IL13 pathway activation scleroderma patients. Accordingly, host lacking IL4RA, functional subunit for...